Preterm labour detection by use of a biophysical marker: the uterine electrical activity.

BACKGROUND: The electrical activity of the uterine muscle is representative of uterine contractility. Its characterization may be used to detect a potential risk of preterm delivery in women, even at an early gestational stage. METHODS: We have investigated the effect of the recording electrode position on the spectral content of the signal by using a mathematical model of the women's abdomen. We have then compared the simulated results to actual recordings. On signals with noise reduced with a dedicated algorithm, we have characterized the main frequency components of the signal spectrum in order to compute parameters indicative of different situations: preterm contractions resulting nonetheless in term delivery (i.e. normal contractions) and preterm contractions leading to preterm delivery (i.e. high-risk contractions). A diagnosis system permitted us to discriminate between these different categories of contractions. As the position of the placenta seems to affect the frequency content of electrical activity, we have also investigated in monkeys, with internal electrodes attached on the uterus, the effect of the placenta on the spectral content of the electrical signals. RESULTS: In women, the best electrode position was the median vertical axis of the abdomen. The discrimination between high risk and normal contractions showed that it was possible to detect a risk of preterm labour as early as at the 27th week of pregnancy (Misclassification Rate range: 11-19.5%). Placental influence on electrical signals was evidenced in animal recordings, with higher energy content in high frequency bands, for signals recorded away from the placenta when compared to signals recorded above the placental insertion. However, we noticed, from pregnancy to labour, a similar evolution of the frequency content of the signal towards high frequencies, whatever the relative position of electrodes and placenta. CONCLUSION: On human recordings, this study has proved that it is possible to detect, by non-invasive abdominal recordings, a risk of preterm birth as early as the 27th week of pregnancy. On animal signals, we have evidenced that the placenta exerts a local influence on the characteristics of the electrical activity of the uterus. However, these differences have a small influence on premature delivery risk diagnosis when using proper diagnosis tools.

Speed-accuracy tradeoff during performance of a tracking task without visual feedback.

To help people with visual impairment, especially people with severely impaired vision, access graphic information on a computer screen, we have carried out fundamental research on the effect of increasing the number of detection fields. In general, application of the parallelism concept enables information to be accessed more precisely and easily when the number of sensors is high. We have developed a "Braille Box" by modifying Braille cells to form a tactile stimulator array which is compatible with the fingertip. Each pin can be controlled independently so that we can change the size and type of array in order to study the tactile perception of both simple and complex graphical forms. Our results show that by applying the parallelism concept to the detection field, people with visual impairment can increase the speed of exploration of geometric forms without decreasing the level of accuracy: thus, avoiding a speed-accuracy tradeoff. Further experiments need to be done with this Braille Box in order to improve the device and help people with visual impairment access graphic information.