Detalhe da pesquisa
1.
Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo.
J Virol
; 88(17): 10228-43, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24965445
2.
KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models.
BMC Cancer
; 15: 941, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26620414
3.
Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.
Blood
; 120(23): 4621-34, 2012 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23034282
4.
Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines.
BMC Vet Res
; 10: 160, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25022346
5.
KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.
Br J Haematol
; 161(1): 117-27, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23373539
6.
Selective inhibitors of nuclear export for the treatment of non-Hodgkin's lymphomas.
Haematologica
; 98(7): 1098-106, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23403316
7.
Erratum to: KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models.
BMC Cancer
; 16: 8, 2016 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26753765
8.
Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102.
Cancer Res
; 67(15): 7358-67, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17671206
9.
Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer.
Clin Cancer Res
; 23(6): 1552-1563, 2017 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27649553
10.
Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10-Dependent Apoptosis by Carfilzomib and Selinexor.
Mol Cancer Ther
; 15(1): 60-71, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26637366
11.
First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors.
J Clin Oncol
; 34(34): 4142-4150, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26926685
12.
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.
Neuro Oncol
; 17(5): 697-707, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25366336
13.
Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Nat Neurosci
; 18(4): 511-20, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25706475
14.
XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.
Clin Cancer Res
; 21(14): 3286-97, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25878333
15.
Nucleo-cytoplasmic transport as a therapeutic target of cancer.
J Hematol Oncol
; 7: 85, 2014 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25476752
16.
XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer.
Mol Cancer Ther
; 13(3): 675-86, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24431073
17.
XPO1/CRM1-selective inhibitors of nuclear export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa).
J Hematol Oncol
; 7: 46, 2014 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25284315
18.
Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study.
PLoS One
; 9(2): e87585, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24503695
19.
Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS.
ACS Med Chem Lett
; 2(2): 97-101, 2011 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900286
20.
Intraocular injection of an aptamer that binds PDGF-B: a potential treatment for proliferative retinopathies.
J Cell Physiol
; 207(2): 407-12, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16419035