Detalhe da pesquisa
1.
Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene.
J Appl Toxicol
; 44(3): 333-343, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-37699698
2.
Application of a skin and liver Chip2 microphysiological model to investigate the route-dependent toxicokinetics and toxicodynamics of consumer-relevant doses of genistein.
J Appl Toxicol
; 44(2): 287-300, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37700462
3.
Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research.
PLoS Comput Biol
; 18(10): e1010587, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36260620
4.
Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Annu Rev Pharmacol Toxicol
; 58: 65-82, 2018 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29029591
5.
Demonstration of the first-pass metabolism in the skin of the hair dye, 4-amino-2-hydroxytoluene, using the Chip2 skin-liver microphysiological model.
J Appl Toxicol
; 41(10): 1553-1567, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33594739
6.
Validation of Bioreactor and Human-on-a-Chip Devices for Chemical Safety Assessment.
Adv Exp Med Biol
; 856: 299-316, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27671728
7.
Development and analysis of alpha 1-antitrypsin neoglycoproteins: the impact of additional N-glycosylation sites on serum half-life.
Mol Pharm
; 10(7): 2616-29, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23668542
8.
Fluorescent optical fiber sensors for cell viability monitoring.
Analyst
; 138(14): 4066-9, 2013 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23662302
9.
A rodent thyroid-liver chip to capture thyroid toxicity on organ function level.
ALTEX
; 40(1): 83-102, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-35791291
10.
A microfluidic thyroid-liver platform to assess chemical safety in humans.
ALTEX
; 40(1): 61-82, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-35536601
11.
Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions.
Front Pharmacol
; 14: 1076254, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36843954
12.
Trends in cell culture technology.
Adv Exp Med Biol
; 745: 26-46, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22437811
13.
'Human-on-a-chip' developments: a translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man?
Altern Lab Anim
; 40(5): 235-57, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23215661
14.
Proof-of-Concept Organ-on-Chip Study: Topical Cinnamaldehyde Exposure of Reconstructed Human Skin with Integrated Neopapillae Cultured under Dynamic Flow.
Pharmaceutics
; 14(8)2022 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35893784
15.
A Human Stem Cell-Derived Brain-Liver Chip for Assessing Blood-Brain-Barrier Permeation of Pharmaceutical Drugs.
Cells
; 11(20)2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36291161
16.
Emerging technologies and their impact on regulatory science.
Exp Biol Med (Maywood)
; 247(1): 1-75, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34783606
17.
N-glycosylation and biological activity of recombinant human alpha1-antitrypsin expressed in a novel human neuronal cell line.
Biotechnol Bioeng
; 108(9): 2118-28, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21495009
18.
Supporting dataset of two integration-free induced pluripotent stem cell lines from related human donors.
Data Brief
; 37: 107140, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34136596
19.
Generation of two additional integration-free iPSC lines from related human donors.
Stem Cell Res
; 53: 102327, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33901815
20.
An Individual Patient's "Body" on Chips-How Organismoid Theory Can Translate Into Your Personal Precision Therapy Approach.
Front Med (Lausanne)
; 8: 728866, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34589503