Detalhe da pesquisa
1.
Development of a quantitative semi-mechanistic model of Alzheimer's disease based on the amyloid/tau/neurodegeneration framework (the Q-ATN model).
Alzheimers Dement
; 19(6): 2287-2297, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36454709
2.
Ocular Half-Life of Intravitreal Biologics in Humans and Other Species: Meta-Analysis and Model-Based Prediction.
Mol Pharm
; 17(2): 695-709, 2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31876425
3.
Theoretical Insights into the Retinal Dynamics of Vascular Endothelial Growth Factor in Patients Treated with Ranibizumab, Based on an Ocular Pharmacokinetic/Pharmacodynamic Model.
Mol Pharm
; 15(7): 2770-2784, 2018 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29734810
4.
An in silico model of retinal cholesterol dynamics (RCD model): insights into the pathophysiology of dry AMD.
J Lipid Res
; 58(7): 1325-1337, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28442497
5.
Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model.
Mol Pharm
; 14(8): 2690-2696, 2017 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28631484
6.
Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach.
J Lipid Res
; 57(1): 46-55, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26522778
7.
A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular Vascular Endothelial Growth Factor Levels by Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration.
Mol Pharm
; 13(9): 2941-50, 2016 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26726925
8.
An in-silico model of lipoprotein metabolism and kinetics for the evaluation of targets and biomarkers in the reverse cholesterol transport pathway.
PLoS Comput Biol
; 10(3): e1003509, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24625468
10.
Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels: A Randomized Clinical Trial.
JAMA
; 314(6): 570-81, 2015 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26262795
11.
Adverse events associated with testosterone administration.
N Engl J Med
; 363(2): 109-22, 2010 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20592293
12.
A comparison of the theoretical relationship between HDL size and the ratio of HDL cholesterol to apolipoprotein A-I with experimental results from the Women's Health Study.
Clin Chem
; 59(6): 949-58, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23426429
13.
A semi-mechanistic model of the relationship between average glucose and HbA1c in healthy and diabetic subjects.
J Pharmacokinet Pharmacodyn
; 40(2): 129-42, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23307170
14.
Effect of testosterone replacement on response to sildenafil citrate in men with erectile dysfunction: a parallel, randomized trial.
Ann Intern Med
; 157(10): 681-91, 2012 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23165659
15.
Effect of testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial.
JAMA
; 307(9): 931-9, 2012 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22396515
16.
In silico exploration of amyloid-related imaging abnormalities in the gantenerumab open-label extension trials using a semi-mechanistic model.
Alzheimers Dement (N Y)
; 8(1): e12306, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35676943
17.
A novel spreadsheet method for calculating the free serum concentrations of testosterone, dihydrotestosterone, estradiol, estrone and cortisol: with illustrative examples from male and female populations.
Steroids
; 74(6): 512-9, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19321131
18.
A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal women.
J Clin Endocrinol Metab
; 93(5): 1702-10, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18303079
19.
A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women.
Menopause
; 14(6): 985-94, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17507833
20.
Differences in the apparent metabolic clearance rate of testosterone in young and older men with gonadotropin suppression receiving graded doses of testosterone.
J Clin Endocrinol Metab
; 91(11): 4669-75, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16912120