Detalhe da pesquisa
1.
Bacillus subtilis as a host for natural product discovery and engineering of biosynthetic gene clusters.
Nat Prod Rep
; 2024 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38465694
2.
Exploring the selectivity of cytochrome P450 for enhanced novel anticancer agent synthesis.
Faraday Discuss
; 2024 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38855920
3.
Polyketide Synthase-Mediated O-Methyloxime Formation in the Biosynthesis of the Oximidine Anticancer Agents.
Angew Chem Int Ed Engl
; 62(34): e202304476, 2023 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37218580
4.
Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis.
Nat Prod Rep
; 38(10): 1910-1937, 2021 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34676836
5.
Genomics-Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism.
Angew Chem Int Ed Engl
; 59(51): 23145-23153, 2020 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32918852
6.
The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI.
Angew Chem Int Ed Engl
; 59(26): 10549-10556, 2020 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32208550
7.
Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis.
J Am Chem Soc
; 139(23): 7974-7981, 2017 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28528545
8.
The zeamine antibiotics affect the integrity of bacterial membranes.
Appl Environ Microbiol
; 81(3): 1139-46, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25452285
9.
A conserved motif flags acyl carrier proteins for ß-branching in polyketide synthesis.
Nat Chem Biol
; 9(11): 685-692, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24056399
10.
Combinatorial optimization of gene expression through recombinase-mediated promoter and terminator shuffling in yeast.
Nat Commun
; 15(1): 1112, 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38326309
11.
Artificial intelligence for natural product drug discovery.
Nat Rev Drug Discov
; 22(11): 895-916, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37697042
12.
Minimum Information about a Biosynthetic Gene cluster.
Nat Chem Biol
; 11(9): 625-31, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26284661
13.
Total Synthesis of Kalimantacin A.
Org Lett
; 22(16): 6349-6353, 2020 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32806153
14.
A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis.
Nat Chem
; 11(10): 906-912, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31548673
15.
An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles 'fungal' icosalide antibiotics.
Chem Sci
; 10(21): 5489-5494, 2019 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31293732
16.
Pentamycin Biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-Catalyzed Installation of the C-14 Hydroxyl Group.
ACS Chem Biol
; 14(6): 1305-1309, 2019 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31095370
17.
Structural basis for chain release from the enacyloxin polyketide synthase.
Nat Chem
; 11(10): 913-923, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31548674
18.
Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics.
Chem Sci
; 8(9): 6196-6201, 2017 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28989652
19.
Systematic analysis of the kalimantacin assembly line NRPS module using an adapted targeted mutagenesis approach.
Microbiologyopen
; 5(2): 279-86, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26666990
20.
A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics.
Chem Sci
; 6(2): 923-929, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29560178