Detalhe da pesquisa
1.
Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase.
Proc Natl Acad Sci U S A
; 121(21): e2403685121, 2024 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38743625
2.
Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis.
J Immunol
; 198(7): 2735-2746, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28242647
3.
Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Biochemistry
; 57(47): 6604-6614, 2018 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30365304
4.
LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase.
bioRxiv
; 2023 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37904985
5.
Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy.
Cancer Metab
; 8: 1, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31908776
6.
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.
Cell Rep
; 27(7): 1991-2001.e5, 2019 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31091439
7.
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis.
Nat Commun
; 9(1): 4945, 2018 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30470748
8.
mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response.
Mol Cell Biol
; 38(4)2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29180510
9.
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.
Cancer Cell
; 32(1): 71-87.e7, 2017 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28697344
10.
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.
Cancer Cell
; 32(3): 392, 2017 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28898700