1.
Bioorg Med Chem Lett
; 24(4): 1239-42, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23916257
RESUMO
SAR study of 5-aminooctahydrocyclopentapyrrole-3a-carboxamide scaffold led to identification of several CCR2 antagonists with potent activity in both binding and functional assays. Their cardiovascular safety and pharmacokinetic properties were also evaluated.