Developmental Defects of Enamel: A Bibliometric Analysis of the Top 100 Most-Cited Papers.

BACKGROUND: Developmental defects of enamel (DDE) are a result of disturbances during formation and maturation of the enamel. Evaluating the most-cited DDE papers can provide important tools that point to the gaps and strengths of this important topic in dentistry. SUMMARY: This bibliometric study analyzed the 100 most-cited papers on DDE. Using a combined keyword search strategy, the 100 most-cited papers were selected in the Web of Science Core Collection. Papers that addressed any type of DDE were included. The extracted data were title, number of citations, study theme, authorship, journal, type of DDE, type of dentition (primary or permanent), type of diagnosis, study design, year, and country of publication. The bibliometric networks were generated through VOSviewer software. The 100 papers had a range from 78 to 459 citations. The main themes of studies were etiopathogenesis (53%), prevalence and incidence (22%), and diagnosis (8%). The authors with the highest number of citations were Goodman AH and Rose JC (459 citations). Most articles were published in dental journals (47%). The most studied types of DDE were fluorosis and amelogenesis imperfecta in the permanent dentition (47%). Observational (24%) and non-systematic reviews (24%) were the most common study designs and ranged from 1977 to 2019. The country with the highest number of publications was the USA (41%). KEY MESSAGES: Most of the top 100 DDE papers were about fluorosis and amelogenesis imperfecta, with top papers from three continents with English as the native language. This topic is of great importance in dentistry, and the need for further studies is highlighted, especially regarding the diagnosis and treatment of some DDEs.

Passive smoking and early childhood caries: when adult addiction affects children's oral health.

DATA SOURCES: Medline via EBSCOhost, PubMed, and Scopus up to February 2023. STUDY SELECTION: Observational studies in the English language published in peer-reviewed journals, encompassing children aged 0 to 6 years exposed to environmental tobacco smoke and passive smoking, with a focus on oral health conditions in deciduous dentition. DATA EXTRACTION AND SYNTHESIS: Data were extracted from 25 papers, encompassing study details, oral health, and smoking exposure. Confounding factors such as parental education, income, diet, fluoride exposure, gender, and oral hygiene practices were also identified. The risk of bias was assessed using the Newcastle-Ottawa Scale (NOS). Frequency effect size was calculated for health variables and smoking exposure. RESULTS: Most studies identified a correlation between passive smoking and an increased prevalence of dental caries. Environmental tobacco smoke exposure and dental caries risk were influenced by factors such as low parental education, socioeconomic status, dietary habits, oral hygiene, and gender. CONCLUSIONS: The results of this systematic review strongly indicate a significant association between dental caries in deciduous dentition and passive smoking.

A Bibliometric Analysis of the Top 100 Most-Cited Papers Concerning Dental Fluorosis.

A high number of citations can indicate the potential of any specific paper to influence other research and generate changes in clinical practice. Analyzing the most-cited papers in a certain scientific field may assist researchers to identify the influential papers as well their main characteristics. The present study aimed to analyze the 100 most-cited papers concerning dental fluorosis (DF) through a bibliometric review. A search was performed in the Web of Science Core Collection (WoS-CC) database in November 2021. The papers were displayed in descending order according to the number of citations in WoS-CC. Two independent researchers performed the selection. Scopus and Google Scholar were used to compare the number of citations with WoS-CC. The following data were extracted from the papers: title, authors, number and density of citations, institution, country, continent, year of publication, journal title, keywords, study design, and theme. Collaborative networks were generated using the VOSviewer software. The top 100 most-cited papers were published between 1974 and 2014 and were cited 6,717 times (ranging from 35 to 417). Community Dentistry and Oral Epidemiology (24%), Journal of Dental Research (21%), Journal of Public Health Dentistry (17%), and Caries Research (13%) published the most papers. Observational studies (60%) and literature reviews (19%) were the most common study designs. The main topics were epidemiology (44%) and fluoride intake (32%). The countries with the highest number of papers were the USA (44%), Canada (10%), and Brazil (9%). The University of Iowa (USA) had the most papers (12%). Levy SM was the author with the highest number of papers (12%). The 100 most-cited papers on DF were mainly observational studies focused on epidemiology and originated in North America. There were few interventional studies and systematic reviews among the most-cited papers concerning this topic.

Which dental and psychosocial factors may predict bullying occurrence in adolescence?

DESIGN: Cohort study. STUDY POPULATION: 639 preschool children at baseline (T1) and 429 adolescents at follow-up (T2). OUTCOME MEASURES: Oral health conditions (untreated dental caries, dental trauma and malocclusion, sense of coherence (SOC), self-perception of dental treatment needs, general and dental bullying. DATA ANALYSIS: Chi-square test, t-test, structural equation modeling, goodness of fit. RESULTS: Untreated dental caries and low socioeconomic status impacted the occurrence of both general and dental bullying. SOC and self-perceived dental treatment need were also important factors in the occurrence of bullying. CONCLUSIONS: The oral health condition that most impacted bullying episodes both directly and indirectly was untreated dental caries. Socioeconomic status was also an important cumulative predictor of the occurrence of episodes of bullying.

Retention in fissure resin-based sealants in schoolchildren: the etching step importance.

DESIGN: Randomized controlled trial. STUDY POPULATION: Forty-seven schoolchildren aged 9-10 years with fully sound/noncavitated erupted first permanent molars were included and randomly allocated in control and experimental groups in a split-mouth design. CASES: 47 schoolchildren (94 molars) fissure sealants applied using self-etch universal adhesive system. CONTROLS: 47 schoolchildren (94 molars) fissure sealants applied using conventional acid-etching technique. OUTCOME MEASURE: Retention of sealants and secondary caries incidence (ICDAS). DATA ANALYSIS: Chi-square test. RESULTS: Conventional acid-etch sealants retention was superior to self-etch after 6 and 24 months (p < 0.001), but no differences were found in caries incidence after 6 and 24 months (p > 0.05). CONCLUSIONS: Clinical retention of fissure sealants using conventional acid-etch technique is greater than self-etch.

Altered heart cytokine profile and action potential modulation in cardiomyocytes from Mas-deficient mice.

The renin-angiotensin system (RAS) is a key hormonal system. In recent years, the functional analysis of the novel axis of the RAS (ACE2/Ang-(1-7)/Mas receptor) revealed that its activation can become protective against several pathologies, including cardiovascular diseases. Mas knockout mice (Mas-KO) represent an important tool for new investigations. Indeed, extensive biological research has focused on investigating the functional implications of Mas receptor deletion. However, although the Mas receptor was identified in neonatal cardiomyocytes and also in adult ventricular myocytes, only few reports have explored the Ang-(1-7)/Mas signaling directly in cardiomyocytes to date. This study investigated the implication of Mas receptor knockout to the cytokine profile, energy metabolism, and electrical properties of mice-isolated cardiomyocytes. Here, we demonstrated that Mas-KO mice have modulation in some cytokines, such as G-CSF, IL-6, IL-10, and VEGF in the left ventricle. This model also presents increased mitochondrial number in cardiomyocytes and a reduction in the myocyte diameter. Finally, Mas-KO cardiomyocytes have altered action potential modulation after diazoxide challenge. Such electrical finding was different from the data showed for the TGR(A1-7)3292 (TGR) model, which overexpresses Ang-(1-7) in the plasma by 4.5, used by us as a control. Collectively, our findings exemplify the importance of understanding the ACE2/Ang-(1-7)/Mas pathway in cardiomyocytes and heart tissue. The Mas-KO mice model can be considered an important tool for new RAS investigations.

The Top 100 Most-Cited Papers in Erosive Tooth Wear: A Bibliometric Analysis.

Citation rates can be used as an indicator of the influence and relevance of scientific papers. The present study analyzed the 100 most-cited articles related to erosive tooth wear (ETW). The top 100 most-cited papers focusing on ETW topics were collected from the Web of Science database on November 11, 2020. The following bibliometric data were extracted from papers: title, authorship, institutions, countries, number of citations, year of publication, journal title, study design, topic, and keywords. Scopus and Google Scholar were searched to compare the number of citations. The VOSviewer software was used to generate collaborative network maps for the authors and keywords. The number of citations of the 100 most-cited papers ranged from 71 to 330 (average: 97.44). The papers were published between 1949 and 2015. Caries Research (28%) and The Journal of Dentistry (16%) presented the majority of papers. Laboratorial (44%) and observational studies (33%) were the most common study designs. The most studied topics were epidemiology (31%) and the erosive potential of substances (drinks, foods, or medicines) (22%). The countries with the highest number of most-cited papers were England (32%), Germany (18%), and Switzerland (10%). The University of Bern was the institution with the most papers (10%). Lussi A was the author with the highest number of papers in the top 100 (14%). The most common keyword was "dental erosion" with 64 occurrences. The top 100 most-cited papers related to ETW were composed mainly of laboratorial and observational studies focusing on epidemiology and the erosive potential of substances.

Prevalence of toothache and associated factors in children and adolescents: a systematic review and meta-analysis.

OBJECTIVES: This systematic review aimed to determine the pooled prevalence of toothache in children and adolescents and to verify its association with sociodemographic characteristics and dental caries experience. MATERIAL AND METHODS: Six main and three grey literature databases were searched in February 2021. Observational studies that assessed the prevalence of toothache and associated factors were included. The methodological quality of the studies was evaluated following the guidelines by Fowkes and Fulton. Proportion and association meta-analyses were performed in MedCalc and Revman software, respectively. The certainty of the evidence was determined with the GRADE approach. RESULTS: Seventy-one studies met the inclusion criteria. Thirty-two presented high methodological quality and a low risk of bias. The overall pooled prevalence of toothache in children and adolescents was 36.2% (95%CI: 33.0-39.42; I2: 99.72%; P < 0.001). Females (OR: 1.17; 95%CI: 1.08-1.26; I2: 91%; P < 0.001) and children and adolescents whose caregivers had ≤ 8 years of schooling (OR: 1.42; 95%CI: 1.30-1.56; I2: 77%; P < 0.001) presented the higher chance of reporting toothache. Dental caries experience increased the chance of reporting toothache in 3.49 times (95%CI: 2.70-4.51; I2: 92%; P < 0.001). The certainty of the evidence was very low. CONCLUSIONS: The overall pooled prevalence of toothache was considered high. Sociodemographic characteristics (sex and caregivers' educational level) and previous dental caries experience were significantly associated with toothache reports. CLINICAL RELEVANCE: Toothache is still a recurrent issue in many countries. Thus, it is essential to understand its possible associated factors to reduce the occurrence of new episodes.

The Top 100 Most-Cited Papers in Cariology: A Bibliometric Analysis.

A highly cited paper is seen as a landmark in any field and can influence both research and clinical practice. This study aimed to quali-quantitatively analyze the 100 most-cited papers in Cariology. A search strategy was first determined using specific keywords related to the field. A comprehensive search was then conducted in the Thompson Reuters Web of Science citation indexing database up to April 2019. Papers focused on any aspect of Cariology were included. A panel of 4 researchers conducted the selection of papers and extracted data on the number of citations, title, authors, country, year, journals, study design, and topic of interest. Scopus and Google Scholar were also searched to compare the number of citations. The VOSviewer software was used to generate bibliometric networks. The number of citations among the top 100 most-cited papers ranged from 168 to 1,961 with a mean of 292,66. Three papers had more than 1,000 citations. The Journal of Dental Research (20%) and Caries Research (17%) had more top papers. The oldest and the most recent papers were published in 1960 and 2015. Literature reviews (35%) and laboratorial studies (31%) were the most common study designs. The countries with the highest number of most-cited papers were the USA (40%), Sweden (10%), and Japan (9%). The most studied fields of interest were etiology/pathogenesis (41%) and prevention (20%). VOSviewer maps revealed collaborative networks between countries and organizations. The top 100 most-cited papers in Cariology were published mainly by European and Anglo-Saxon American authors and were composed mainly of literature reviews with etiology/pathogenesis as the most frequent topic of interest.

The top 100 most-cited papers authored by Dr. Jens Ove Andreasen: A bibliometric analysis.

BACKGROUND/AIM: Dr. Jens Ove Andreasen, the "father" of dental traumatology, passed away on September 26, 2020. As a tribute, the aim of this study was to catalog and analyze the top 100 most-cited papers (co)authored by Dr. Andreasen. MATERIALS AND METHODS: A bibliometric analysis was conducted on October 21, 2020, in the Web of Science Core Collection (WoS-CC) database. The numbers of citations in the WoS "All Databases" section, Scopus, and Google Scholar databases were cross-matched. Two researchers collected the following bibliometric data: title, number of citations, authors, country, year, journals, study design, and theme. The VOSviewer software was used to generate collaborative network maps for the authors and keywords. RESULTS: Of 194 papers identified in WoS-CC, a list was compiled with the 100 most-cited papers (co)authored by Dr. Andreasen. The number of citations of each paper ranged from 24 to 365 (mean: 85.4). Nine papers were cited more than 200 times. Most papers were published in Dental Traumatology (55%), between the 1990's and 2000's (60%), with a laboratory design (40%). One hundred and nine (co)authors, from 19 countries were identified in the top 100 most-cited papers. Dental traumatology was the most studied theme (52%). CONCLUSIONS: The top 100 most-cited papers (co)authored by Dr. Jens Ove Andreasen were composed mainly of laboratory and observational studies, published mostly in Dental Traumatology. The present study was a humble homage to highlight the importance of his research and work. However, his legacy goes beyond the numbers and will always remain unsurpassed.

Early childhood caries and oral health-related quality of life of Brazilian children: Does parents' resilience act as moderator?

BACKGROUND: Early childhood caries (ECC) is the most common chronic disease in childhood. Measures to reduce the prevalence of ECC cannot be taken without recognizing that oral health is influenced by biopsychosocial factors on individual and community levels. AIM: To evaluate the impact of ECC on OHRQoL and moderation effect of parents' resilience. DESIGN: Population-based, cross-sectional study with 497 children (4-6 years old) at preschools in Ribeirão das Neves, MG, Brazil. Parents self-completed the Brazilian version of the early childhood oral health impact scale (B-ECOHIS), the Resilience Scale and questionnaires about socioeconomic and oral health behaviour factors. Calibrated dentists conducted examinations for ECC (ICDASepi) and pulp consequences (pufa). Data analysis used multivariate Poisson regression for complex sample (P < .05). RESULTS: Model#1, adjusted for parents' resilience and socioeconomic factors, revealed that preschoolers with pulp involvement had 2.36 (95% CI: 1.60-3.49) and fistula/abscess had 3.57 (95% CI: 2.23-5.72) more prevalence of negative impact on OHRQoL than preschoolers with ECC without pulp consequences. In Model#2, resilience was removed from the analysis and the strength of associations almost did not change (OHRQoL vs pulp involvement RP = 2.33;95% CI: 1.58-3.43; OHRQoL vs fistula/abscess RP = 3.65;95% CI: 2.22-5.99). CONCLUSION: Early childhood caries with pulp consequences had negative impact on OHRQoL of preschoolers and families, and it is not moderated by parents' resilience.

Interest in oral health education through digital technologies: a cross-sectional study.

The aim of this study was to evaluate the interest of parents and caregivers of children and adolescents in receiving oral health education through digital technologies. A cross-sectional study was carried out with 150 parents and caregivers who provided sociodemographic data and answered questions about access to and interest in receiving oral health information through digital technologies. Descriptive and bivariate analyses were performed (P < 0.05). The majority of respondents (74.7%) were female. Most participants had access to the internet (91.3%) and expressed interest (88.0%) in receiving information on oral health through digital messages. Their preferred mode of communication was WhatsApp (73.0%), and they believed that messages about oral health could lead to improved daily oral care at home (95.9%). Women reported searching for health information on the internet more often than men (P = 0.004). Parents and caregivers of children and adolescents expressed interest in receiving information via digital technologies, suggesting that these tools can facilitate education and promote improved oral health.

Effects of lip bumper therapy on the mandibular arch dimensions of children and adolescents: A systematic review.

INTRODUCTION: The aim of this systematic review was to identify, evaluate, and provide a synthesis of the available literature on the effects of lip bumper (LB) therapy on the mandibular dental arch of children and adolescents. METHODS: MEDLINE, Scopus, Web of Science, Cochrane Library, and Lilacs were systematically searched without restrictions up to May 2019. Risk-of-bias assessment was performed using Cochrane's tool for randomized controlled trials (RCTs) and the Risk of Bias in Nonrandomized Studies of Interventions tool for non-RCTs. The Grading of Recommendations, Assessment, Development and Evaluation tool was used to assess the quality of the evidence. RESULTS: After examination of the full texts, 6 studies were included. One RCT presented unclear risk of bias, and 5 non-RCTs presented serious to moderate risk of bias. LB therapy resulted in a buccal inclination of the incisors, distalization of the permanent first molars, and distal inclination of the permanent first molars, which increased perimeter and arch length. An increase in the arch width with greater gain in the interpremolar and/or deciduous molar distance and less gain in intercanine and intermolar distances was also reported. LB therapy increased the risk of second molar impaction with inclination >30° and the risk of ectopic eruption when treatment time was >2 years. The level of the evidence was graded as very low for variable arch length and second molar eruption disturbances. All other outcomes were graded as having low level of evidence. CONCLUSIONS: Owing to the low level of certainty identified, the conclusions should be considered cautiously. Increase in arch perimeter and width was attributed to the proclination of the incisors, buccalization of the deciduous molar and premolar areas, and distal inclination of the molars. However, there was an increased chance of impaction and ectopic eruption of permanent second molar after treatment with LB.

Bone fenestration repair with leukocyte-platelet-rich fibrin after placement of implants in the anterior maxilla: a case report.

Few reports have been published to date on the management of bone fenestration in the anterior maxilla using leukocyte-platelet-rich fibrin (L-PRF) with deproteinized bovine bone mineral allograft (DBBMA). This case report demonstrates the use of L-PRF associated with DBBMA to repair a bone fenestration after the placement of 2 implants in the anterior maxilla. Placement of 2 osseointegrated implants was planned to replace the missing maxillary central incisors of a patient with bone loss in the buccal region. Reverse treatment planning predicted the fenestration of the buccal cortical plate and exposure of the implants. The implants were placed, and fenestration of the buccal cortical bone around the body of the implants occurred as expected. A mixture of L-PRF and DBBMA, mediated by injectable platelet-rich fibrin (a combination sometimes referred to as sticky bone), was positioned to cover the defect. Cone beam computed tomography 6 months after the intervention showed complete coverage of the fenestration with newly formed bone tissue. The use of L-PRF associated with DBBMA efficiently covered the fenestration and promoted new bone formation.

What are the effects of verbal and written information on pain perception in orthodontic patients?

Design Randomised controlled trial.Study population Sixty patients aged 10-18 years requiring fixed orthodontic treatment were randomly allocated to the study or control group. Anxiety levels and somatosensory amplification were evaluated. All patients received general verbal instructions on orthodontic treatment (dietary habits, oral hygiene maintenance and pain). Patients in the study group also received written information (a take-home leaflet) on orthodontic pain characteristics and management. Patients, clinicians and statistician were blinded to the patient allocation.Outcome measure The primary outcome was the pain intensity and the secondary outcome was analgesic consumption.Data analysis Multilevel regression analysis of variance (ANOVA) for repeated measures with split plot design.Results Pain perception and analgesic consumption were significantly higher in the control group only during the first two days after appliance placement (P <0.05).Conclusions Combining verbal and written information diminished pain perception and analgesic consumption in orthodontic patients in the first days after appliance placement.

Implications for dental professionals when caring for paediatric patients.

This paper is a narrative review of relevant literature.

The top 100 most-cited papers in Paediatric Dentistry journals: A bibliometric analysis.

BACKGROUND: The most-cited papers help to better understand important characteristics of this specific science field. OBJECTIVE: To analyse the 100 most-cited papers in the field of Paediatric Dentistry. DESIGN: A search of the most-cited papers in Paediatric Dentistry journals was performed using journals included in the category of 'Dentistry, Oral Surgery & Medicine' in the Thompson Reuters Web of Science citation indexing database up to December 2018. Two researchers performed the data extraction, which included: number of citations, title, authors, country, year, journals, study design, and thematic area. RESULTS: The number of citations of each paper included in the top 100 most-cited ranged from 42 to 182 (mean: 64.51). Seven papers were cited more than 100 times. Most of the papers were published in the International Journal of Paediatric Dentistry (36%), between 2006 and 2015 (55%), with a cross-sectional design (39%). Twenty-six authors participated in two or more papers. The countries with the highest number of most-cited papers were the United States (25%), Australia (11%), and Brazil (9%). Cariology was the most studied thematic area. CONCLUSION: The evaluation of the top 100 most-cited papers in Paediatric Dentistry journals allowed for a better understanding of the world scenario regarding this research field.

Zygomaticofacial, Zygomaticoorbital, and Zygomaticotemporal Foramina.

This study aimed to assess the anatomical and morphometric characteristics of the main zygomaticofacial (ZFF), zygomaticoorbital (ZOF), and zygomaticotemporal (ZTF) foramina in Brazilian dry skulls. 61, 69, and 42 skulls for ZFF, ZOF, and ZTF were evaluated by a single calibrated examiner for format, transverse and vertical diameters, and distances from the foramina to anatomical landmarks. Paired t test, Wilcoxon test, Pearson and Spearman correlations were used. Circular outline was the predominant format for ZFF and ZTF, while oval format was the most frequent for ZOF. Median distances from ZFF to frontozygomatic and zygomaticomaxillary sutures were higher on right and left sides of the skulls, respectively (P < 0.005). Mean ZOF transverse diameter was significantly higher on the right sides of the skulls and presented positive correlation between sides (P < 0.05). No differences were observed for mean vertical diameter and distance from the ZOF to the inferolateral angle of the orbit (P > 0.05). No significant difference was found for distance from the ZTF to zygomatic arch between sides (P > 0.05), although there was a positive correlation (P < 0.05). Significant differences were found when analyzing the anatomical and morphometric aspects of ZFF, ZOF, and ZTF.

Analysis of Anatomical Characteristics and Morphometric Aspects of Infraorbital and Accessory Infraorbital Foramina.

OBJECTIVE: This study aimed to perform a morphological and morphometric study of the characteristics of the infraorbital foramen (IOF) and accessory infraorbital foramen (AIOF) in Brazilian skulls. METHODS: A sample calculation determined a total of 94 human skulls to be evaluated by a trained examiner for number, shape, diameters, and location of IOF in relation to anatomical landmarks. Number, size, shape, diameters, location, orientation, position, and distances in relation to anatomical landmarks were evaluated for the AIOF. Descriptive analysis, paired t test, Wilcoxon test, Pearson and Spearman correlations were used. RESULTS: A total of 188 IOFs and 48 AIOFs were found. Circular outline was the predominant shape for both IOFs and AIOFs. Infraorbital foramens presented in left sides had a significantly greater transverse diameter and distance from medial margin of the orbit when compared with IOFs located on the right sides (P <0.001). Accessory infraorbital foramens were most frequently found on the left sides of the skulls and had a superomedial position in relation to the IOFs. Accessory infraorbital foramens located on right sides had a significantly greater distance to anterior nasal spine when compared with AIOFs located on the left sides (P <0.001). CONCLUSIONS: The results of this solid methodology-based study can help guide surgeons in accurately locating the IOF and AIOF, and consequently, their neurovascular bundles to perform safe procedures during maxillofacial interventions.

Evaluation of carbon nanotubes functionalized with sodium hyaluronate in the inflammatory processes for oral regenerative medicine applications.

OBJECTIVES: The objectives of this study were to assess the effects of hyaluronic acid (HY), multi-walled carbon nanotubes (MWCNT), and MWCNT functionalized with HY (HY-MWCNT) on the resolution of neutrophilic inflammation in the pleural cavity of LPS-challenged mice and to assess the influence of these materials in the inflammatory process of bone repair of tooth sockets of rats. MATERIALS AND METHODS: C57Bl/6 mice were intra-pleurally injected with HY, MWCNT, HY-MWCNT, phosphate-buffered saline (PBS), or LPS. The animals were euthanized after 8 and 24 h, and cells were harvested for total and differential cell counting. The tooth sockets of Wistar rats were filled with HY, MWCNT, HY-MWCNT, or blood clot (control). After 1, 3, and 7 days, histological and morphometric analyses evaluated the number of cell nuclei and blood vessels, and bone trabeculae formation in the sockets. Myeloperoxidase (MPO) activity quantified neutrophil accumulation in the sockets. RESULTS: HY, MWCNT, and HY-MWCNT increased neutrophilic recruitment at 8 h and reduced the inflammatory process at 24 h in the pleural cavity. Histological and morphometric analyses and MPO activity showed no significant differences in the recruitment of inflammatory cells in the tooth sockets. HY increased the number of blood vessels, and HY and HY-MWCNT increased bone trabeculae formation at 7 days of tooth extraction. CONCLUSIONS: HY, MWCNT, and HY-MWCNT resolved the neutrophilic inflammation in the pleural cavity of the mice. However, these materials did not modulate the inflammatory process in the early stages of bone repair of the tooth sockets, thereby excluding this action as a possible mechanism by which these biomaterials accelerate bone repair. CLINICAL RELEVANCE: HY-MWCNT is capable of accelerating bone repair/regeneration without affecting the inflammatory phase during the bone healing process.