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Int Arch Occup Environ Health ; 83(5): 483-95, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20306073

RESUMO

PURPOSE: To evaluate the effectiveness of personal protective measures in a dismantling plant for chemical weapons from World War I of the Belgian Defence. METHODS: Seventeen NIOSH level B-equipped plant workers exposed to arsenic trichloride (AsCl(3)) in combination with phosgene or hydrogen cyanide (HCN) were compared to 24 NIOSH level C-protected field workers occasionally exposed to genotoxic chemicals (including AsCl(3)-phosgene/HCN) when collecting chemical ammunition, and 19 matched referents. Chromosomal aberrations (CA), micronuclei (MNCB and MNMC), sister chromatid exchanges (SCE) and high frequency cells (HFC) were analysed in peripheral blood lymphocytes. Urinary arsenic levels and genetic polymorphisms in major DNA repair enzymes (hOGG1(326), XRCC1(399), XRCC3(241)) were also assessed. RESULTS: SCE and HFC levels were significantly higher in plant-exposed versus referent subjects, but MNCB and MNMC were not different. MNCB, SCE and HFC levels were significantly higher and MNMC levels significantly lower in field-exposed workers versus referents. AsCl(3) exposure was not correlated with genotoxicity biomarkers. CONCLUSIONS: Protective measures for plant-exposed workers appear adequate, but protection for field-exposed individuals could be improved.


Assuntos
Substâncias para a Guerra Química/intoxicação , Aberrações Cromossômicas/induzido quimicamente , Mutagênicos/toxicidade , Exposição Ocupacional/efeitos adversos , I Guerra Mundial , Fatores Etários , Arsênio/urina , Arsenicais , Cloretos/intoxicação , Comportamentos Relacionados com a Saúde , Humanos , Cianeto de Hidrogênio/intoxicação , Linfócitos/química , Masculino , Micronúcleos com Defeito Cromossômico/induzido quimicamente , Fosgênio/intoxicação , Equipamentos de Proteção , Vigilância de Evento Sentinela , Troca de Cromátide Irmã
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