Detalhe da pesquisa
1.
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer.
Gut
; 72(2): 360-371, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35623884
2.
Cardiac Overexpression of PDE4B Blunts ß-Adrenergic Response and Maladaptive Remodeling in Heart Failure.
Circulation
; 142(2): 161-174, 2020 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32264695
3.
Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes.
Nat Chem Biol
; 14(8): 801-810, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29915378
4.
Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth.
Circulation
; 138(7): 696-711, 2018 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29348263
5.
Response by Vandecasteele et al to Letter Regarding Article, "Cardiac Overexpression of PDE4B Blunts ß-Adrenergic Response and Maladaptive Remodeling in Heart Failure".
Circulation
; 143(4): e26-e27, 2021 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33493025
6.
Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation.
J Am Soc Nephrol
; 27(4): 1135-44, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26271513
7.
Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF).
Curr Heart Fail Rep
; 14(3): 187-196, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28451983
8.
The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors.
Molecules
; 20(9): 17275-87, 2015 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26393561
9.
Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation.
Cardiovasc Res
; 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38776406
10.
PI3K Signaling in Mechanisms and Treatments of Pulmonary Fibrosis Following Sepsis and Acute Lung Injury.
Biomedicines
; 10(4)2022 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35453505
11.
Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer.
Adv Sci (Weinh)
; 9(9): e2103249, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35098698
12.
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Science
; 374(6573): eabk0410, 2021 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34882480
13.
The PI3K/Akt/mTOR pathway in polycystic kidney disease: A complex interaction with polycystins and primary cilium.
Cell Signal
; 66: 109468, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31715259
14.
A Novel Multiplex qRT-PCR Assay to Detect SARS-CoV-2 Infection: High Sensitivity and Increased Testing Capacity.
Microorganisms
; 8(7)2020 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32708870
15.
Class II PI3K Functions in Cell Biology and Disease.
Trends Cell Biol
; 29(4): 339-359, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30691999
16.
Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking.
Biomolecules
; 9(3)2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30884740
17.
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.
Nat Commun
; 9(1): 3772, 2018 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30217979
18.
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.
ChemMedChem
; 12(18): 1542-1554, 2017 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28857471
19.
Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function.
Cancer Cell
; 32(4): 444-459.e7, 2017 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29017056
20.
PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.
Dev Cell
; 28(6): 647-58, 2014 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-24697898