Tripled yield in direct-drive laser fusion through statistical modelling.

Focusing laser light onto a very small target can produce the conditions for laboratory-scale nuclear fusion of hydrogen isotopes. The lack of accurate predictive models, which are essential for the design of high-performance laser-fusion experiments, is a major obstacle to achieving thermonuclear ignition. Here we report a statistical approach that was used to design and quantitatively predict the results of implosions of solid deuterium-tritium targets carried out with the 30-kilojoule OMEGA laser system, leading to tripling of the fusion yield to its highest value so far for direct-drive laser fusion. When scaled to the laser energies of the National Ignition Facility (1.9 megajoules), these targets are predicted to produce a fusion energy output of about 500 kilojoules-several times larger than the fusion yields currently achieved at that facility. This approach could guide the exploration of the vast parameter space of thermonuclear ignition conditions and enhance our understanding of laser-fusion physics.

Anomalous Absorption by the Two-Plasmon Decay Instability.

Radiation-hydrodynamic simulations of directly driven fusion experiments at the Omega Laser Facility predict absorption accurately when targets are driven at low overlapped laser intensity. Discrepancies appear at increased intensity, however, with higher-than-expected laser absorption on target. Strong correlations with signatures of the two-plasmon decay (TPD) instability-including half-harmonic and hard-x-ray emission-indicate that TPD is responsible for this anomalous absorption. Scattered light data suggest that up to ≈30% of the laser power reaching quarter-critical density can be absorbed locally when the TPD threshold is exceeded. A scaling of absorption versus TPD threshold parameter was empirically determined and validated using the laser-plasma simulation environment code.

Plasma Density Measurements of the Inner Shell Release.

The material release on the side opposite to the laser drive of a CH shell was probed at conditions relevant to inertial confinement fusion. The release was found to expand further with a longer scale length than that predicted by radiation-hydrodynamic simulations. The simulations show that a relaxation of the back side of the shell consistent with measurements explains the experimentally observed reduction in inertial confinement fusion implosion performance-specifically, reduced areal density at peak compression.

The meio- to macrozoobenthos ratio in a lake benthic community: Dynamic aspect.

Multiyear data (2002-2015) on the biomasses of meio- and macrozoobenthic communities have been studied at different depths of a small lake in northern Karelia. A trend towards anti-phase changes in meio- and macrobenthic biomasses was observed and, as a consequence, the ratio between these components varied significantly in different years. Thus, inter-annual dynamics should be taken into account in analysis of hydrobiological data.

Multiple beam two-plasmon decay: linear threshold to nonlinear saturation in three dimensions.

The linear stability of multiple coherent laser beams with respect to two-plasmon-decay instability in an inhomogeneous plasma in three dimensions has been determined. Cooperation between beams leads to absolute instability of long-wavelength decays, while shorter-wavelength shared waves are shown to saturate convectively. The multibeam, in its absolutely unstable form, has the lowest threshold for most cases considered. Nonlinear calculations using a three-dimensional extended Zakharov model show that Langmuir turbulence created by the absolute instability modifies the convective saturation of the shorter-wavelength modes, which are seen to dominate at late times.

Ultrasound-assisted preparation of PdCo bimetallic nanoparticles loaded on beta zeolite for efficient catalytic hydrogen production from dodecahydro-N-ethylcarbazole.

Research and development of high-performance catalysts is a key technology to realize hydrogen energy storage and transportation based on liquid organic hydrogen carriers. Co/beta was prepared using beta zeolite as a carrier via an electrostatic adsorption (ESA)-chemical reduction method, and it was used as the template and reducing agent to prepare bimetallic catalysts via an ultrasonic assisted galvanic replacement process (UGR). The fabricated PdCo/beta were characterized by TEM, XPS, FT-IR, XRD, H2-TPR, and H2-TPD. It was shown that the ultrafine PdCo nanoparticles (NPs) are evenly distributed on the surface of the beta zeolite. There is electron transfer between metal NPs and strong-metal-support-interaction (SMSI), which results in highly efficient catalytic dodecahydro-N-ethylcarbazole (12H-NEC) dehydrogenation performance of PdCo bimetallic catalysts. The dehydrogenation efficiency reached 100 % in 4 h at 180 °C and 95.3 % in 6 h at 160 °C. The TOF of 146.22 min-1 is 7 times that of Pd/beta. The apparent activation energy of the reaction is 66.6 kJ/mol, which is much lower than that of Pd/beta. Under the action of ultrasonic waves, the galvanic replacement reaction is accelerated, and the intermetal and metal-carrier interactions are enhanced, which improves the catalytic reaction performance.

Generating energetic electrons through staged acceleration in the two-plasmon-decay instability in inertial confinement fusion.

A new hot-electron generation mechanism in two-plasmon-decay instabilities is described based on a series of 2D, long-term (~10 ps) particle-in-cell and fluid simulations under parameters relevant to inertial confinement fusion. The simulations show that significant laser absorption and hot-electron generation occur in the nonlinear stage. The hot electrons are stage accelerated from the low-density region to the high-density region. New modes with small phase velocities develop in the low-density region in the nonlinear stage and form the first stage for electron acceleration. Electron-ion collisions are shown to significantly reduce the efficiency of this acceleration mechanism.

Experimental validation of the two-plasmon-decay common-wave process.

The energy in hot electrons produced by the two plasmon decay instability, in planar targets, is measured to be the same when driven by one or two laser beams and significantly reduced with four for a constant overlapped intensity on the OMEGA EP. This is caused by multiple beams sharing the same common electron-plasma wave. A model, consistent with the experimental results, predicts that multiple laser beams can only drive a resonant common two plasmon decay electron-plasma wave in the region of wave numbers bisecting the beams. In this region, the gain is proportional to the overlapped laser beam intensity.

Ionization state and dielectric constant in cold rarefied hydrocarbon plasmas of inertial confinement fusion.

A combined approach to study cold rarefied matter is introduced that includes a semianalytical method based on the free-energy minimization and ab initio calculations based on the finite-temperature density-functional theory. The approach is used to calculate the ionization state of hydrocarbon (CH) under the shock-release conditions in inertial confinement fusion. The dielectric constant of CH is calculated using the Kubo-Greenwood formulation and contribution from atomic polarizabilities is found to be as important as the free-electron contribution. Using the ionization state and dielectric constant, the electron density profile in the rarefaction wave of the shock-release plasma is obtained.

Nonlinear transmission of laser light through coronal plasma due to self-induced incoherence.

The success of direct laser-driven inertial confinement fusion (ICF) relies critically on the efficient coupling of laser light to plasma. At ignition scale, the absolute stimulated Raman scattering (SRS) instability can severely inhibit this coupling by redirecting and strongly depleting laser light. This article describes a new dynamic saturation regime of the absolute SRS instability near one-quarter of the critical density. The saturation occurs when spatiotemporal ion-acoustic fluctuations in the plasma density detune the instability resonance. The dynamic saturation mitigates the strong depletion of laser light and enhances its transmission through the instability region, explaining the coupling of laser light to ICF targets at higher plasma densities.

Growth and saturation of convective modes of the two-plasmon decay instability in inertial confinement fusion.

Particle-in-cell (PIC) and fluid simulations of two-plasmon decay (TPD) instability under conditions relevant to inertial confinement fusion show the importance of convective modes. Growing at the lower density region, the convective modes can cause pump depletion and are energetically dominant in the nonlinear stage. The PIC simulations show that TPD saturates due to ion density fluctuations, which can turn off TPD by raising the instability threshold through mode coupling.

Optimizing electron-positron pair production on kilojoule-class high-intensity lasers for the purpose of pair-plasma creation.

Expressions for the yield of electron-positron pairs, their energy spectra, and production rates have been obtained in the interaction of multi-kJ pulses of high-intensity laser light interacting with solid targets. The Bethe-Heitler conversion of hard x-ray bremsstrahlung [D. A. Gryaznykh, Y. Z. Kandiev, and V. A. Lykov, JETP Lett. 67, 257 (1998); K. Nakashima and H. Takabe, Phys. Plasmas 9, 1505 (2002)] is shown to dominate over direct production (trident process) [E. P. Liang, S. C. Wilks, and M. Tabak, Phys. Rev. Lett. 81, 4887 (1998)]. The yields and production rates have been optimized as a function of incident laser intensity by the choice of target material and dimensions, indicating that up to 5 x 10 (11) pairs can be produced on the OMEGA EP laser system [L. J. Waxer, Opt. Photonics News 16, 30 (2005)]. The corresponding production rates are high enough to make possible the creation of a pair plasma.

Three-dimensional particle-in-cell modeling of parametric instabilities near the quarter-critical density in plasmas.

The nonlinear regime of laser-plasma interactions including both two-plasmon decay (TPD) and stimulated Raman scattering (SRS) instabilities has been studied in three-dimensional (3D) particle-in-cell simulations with parameters relevant to the inertial confinement fusion (ICF) experiments. SRS and TPD develop in the same region in plasmas, and the generation of fast electrons can be described accurately with only the full model including both SRS and TPD. The growth of instabilities in the linear stage is found to be in good agreement with analytical theories. In the saturation stage the low-frequency density perturbations driven by the daughter waves of the SRS side scattering can saturate the TPD and consequently inhibit the fast-electron generation. The fast-electron flux in 3D modeling is up to an order of magnitude smaller than previously reported in 2D TPD simulations, bringing it close to the results of ICF experiments.

Experimental platform for investigations of high-intensity laser plasma interactions in the magnetic field of a pulsed power generator.

An experimental platform for the studying of high-intensity laser plasma interactions in strong magnetic fields has been developed based on the 1 MA Zebra pulsed power generator coupled with the 50-TW Leopard laser. The Zebra generator produces 100-300 T longitudinal and transverse magnetic fields with different types of loads. The Leopard laser creates plasma at an intensity of 1019 W/cm2 in the magnetic field of coil loads. Focusing and targeting systems are integrated in the vacuum chamber of the pulsed power generator and protected from the plasma debris and strong mechanical shock. The first experiments with plasma at laser intensity >2 × 1018 W/cm2 demonstrated collimation of the laser produced plasma in the axial magnetic field strength >100 T.

Disruption of actin filaments increases the activity of sodium-conducting channels in human myeloid leukemia cells.

With the use of the patch clamp technique, the role of cytoskeleton in the regulation of ion channels in plasma membrane of leukemic K562 cells was examined. Single-channel measurements have indicated that disruption of actin filaments with cytochalasin D (CD) resulted in a considerable increase of the activity of non-voltage-gated sodium-permeable channels of 12 pS unitary conductance. Background activity of these channels was low; open probability (po) did not exceed 0.01-0.02. After CD, po grew at least 10-20 times. Cell-attached and whole-cell recordings showed that activation of sodium channels was elicited within 1-3 min after the addition of 10-20 micrograms/ml CD to the bath extracellular solution or in the presence of 5 micrograms/ml CD in the intracellular pipette solution. Preincubation of K562 cells with CD during 1 h also increased drastically the activity of 12 pS sodium channels. Whole-cell measurements confirmed that CD-activated channels were permeable to monovalent cations (preferentially to Na+ and Li+), but not to bivalent cations (Ca2+, Ba2+). Colchicine (1 microM), which affect microtubules, did not alter background channel activity. Our data indicate that actin filaments organization plays an important role in the regulation of sodium-permeable channels which may participate in providing passive Na+ influx in red blood cells.

Classification of PDZ domains.

A diverse family of PDZ domains has been identified, but the rules that govern their ligand specificity are not clear. Here we propose a novel classification of PDZ domains based on the nature of amino acids in the two critical positions in the PDZ domain fold. Using these principles, we classified PDZ domains present in the SMART database. Using yeast two-hybrid, in vitro pull-down and plasmon surface resonance assays, we demonstrated that in agreement with their position in the proposed classification the Mint1-1, hINADL-5, and PAR6 PDZ domains display similar dual ligand specificity. The proposed classification helps to organize PDZ domain containing proteins.

Ca-dependent regulation of Na+-selective channels via actin cytoskeleton modification in leukemia cells.

With the use of the patch-clamp technique, physiological mechanisms of Na+ channel regulation involving submembranous actin rearrangements were examined in human myeloid leukemia K562 cells. We found that the actin-severing protein gelsolin applied to cytoplasmic surface of membrane fragments at a high level of [Ca2+]i (1 microM) increased drastically the activity of Na-selective channels of 12 pS unitary conductance. In the experiments on intact cells, the elevation of [Ca2+]i using the ionophore 4Br-A23187 also resulted in Na+ channel activation. Addition of actin to the cytoplasmic surface of membrane patches reduced this activity to background level, likely due to actin polymerization. Our data imply that Ca-dependent modulations of the actin cytoskeleton may represent one of the general mechanisms of channel regulation and cell signalling.

Comparative efficacy and safety of advanced drug therapy in children with juvenile rheumatoid arthritis.

Results from three randomized placebo-controlled trials were combined in a meta-analysis to compare the clinical utility of four advanced drug therapy agents used to treat juvenile rheumatoid arthritis (JRA): D-penicillamine (10 mg/kg/d), hydroxychloroquine (6 mg/kg/d), auranofin (oral gold, 0.15 to 0.20 mg/kg/d), and two low dose levels of methotrexate [5MTX, 5 mg/M2/wk; 10MTX, 10 mg/M2/wk]. A total of 520 children with JRA were enrolled into these trials. Only 10MTX resulted in significantly greater improvement than placebo in variables that assess effectiveness: physician's global assessment, a composite index, and erythrocyte sedimentation rate. Treatment effect sizes were the largest in the 10MTX group for all articular disease indices. The short-term safety profiles were similar across all treatment groups. It is concluded that the current trend among pediatric rheumatologists to use oral methotrexate as the first advanced drug therapy in JRA is appropriate and that the minimum effective dose is 10 mg/M2/wk.

Resonant instability of laser filaments in a plasma

The stability of nonlinear laser light filaments in a homogeneous isothermal plasma with respect to coupled electromagnetic and density perturbations is examined. In addition to the previously known modulational instability of a trapped electromagnetic mode, a new fast growing resonant instability is found. It corresponds to the growth of an excited eigenmode in the waveguide formed by the filament density depletion, the associated density response being supersonic and transversally localized. The evolution of the instability is illustrated by numerical simulations in two and three spatial dimensions.

Enhanced forward scattering in the case of two crossed laser beams interacting with a plasma

The nonlinear enhancement of large-angle forward scattering of two identical laser beams propagating in a preformed plasma has been observed experimentally. The spectral analysis of the forward-scattered light shows two components, one which is unshifted with respect to the initial laser light frequency, and the other which is redshifted by a few angstroms. The redshifted component is found to be strongly enhanced in the case of crossed beam interaction in comparison with that of one beam illumination. Two-dimensional numerical simulations show that this enhancement is due to large-angle forward stimulated Brillouin scattering in which each beam serves as seed for the forward scattering of the other.