Detalhe da pesquisa
1.
Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice.
J Cell Sci
; 136(13)2023 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37282854
2.
DNA demethylation fine-tunes IL-2 production during thymic regulatory T cell differentiation.
EMBO Rep
; 24(5): e55543, 2023 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36880575
3.
Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype.
J Biol Chem
; 296: 100733, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33957124
4.
Targeting the endo-lysosomal autophagy pathway to treat inflammatory bowel diseases.
J Autoimmun
; 128: 102814, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35298976
5.
ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).
J Biol Chem
; 295(13): 4350-4358, 2020 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32060096
6.
Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains.
FASEB J
; 34(4): 4956-4969, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32103528
7.
A Disintegrin and Metalloproteases (ADAMs): Activation, Regulation and Mechanisms of Catalysis.
Int J Mol Sci
; 22(16)2021 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34445468
8.
Members of the Fibroblast Growth Factor Receptor Superfamily Are Proteolytically Cleaved by Two Differently Activated Metalloproteases.
Int J Mol Sci
; 22(6)2021 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33804608
9.
Analysis of the Conditions That Affect the Selective Processing of Endogenous Notch1 by ADAM10 and ADAM17.
Int J Mol Sci
; 22(4)2021 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33673337
10.
Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α-converting enzyme.
J Biol Chem
; 293(8): 2725-2734, 2018 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29317500
11.
Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.
J Cell Sci
; 130(5): 868-878, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28104813
12.
The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands.
J Cell Physiol
; 233(3): 2247-2256, 2018 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-28703301
13.
Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays.
Biochem J
; 474(9): 1467-1479, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28264989
14.
iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.
Proc Natl Acad Sci U S A
; 112(19): 6080-5, 2015 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25918388
15.
iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice.
Eur J Immunol
; 46(12): 2737-2748, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27601030
16.
The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site.
J Biol Chem
; 290(19): 12135-46, 2015 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25795784
17.
The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding.
J Biol Chem
; 290(12): 7416-25, 2015 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25605720
18.
iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding.
Proc Natl Acad Sci U S A
; 110(28): 11433-8, 2013 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23801765
19.
LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2-GSDMD Axis-Mediated Gut Inflammation.
Cells
; 13(7)2024 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38607004
20.
Functional Distinctions of Endometrial Cancer-Associated Mutations in the Fibroblast Growth Factor Receptor 2 Gene.
Cells
; 12(18)2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37759450