Detalhe da pesquisa
1.
Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).
Molecules
; 21(8)2016 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27527129
2.
Pressure adaptation is linked to thermal adaptation in salt-saturated marine habitats.
Environ Microbiol
; 17(2): 332-45, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25330254
3.
Identification and characterization of carboxyl esterases of gill chamber-associated microbiota in the deep-sea shrimp Rimicaris exoculata by using functional metagenomics.
Appl Environ Microbiol
; 81(6): 2125-36, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25595762
4.
Molecular adaptation of Lactobacillus plantarum WCFS1 to gallic acid revealed by genome-scale transcriptomic signature and physiological analysis.
Microb Cell Fact
; 14: 160, 2015 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26453568
5.
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
Bioorg Med Chem
; 22(18): 5078-90, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25047938
6.
PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin.
J Med Chem
; 67(4): 2619-2630, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38294341
7.
A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.
Org Biomol Chem
; 11(18): 3046-56, 2013 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23532250
8.
Enzyme adaptation to habitat thermal legacy shapes the thermal plasticity of marine microbiomes.
Nat Commun
; 14(1): 1045, 2023 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36828822
9.
Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency.
Eur J Med Chem
; 259: 115668, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37490800
10.
Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site.
Biochemistry
; 51(1): 329-41, 2012 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22148836
11.
Multiple keys for a single lock: the unusual structural plasticity of the nucleotidyltransferase (4')/kanamycin complex.
Chemistry
; 18(10): 2875-89, 2012 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22298309
12.
Modulation of microtubule interprotofilament interactions by modified taxanes.
Biophys J
; 101(12): 2970-80, 2011 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22208196
13.
Harnessing DNA for nanothermometry.
J Biophotonics
; 14(2): e202000341, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33128802
14.
Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin.
Chemistry
; 15(39): 10144-57, 2009 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19697384
15.
Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel.
Chem Biol
; 15(6): 573-85, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18559268
16.
Synthesis and biological activities of high affinity taxane-based fluorescent probes.
Bioorg Med Chem Lett
; 19(3): 751-4, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19128972
17.
Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.
J Med Chem
; 50(12): 2865-74, 2007 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17497841
18.
Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin.
Cell Chem Biol
; 24(6): 737-750.e6, 2017 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28579361
19.
New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.
ACS Chem Biol
; 8(9): 2084-94, 2013 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23859655
20.
Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,ß-heterodimers and microtubules.
Chem Biol
; 19(6): 686-98, 2012 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22726683