Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 58
Filtrar
1.
J Arthroplasty ; 39(9S2): S122-S128, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38685337

RESUMO

BACKGROUND: Periprosthetic joint infection (PJI) is a devastating complication following both total hip (THA) and knee (TKA) arthroplasty. Extended oral antibiotic (EOA) prophylaxis has been reported to reduce PJI following TJA in high-risk patients. The purpose of this study was to determine if EOA reduces PJI in all-comers and high-risk THA and TKA populations. METHODS: This is a retrospective cohort study, including 4,576 patients undergoing primary THA or TKA at a single institution from 2018 to 2022. Beginning in 2020, EOA prophylaxis was administered for 10 days following THA or TKA at our institution. Patients were separated into 2 cohorts (1,769 EOA, 2,807 no EOA) based on whether they received postoperative EOA. The 90-day and 1-year outcomes, with a focus on PJI, were then compared between groups. A subgroup analysis of high-risk patients was also performed. RESULTS: There was no difference in 90-day PJI rates between cohorts (EOA 1 versus no EOA 0.8%; P = .6). The difference in the rate of PJI remained insignificant at 1 year (EOA 1 versus no EOA 1%; P = .9). Similarly, our subgroup analysis of high-risk patients demonstrated no difference in postoperative PJI between EOA (n = 254) and no EOA (n = 396) (0.8 versus 2.3%, respectively; P = .2). Reassuringly, we also found no differences in the incidence of Clostridium difficile infection (EOA 0.1 versus no EOA 0.1%; P > .9) or in antibiotic resistance among those who developed PJI within 90 days (EOA 59 versus no EOA 83%; P = .2). CONCLUSIONS: With the numbers available for analysis, EOA prophylaxis was not associated with PJI risk reduction following primary TJA when universally deployed. Furthermore, among high-risk patients, there was no statistically significant difference. While we did not identify increased antibiotic resistance or Clostridium difficile infection, we cannot recommend wide-spread adoption of EOA prophylaxis, and clarification regarding the role of EOA, even in high-risk patients, is needed.


Assuntos
Antibacterianos , Antibioticoprofilaxia , Artroplastia de Quadril , Artroplastia do Joelho , Infecções Relacionadas à Prótese , Humanos , Antibioticoprofilaxia/métodos , Artroplastia do Joelho/efeitos adversos , Estudos Retrospectivos , Masculino , Feminino , Artroplastia de Quadril/efeitos adversos , Infecções Relacionadas à Prótese/prevenção & controle , Infecções Relacionadas à Prótese/etiologia , Idoso , Pessoa de Meia-Idade , Antibacterianos/administração & dosagem , Administração Oral
2.
Arthroscopy ; 2023 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-37865130

RESUMO

PURPOSE: The purpose of this study was to determine whether preoperative patient-reported outcomes (PROs) predict postoperative PROs and satisfaction following rotator cuff repair. METHODS: We retrospectively identified patients who underwent a primary rotator cuff repair at a single institution. A receiver operating characteristics (ROC) analysis was used to reach a preoperative American Shoulder and Elbow Surgeons (ASES) score threshold predictive of postoperative ASES and satisfaction scores. We evaluated patients above and below the ROC threshold by comparing their final ASES scores, ASES change (Δ) from baseline, percent maximum outcome improvement (%MOI), and achievement of minimum clinically important differences (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS). Fischer exact tests were used to analyze categorical data, while continuous data were analyzed using t-test. RESULTS: A total of 348 patients who underwent rotator cuff repair were included in this study. The preop ASES value predictive of achieving SCB was 63 (area under the curve [AUC], 0.75; 95% confidence interval: 58-67; P < .001). Patients with preoperative ASES less than 63 were significantly more likely to achieve MCID (odds ratio [OR]: 4.7, P < .001) and SCB (OR:6.1, P < .001) and had significantly higher %MOI (63% vs 41%; P = 0.003) and Δ ASES scores (36 vs 12; P < .001). However, patients with preop ASES scores above 63 had significantly higher final ASES scores (86 vs 79; P = .003), were more likely to achieve PASS (59% vs 48%; P = .045), and had higher satisfaction scores (7.4 vs 6.7; P = .024). CONCLUSIONS: Patients with high preop ASES scores achieve less relative improvement; however, these patients may be more likely to achieve PASS and may have higher satisfaction scores postoperatively. LEVEL OF EVIDENCE: Level III, retrospective comparative prognostic trial.

3.
Arthroscopy ; 39(2): 384-389.e6, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-36207000

RESUMO

PURPOSE: To examine the trends in physician professional fees and inpatient and outpatient facility fees in orthopaedic surgery in the United States. METHODS: Physician professional fees and inpatient and outpatient facility fees were tracked from 2008 to 2021 for the most common orthopaedic procedures in each orthopaedic subspecialty. Using common procedure codes for physician and outpatient procedures and Medicare severity diagnosis related group codes for inpatient procedures, the Medicare Physician Fee Schedules were used to obtain the national payment amounts for physician professional fees and inpatient and outpatient facility fees. Trends in fees were tracked over time after adjustment for inflation. RESULTS: From 2008 to 2021, physician professional fees decreased by an average of 20%, whereas inpatient facility fees increased by 15%, and outpatient facility fees increased by 72%. The orthopaedic subspecialty with the largest decrease in physician professional fees was oncology, with an average decrease of 23.5%, followed by general orthopaedics (23.1%), and sports medicine (22.8%). The largest increase in outpatient facility fees was seen in the subspecialties of general orthopaedics (149.8%), spine (130.1%), and trauma (123.0%). CONCLUSIONS: Over the past 13 years, physician professional fees for the most common orthopaedic procedures have declined while inpatient and outpatient facility fees have increased. Understanding these changes is important to the practice of orthopaedic surgery in the United States. LEVEL OF EVIDENCE: IV, economic.


Assuntos
Procedimentos Ortopédicos , Ortopedia , Idoso , Humanos , Estados Unidos , Medicare , Pacientes Internados , Pacientes Ambulatoriais
4.
Ann Surg ; 276(6): e1083-e1088, 2022 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-33914474

RESUMO

OBJECTIVE: To demonstrate the feasibility of implementing a CBE curriculum within a general surgery residency program and to evaluate its effectiveness in improving resident skill. SUMMARY OF BACKGROUND DATA: Operative skill variability affects residents and practicing surgeons and directly impacts patient outcomes. CBE can decrease this variability by ensuring uniform skill acquisition. We implemented a CBE LC curriculum to improve resident performance and decrease skill variability. METHODS: PGY-2 residents completed the curriculum during monthly rotations starting in July 2017. Once simulator proficiency was reached, residents performed elective LCs with a select group of faculty at 3 hospitals. Performance at curriculum completion was assessed using LC simulation metrics and intraoperative operative performance rating system scores and compared to both baseline and historical controls, comprised of rising PGY-3s, using a 2-sample Wilcoxon rank-sum test. PGY-2 group's performance variability was compared with PGY-3s using Levene robust test of equality of variances; P < 0.05 was considered significant. RESULTS: Twenty-one residents each performed 17.52 ± 4.15 consecutive LCs during the monthly rotation. Resident simulated and operative performance increased significantly with dedicated training and reached that of more experienced rising PGY-3s (n = 7) but with significantly decreased variability in performance ( P = 0.04). CONCLUSIONS: Completion of a CBE rotation led to significant improvements in PGY-2 residents' LC performance that reached that of PGY-3s and decreased performance variability. These results support wider implementation of CBE in resident training.


Assuntos
Colecistectomia Laparoscópica , Cirurgia Geral , Internato e Residência , Humanos , Competência Clínica , Estudos de Coortes , Currículo , Cirurgia Geral/educação
5.
J Shoulder Elbow Surg ; 30(6): 1273-1281, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33069903

RESUMO

BACKGROUND: In reverse shoulder arthroplasty, Inferior tilt was originally promoted to decrease rates of baseplate failure. However, the literature is conflicting regarding the effect of tilt on scapular neck impingement, which has been associated with an increased risk of notching, increased risk of impingement-related instability, and decreased range of motion. We hypothesized that inferior tilt of -10° would lead to increased medialization and increased scapular neck impingement compared with 0° of tilt. METHODS: Twenty patients without glenoid bone loss undergoing reverse shoulder arthroplasty (RSA) at a single institution underwent computed tomography scans of the entire scapula and proximal humerus for preoperative planning. For each patient, we digitally implanted a 25-mm glenoid baseplate flush with the inferior rim of the glenoid. We then simulated impingement-free range of motion with 16 different implant configurations: glenoid tilt (0° vs. -10°), baseplate lateralization (0 mm vs. +6 mm), glenosphere size (36 mm vs. 42 mm), and neck-shaft angle (135° vs. 145°). The primary endpoint was external rotation with the arm at the side (ERS), which is the primary mode of both notching and impingement-related instability, and the secondary endpoint was adduction (ADD). We recorded the RSA angle, preoperative scapular neck length (SNL), and postoperative SNL. Data were compared by paired t tests and a multivariable regression analysis. RESULTS: In every simulation, inferior tilt led to more impingement on the scapular neck. Inferior tilt of the glenoid component was associated with a mean 27% decrease in impingement-free external rotation (P < .01 in all cases) and a mean 32% decrease in impingement-free ADD (P < .01 in all cases). Inferior tilt removed 3.2 mm of additional SNL (P < .001). Multivariable regression analysis showed that lateralization had the most impact on impingement-free external rotation and ADD (P < .001), followed by glenosphere size (P < .001), neck-shaft angle (P < .001), postoperative SNL (P < .001), glenoid tilt (P = .001), inclination (P < .001), and RSA angle (P = .023 for ERS and P = .025 for ADD). CONCLUSION: Relative to 0° of tilt of the baseplate, inferior tilt of -10° was associated with increased scapular neck impingement in ERS and ADD, likely a result of the increased medialization necessary to seat an inferiorly tilted implant, which shortens the scapular neck and brings the humerus closer to the scapula. This scapular neck impingement increases the risk of notching and impingement-related instability.


Assuntos
Artroplastia do Ombro , Articulação do Ombro , Artroplastia , Humanos , Amplitude de Movimento Articular , Escápula/diagnóstico por imagem , Escápula/cirurgia , Articulação do Ombro/diagnóstico por imagem , Articulação do Ombro/cirurgia
6.
Ann Surg ; 272(2): 384-392, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32675553

RESUMO

OBJECTIVE: To demonstrate the noninferiority of the fundamentals of robotic surgery (FRS) skills curriculum over current training paradigms and identify an ideal training platform. SUMMARY BACKGROUND DATA: There is currently no validated, uniformly accepted curriculum for training in robotic surgery skills. METHODS: Single-blinded parallel-group randomized trial at 12 international American College of Surgeons (ACS) Accredited Education Institutes (AEI). Thirty-three robotic surgery experts and 123 inexperienced surgical trainees were enrolled between April 2015 and November 2016. Benchmarks (proficiency levels) on the 7 FRS Dome tasks were established based on expert performance. Participants were then randomly assigned to 4 training groups: Dome (n = 29), dV-Trainer (n = 30), and DVSS (n = 32) that trained to benchmarks and control (n = 32) that trained using locally available robotic skills curricula. The primary outcome was participant performance after training based on task errors and duration on 5 basic robotic tasks (knot tying, continuous suturing, cutting, dissection, and vessel coagulation) using an avian tissue model (transfer-test). Secondary outcomes included cognitive test scores, GEARS ratings, and robot familiarity checklist scores. RESULTS: All groups demonstrated significant performance improvement after skills training (P < 0.01). Participating residents and fellows performed tasks faster (DOME and DVSS groups) and with fewer errors than controls (DOME group; P < 0.01). Inter-rater reliability was high for the checklist scores (0.82-0.97) but moderate for GEARS ratings (0.40-0.67). CONCLUSIONS: We provide evidence of effectiveness for the FRS curriculum by demonstrating better performance of those trained following FRS compared with controls on a transfer test. We therefore argue for its implementation across training programs before surgeons apply these skills clinically.


Assuntos
Competência Clínica , Simulação por Computador , Procedimentos Cirúrgicos Robóticos/educação , Treinamento por Simulação/métodos , Especialidades Cirúrgicas/educação , Análise de Variância , Currículo , Feminino , Humanos , Masculino , Medição de Risco , Método Simples-Cego , Resultado do Tratamento
7.
J Arthroplasty ; 35(2): 508-512, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31662280

RESUMO

BACKGROUND: Revision of monoblock metal-on-metal (MoM) total hip arthroplasty (THA) is associated with high complication rates. Limited revision by conversion to a dual mobility (DM) without acetabular component extraction may mitigate these complications. However, the concern for polyethylene wear and osteolysis remains unsettled. This study investigates the results of DM conversion of monoblock MoM THA compared to formal acetabular revision. METHODS: One hundred forty-three revisions of monoblock MoM THA were reviewed. Twenty-nine were revisions to a DM construct, and 114 were complete revisions of the acetabular component. Mean patient age was 61, 54% were women. Components used, acetabular cup position, radiographic outcomes, serum metal ion levels, and HOOS Jr clinical outcome scores were investigated. RESULTS: At 3.9 years of follow-up (range 2-5), there were 2 revisions (6.9%) in the DM cohort, 1 for instability and another for periprosthetic fracture. Among the formal acetabular revision group there was a 20% major complication rate (23/114) and 16% underwent revision surgery (18/114) for aseptic loosening of the acetabular component (6%), deep infection (6%), dislocation (4%), acetabular fracture (3%), or delayed wound healing (6%). In the DM cohort, there were no radiographic signs of aseptic loosening, component migration, or polyethylene wear. One DM patient had a small posterior metadiaphyseal femur lesion that will require close monitoring. There were no other radiographic signs of osteolysis. There were no clinically significant elevations of serum metal ion levels. HOOS Jr scores were favorable. CONCLUSION: Limited revision with conversion to DM is a viable treatment option for failed monoblock MoM THA with lower complication rates than formal revision. Limited revision to DM appears to be a safe option for revision of monoblock MoM THA with a cup in good position and an internal geometry free of sharp edges or articular surface damage. Longer follow-up is needed to demonstrate any potential wear implications of these articulations.


Assuntos
Artroplastia de Quadril , Prótese de Quadril , Próteses Articulares Metal-Metal , Acetábulo/diagnóstico por imagem , Acetábulo/cirurgia , Artroplastia de Quadril/efeitos adversos , Feminino , Seguimentos , Prótese de Quadril/efeitos adversos , Humanos , Masculino , Próteses Articulares Metal-Metal/efeitos adversos , Metais , Desenho de Prótese , Falha de Prótese , Reoperação , Estudos Retrospectivos
8.
J Arthroplasty ; 35(4): 1069-1073, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-31870582

RESUMO

BACKGROUND: Extensive femoral bone loss poses a challenge in revision total hip arthroplasty (rTHA). Many techniques have been developed to address this problem including fully porous cylindrical stems, impaction bone grafting, and cementation of long stems, which have had varied success. Modular tapered fluted femoral stems (MTFS) show favorable results. We sought to determine the minimum 2-year radiographic and clinical performance of MTFS in rTHA in a population with extensive proximal femoral bone loss. METHODS: Our clinical database was queried retrospectively for all patients who underwent rTHA with an MTFS. We included patients with Paprosky 3 and 4 femoral bone loss and patients with Vancouver B2 and B3 periprosthetic femur fractures. Patients without 2-year follow-up were invited to return to clinic for X-ray evaluation and to complete clinical questionnaires. We assessed distance of stem subsidence and presence of stem fixation on final X-ray. We recorded all-cause revision and survival of the stem at final follow-up. RESULTS: One hundred twenty-nine patients were available for follow-up. Average follow-up time was 3.75 years. One hundred twenty-two stems (95%) remained in place at final follow-up. Median subsidence was 1.4 mm (range 0-21). All-cause revision rate was 16.3% (21 patients). Of the hips revised, 10 were for instability, 6 for infection, 1 for aseptic loosening, and 1 for periprosthetic femur fracture. Three were revised for other reasons. The stem was revised in 7 patients (5.4%), and the most common reason for stem revision was infection (5 patients). The other 2 stems were revised for aseptic loosening in a Paprosky 4 femur and periprosthetic femur fracture. Survival of tapered modular fluted stems with aseptic failure as an endpoint was 98.4%. The mean Hip disability and Osteoarthritis Outcome Score, Joint Replacement score at final follow-up was 73, and mean Veterans Rand 12 item health survey physical and mental scores were 32.8 and 52.2, respectively. CONCLUSION: In patients with Paprosky 3, 4 femoral defects or Vancouver type B2, B3 fractures, modular tapered fluted stems for femoral revision show excellent outcomes at minimum 2-year follow-up.


Assuntos
Artroplastia de Quadril , Fraturas do Fêmur , Prótese de Quadril , Fraturas Periprotéticas , Artroplastia de Quadril/efeitos adversos , Fraturas do Fêmur/diagnóstico por imagem , Fraturas do Fêmur/cirurgia , Fêmur/diagnóstico por imagem , Fêmur/cirurgia , Prótese de Quadril/efeitos adversos , Humanos , Fraturas Periprotéticas/diagnóstico por imagem , Fraturas Periprotéticas/epidemiologia , Fraturas Periprotéticas/etiologia , Desenho de Prótese , Reoperação , Estudos Retrospectivos , Resultado do Tratamento
9.
J Arthroplasty ; 35(9): 2363-2366, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32451280

RESUMO

BACKGROUND: Advances in technique and perioperative blood management have improved transfusion rates following unilateral primary total joint arthroplasty and led some centers to change their preoperative blood ordering protocols. The purpose of this study is to determine whether deleting type and screens (T&S) from preoperative order sets was safe for patients undergoing primary total knee (TKA) and total hip arthroplasty (THA) and to identify patients who required allogenic blood transfusion. METHODS: Prospectively collected data were reviewed to identify any patient with a hemoglobin (Hgb) drawn within 30 days of surgery who received a transfusion following a unilateral primary TKA or THA. RESULTS: A total of 1255 patients met inclusion criteria. Of the total, 682 (54%) were TKAs and 573 (46%) were THAs. The mean preoperative Hgb was 11.5 g/dL with an average delta Hgb of 3.6 g/dL on postoperative day 1. No patient required an intraoperative transfusion. Fourteen patients (mean age and body mass index, 67.9 and 29.0) required a transfusion (1.1%) for postoperative blood loss anemia. Of those transfused, 13 (93%) of the patients underwent THA with the mean estimated blood loss of 378.6 mL. The total cost for a patient obtaining a T&S is $191.27. CONCLUSION: In our series, the risk of blood transfusion was rare (1.1%) and occurred only secondary to postoperative blood loss anemia. There were no cases of intraoperative complication requiring urgent or emergent blood transfusion. Removing T&S from standard order sets for patients undergoing primary TKA or THA appears to be a safe and cost-effective practice.


Assuntos
Antifibrinolíticos , Artroplastia de Quadril , Artroplastia do Joelho , Ácido Tranexâmico , Antifibrinolíticos/uso terapêutico , Artroplastia de Quadril/efeitos adversos , Artroplastia do Joelho/efeitos adversos , Perda Sanguínea Cirúrgica , Transfusão de Sangue , Humanos , Estudos Retrospectivos
10.
J Arthroplasty ; 33(7): 2177-2181, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29605150

RESUMO

BACKGROUND: We sought to evaluate the outcomes of cementless acetabular components used in patients with Crowe II and III dysplasia, and to compare outcomes between cups placed within vs outside of an "anatomic" zone. Our specific aims were to (1) plot hip centers in these patients at our institution to characterize "anatomic" vs "nonanatomic" positions, (2) evaluate the association between hip center and radiographic loosening, (3) determine whether hip center was associated with acetabular component revision, and (4) compare patient-reported outcome scores between groups. METHODS: We retrospectively reviewed 88 primary cementless total hip arthroplasties at a mean follow-up of 10 years (range 2-26 years). Patients were 85% female, with a mean age of 44 years (range 28-61 years) and a body mass index of 27 kg/m2 (range 19-42 kg/m2). Medical records and radiographs were reviewed, and a survey was conducted for all patients. Anatomic hip center was defined using the 4-zone system, wherein centers are "anatomic" if they are <1 cm superior and <1 cm lateral to the approximate femoral head center. Cox proportional analyses were used to compare outcomes between groups. RESULTS: Seventy hips (80%) had an anatomic hip center. Anatomic hips had a lower incidence of radiographic acetabular loosening (0% vs 17%, P = .007) and cup revision (0% vs 28%, P = .0002). There were no differences in Hip Disability and Osteoarthritis Outcome and Joint Replacement Scores (96.2 ± 5 vs 91.9 ± 12, P = .7). CONCLUSION: The incidence of aseptic loosening and cup revision were lower when hip center was <1 cm superior and 1 cm lateral to the approximate femoral head center.


Assuntos
Artroplastia de Quadril/normas , Luxação Congênita de Quadril/cirurgia , Prótese de Quadril/efeitos adversos , Falha de Prótese/etiologia , Acetábulo/cirurgia , Adulto , Feminino , Cabeça do Fêmur/cirurgia , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia , Estudos Retrospectivos , Resultado do Tratamento
11.
J Arthroplasty ; 33(11): 3496-3501, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30150153

RESUMO

BACKGROUND: The position of the acetabular component in total hip arthroplasty (THA) is critical for success. However, this remains the most variable aspect of the surgery. We hypothesized that there is wide variation in pelvic orientation in the lateral decubitus position. We sought to determine the variability in pelvic positioning and the frequency of pelvic malposition during THA in lateral decubitus with regard to pelvic tilt and pelvic rotation. METHODS: We analyzed preoperative standing and intraoperative anteroposterior pelvis X-rays in 248 consecutive THAs performed in lateral decubitus by one surgeon. Pelvic tilt and rotation were determined for preoperative and intraoperative X-rays. Proper intraoperative positioning was defined as less than 10° change in tilt or rotation between preoperative and intraoperative X-rays. RESULTS: With regard to pelvic tilt, the intraoperative position was proper in 188 (76%) cases. There was a pelvic tilt discrepancy of 10°-20° in 43 (17.5%) cases and greater than 20° in 16 (6.5%) patients. With regard to pelvic rotation, the intraoperative position was proper in 202 (81%) cases. There was a pelvic rotation discrepancy of 10°-20° in 38 (15.4%) cases and greater than 20° in 7 (2.8%) cases. In 248 cases, only 154 (62.1%) had intraoperative positioning within 10° of preoperative tilt and axial rotation. Pelvic malposition occurred in 38% of cases overall. CONCLUSION: There is wide variation in pelvic orientation in lateral decubitus and frequent discrepancy in pelvic tilt and rotation between preoperative and intraoperative anteroposterior X-rays. Anatomic landmarks should be used to guide acetabular component positioning. LEVEL OF EVIDENCE III: Diagnostic.


Assuntos
Artroplastia de Quadril/métodos , Posicionamento do Paciente , Ossos Pélvicos/diagnóstico por imagem , Acetábulo/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pelve , Postura , Radiografia , Rotação
12.
Adv Funct Mater ; 27(47)2017 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-30349427

RESUMO

Clinical application of injectable, thermoresponsive hydrogels is hindered by lack of degradability and controlled drug release. To overcome these challenges, a family of thermoresponsive, ABC triblock polymer-based hydrogels has been engineered to degrade and release drug cargo through either oxidative or hydrolytic/enzymatic mechanisms dictated by the "A" block composition. Three ABC triblock copolymers are synthesized with varying "A" blocks, including oxidation-sensitive poly(propylene sulfide), slow hydrolytically/enzymatically degradable poly(ε-caprolactone), and fast hydrolytically/enzymatically degradable poly(D,L-lactide-co-glycolide), forming the respective formulations PPS135-b-PDMA152-b-PNIPAAM225 (PDN), PCL85-b-PDMA150-b-PNIPAAM150 (CDN), and PLGA60-b-PDMA148-b-PNIPAAM152 (LGDN). For all three polymers, hydrophilic poly(N,N-dimethylacrylamide) and thermally responsive poly(N-isopropylacrylamide) comprise the "B" and "C" blocks, respectively. These copolymers form micelles in aqueous solutions at ambient temperature that can be preloaded with small molecule drugs. These solutions quickly transition into hydrogels upon heating to 37 °C, forming a supra-assembly of physically crosslinked, drug-loaded micelles. PDN hydrogels are selectively degraded under oxidative conditions while CDN and LGDN hydrogels are inert to oxidation but show differential rates of hydrolytic/enzymatic decomposition. All three hydrogels are cytocompatible in vitro and in vivo, and drug-loaded hydrogels demonstrate differential release kinetics in vivo corresponding with their specific degradation mechanism. These collective data highlight the potential cell and drug delivery use of this tunable class of ABC triblock polymer thermogels.

13.
J Arthroplasty ; 32(11): 3468-3473, 2017 11.
Artigo em Inglês | MEDLINE | ID: mdl-28697864

RESUMO

BACKGROUND: Metaphyseal bone loss is commonly encountered in revision total knee arthroplasty (TKA). Anderson Orthopaedic Research Institute types 2 and 3 defects generally require some form of metaphyseal fixation or augmentation. This study evaluates the midterm results of stepped, porous-coated metaphyseal sleeves in revision TKA in the setting of severe bone loss. METHODS: Patients who underwent revision TKA using metaphyseal sleeves from March 2006 to May 2014 at our institution were identified from a prospective research database. Preoperative patient characteristics and operative data were reviewed. Postoperative outcomes were compared with preoperative values. Primary study outcomes included complications, reoperations, radiographic assessment of sleeve osteointegration, and survivorship. RESULTS: One hundred sixteen knees (108 patients) underwent revision TKA with 152 metaphyseal sleeves (111 tibial and 41 femoral). Anderson Orthopaedic Research Institute defect classification included 5 type 2A, 89 type 2B, and 17 type 3 tibial defects; and 3 type 2A, 34 type 2B, and 4 type 3 femoral defects. There were 3 intraoperative fractures (1.9%) associated with sleeve preparation and/or insertion. Six knees (5 patients) were lost to follow-up and 5 patients (6 knees) died before 2 years. Of the remaining 104 knees (98 patients, 134 sleeves), mean follow-up was 5.3 years (range 2-9.6 years). Nineteen knees (16.4%) required reoperation, most commonly for recurrent infection. Only one sleeve demonstrated radiographic evidence of failed osteointegration, but did not require revision. Two sleeves (1.5%) required removal and/or resection for recurrent infection. CONCLUSION: This large retrospective series illustrates the utility of porous metaphyseal sleeves in revision TKA with a low rate of intraoperative complications, excellent osteointegration, and long-term fixation.


Assuntos
Artroplastia do Joelho/instrumentação , Fêmur/cirurgia , Reoperação/instrumentação , Tíbia/cirurgia , Artroplastia do Joelho/métodos , Feminino , Humanos , Prótese do Joelho , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Desenho de Prótese , Reoperação/métodos , Estudos Retrospectivos
14.
J Arthroplasty ; 32(3): 836-842, 2017 03.
Artigo em Inglês | MEDLINE | ID: mdl-27816367

RESUMO

BACKGROUND: Biomechanical studies have suggested improved stress distribution in metal-backed (MB) compared to all-polyethylene (AP) tibias, but such potential benefits have not been realized clinically. The purpose of this investigation was to analyze the outcomes of AP components in patients with primary osteoarthritis and compare the results to those obtained with MB tibial components in total knee arthroplasty (TKA). METHODS: We reviewed 11,653 patients undergoing primary TKA for osteoarthritis. There were 9999 (86%) MB (8470 modular and 1529 monoblock) and 1654 (14%) AP tibial components. All patients had at least 2 years of clinical follow-up with mean follow-up of 8 years (range, 2-30 years). RESULTS: Mean survivorship for all primary TKAs at the 5-year, 10-year, 15-year, and 20-year time points was 97%, 92%, 86%, and 78%. AP tibial components were found to have improved survivorship when compared to modular and monoblock MB counterparts (P < .0001). Likewise, AP tibial components were found to have lower rates of tibial component loosening (P < .0001), tibial osteolysis, and component fracture. Furthermore, the AP group had improved survival rates in most age-groups except <55 years where there was no difference. AP tibial components demonstrated improved survival for all body mass index (BMI) groups except in patients with a BMI ≤25 kg/m2 where there was no difference. CONCLUSION: AP tibial components had significantly improved implant survival across all age-groups and most BMI categories in patients who underwent TKA for osteoarthritis. Given these outcomes, AP tibias are a reasonable option, regardless of patient age and BMI.


Assuntos
Artroplastia do Joelho/instrumentação , Prótese do Joelho/estatística & dados numéricos , Osteoartrite do Joelho/cirurgia , Desenho de Prótese , Tíbia/cirurgia , Idoso , Índice de Massa Corporal , Doenças das Cartilagens/cirurgia , Feminino , Humanos , Masculino , Minnesota/epidemiologia , Osteoartrite/cirurgia , Polietileno , Infecções Relacionadas à Prótese/epidemiologia , Reoperação/estatística & dados numéricos
16.
Clin Orthop Relat Res ; 474(4): 915-25, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25809874

RESUMO

BACKGROUND: Although much attention has been paid to the role of deliberate practice as a means of achieving expert levels of performance in other medical specialties, little has been published regarding its role in maximizing orthopaedic surgery resident potential. As an initial step in this process, this study seeks to determine how residents and program directors (PDs) feel current time spent in training is allocated compared with a theoretical ideal distribution of time. QUESTIONS/PURPOSES: According to residents and PDs, (1) how do resident responsibilities change by level of training as perceived and idealized by residents and PDs? (2) How do resident and PD perceptions of current and ideal time distributions compare with one another? (3) Do the current training structures described by residents and PDs differ from what they feel represents an ideal time allocation construct that maximizes the educational value of residency training? METHODS: A survey was sent to orthopaedic surgery resident and PD members of the Midwest Orthopedic Surgical Skills Consortium asking how they felt residents' time spent in training was distributed across 10 domains and four operating room (OR) roles and what they felt would be an ideal distribution of that time. Responses were compared between residents and PDs and between current schedules and ideal schedules. RESULTS: Both residents and PDs agreed that time currently spent in training differs by postgraduate year with senior-level residents spending more time in the OR (33.7% ± 8.3% versus 17.9% ± 6.2% [interns] and 27.4% ± 10.2% [juniors] according to residents, p < 0.001; and 38.6% ± 8.1% versus 11.8% ± 6.4% [interns] and 26.1% ± 5.7% [juniors] according to PD, p < 0.001). The same holds true for their theoretical ideals. Residents and PDs agree on current resident time allocation across the 10 domains; however, they disagree on multiple components of the ideal program with residents desiring more time spent in the OR than what PDs prefer (residents 40.3% ± 10.3% versus PD 32.6% ± 14.6% [mean difference {MD}, 7.7; 95% confidence interval {CI}, 4.4, 11.0], p < 0.001). Residents would also prefer to have more time spent deliberately practicing surgical skills outside of the OR (current 1.8% ± 2.1% versus ideal 3.7% ± 3.2% [MD, -1.9; 95% CI, -.2.4 to -1.4], p < 0.001). Both residents and PDs want residents to spend less time completing paperwork (current 4.4% ± 4.1% versus ideal 0.8% ± 1.6% [MD, 3.6; 95% CI, 3.0-4.2], p < 0.001 for residents; and current 3.6% ± 4.1% versus ideal 1.5% ± 1.9% [MD, 2.1; 95% CI, 0.9-3.3], p < 0.001 for PDs). CONCLUSIONS: Residents and PDs seem to agree on how time is currently spent in residency training. Some differences of opinions continue to exist regarding how an ideal program should be structured; however, this work identifies a few potential targets for improvement that are agreed on by both residents and PDs. These areas include increasing OR time, finding opportunities for deliberate practice of surgical skills outside of the OR, and decreased clerical burden. This study may serve as a template to allow programs to continue to refine their educational models in an effort to achieve curricula that meet the desired goals of both learners and educators. Additionally, it is an initial step toward more objective identification of the optimal educational structure of an orthopaedic residency program.


Assuntos
Atitude do Pessoal de Saúde , Educação de Pós-Graduação em Medicina/organização & administração , Docentes de Medicina , Internato e Residência/organização & administração , Procedimentos Ortopédicos/educação , Melhoria de Qualidade/organização & administração , Ensino/organização & administração , Gerenciamento do Tempo/organização & administração , Currículo , Educação de Pós-Graduação em Medicina/métodos , Educação de Pós-Graduação em Medicina/normas , Humanos , Internato e Residência/normas , Procedimentos Ortopédicos/normas , Percepção , Avaliação de Programas e Projetos de Saúde , Melhoria de Qualidade/normas , Inquéritos e Questionários , Ensino/métodos , Ensino/normas , Fatores de Tempo , Estados Unidos
18.
J Arthroplasty ; 31(10): 2247-51, 2016 10.
Artigo em Inglês | MEDLINE | ID: mdl-27471210

RESUMO

BACKGROUND: The identification of suspected pelvic discontinuity is important for preoperative planning in revision hip arthroplasty. Computed tomography (CT) of the pelvis with reconstructions in the axial, sagittal, and coronal planes has been previously described for the identification of pelvic discontinuity but fails to show some discontinuities. The purpose of this study was to determine whether reformatted 45° oblique CT scans of the pelvis, similar in projection to Judet views on plain films, provide advantages in detecting pelvic discontinuity preoperatively over standard reconstruction CT scans. We describe a new technique of reformatting conventional CT scans to present 45° oblique views of the pelvis. METHODS: Using an institutional joint registry, we retrospectively identified 22 patients who had intraoperative findings of pelvic discontinuity and also had a preoperative CT scan of the pelvis. The criterion for diagnosis of pelvic discontinuity was a continuous visible fracture line involving the entire width of the anterior and posterior columns. RESULTS: In this study, standard reconstruction CT scans were 73% sensitive in identifying discontinuity based on these parameters and the addition of reformatted 45° oblique CT scans increased sensitivity to 91%. CONCLUSION: Unique reconstructive techniques in revision hip arthroplasty can be used, and the operative plan may be modified if pelvic discontinuity is identified preoperatively. CT scans of the pelvis with reconstructions at 45° iliac oblique and obturator oblique views in patients with suspected pelvic discontinuity provide a high level of sensitivity when the diagnosis cannot be firmly established from plain films.


Assuntos
Acetábulo/diagnóstico por imagem , Artroplastia de Quadril/efeitos adversos , Fraturas Ósseas/diagnóstico por imagem , Complicações Pós-Operatórias/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Acetábulo/cirurgia , Humanos , Ossos Pélvicos , Complicações Pós-Operatórias/etiologia , Cuidados Pré-Operatórios , Radiografia , Reoperação , Estudos Retrospectivos
19.
J Arthroplasty ; 31(12): 2814-2818, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27436501

RESUMO

BACKGROUND: Predisposing factors for trunnionosis and elevated metal ion levels in metal-on-polyethylene (MOP) total hip arthroplasty (THA) are currently unknown. METHODS: This retrospective cohort study enrolled 80 consecutive patients (43 males) with an asymptomatic MOP THA at 2- to 5-year follow-up and no other metal implants. Serum cobalt (Co) and chromium (Cr) levels were collected at the time of enrollment, and retrospective review was performed regarding demographic, implant, and surgical characteristics. Mean age at the time of surgery was 65.7 years (range 35.6-85.9 years), and mean postoperative follow-up was 28.7 months (range 24.4-58.9 months). RESULTS: Femoral head offset was the only evaluated factor shown to increase serum Co ion levels above baseline within the cohort. Mean difference in Co level for high and low offset implants was 0.58 ppb (95% confidence interval [CI] = 0.05-1.11 ppb; P = .03). Mean difference in Cr level for high and low offset implants was 0.19 ppb (95% CI = -0.23 to 0.60 ppb; P = .37). Mean difference in Co level for small and large femoral heads was 0.20 ppb (95% CI = -0.41 to 0.81 ppb; P = .59). Mean difference in Cr level for small and large femoral heads was 0.28 ppb (95% CI = -0.18 to 0.74 ppb; P = .06). Age, gender, Harris Hip Score, and implant duration were not associated with changes in metal ion levels. CONCLUSION: Femoral head offset appears to be an important source of elevated metal ion levels in MOP THA. Further studies will be needed to understand if increasing femoral head offset is associated with subsequent adverse local tissue reactions.


Assuntos
Artroplastia de Quadril/efeitos adversos , Cromo/sangue , Cobalto/sangue , Prótese de Quadril/efeitos adversos , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Cabeça do Fêmur , Humanos , Masculino , Metais/sangue , Pessoa de Meia-Idade , Polietileno , Período Pós-Operatório , Estudos Retrospectivos
20.
J Arthroplasty ; 30(12): 2110-5, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26115983

RESUMO

The purpose of this study was to evaluate the accuracy and efficiency of three patellar resection techniques: cutting guide, free hand with haptic feedback, and a novel technique utilizing four quadrant measurements. Ninety patients undergoing TKA were randomized to receive patellar resurfacing by one of the three study techniques. The novel four quadrant technique resulted in least post-resection asymmetry (0.85 mm, P = 0.001). The most accurate methods for obtaining desired thickness were haptic feedback (0.66 mm mean discrepancy [MD]) and novel four quadrant technique (0.66 mm MD) followed by the patellar cutting guide (1.40 mm MD) (P < 0.001). Use of a patellar cutting guide resulted in increased patellar asymmetry and decreased accuracy in obtaining desired patellar thickness in this prospective trial.


Assuntos
Artroplastia do Joelho/métodos , Patela/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA