Detalhe da pesquisa
1.
Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity.
J Immunol
; 198(3): 1308-1319, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28003376
2.
Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).
Bioorg Med Chem Lett
; 26(10): 2470-2474, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27055941
3.
Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity.
J Pharmacol Exp Ther
; 354(2): 152-65, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26015463
4.
Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.
Bioorg Med Chem Lett
; 24(9): 2206-11, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24685542
5.
An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.
J Immunol
; 184(7): 3917-26, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20190141
6.
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 21(15): 4633-7, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21705217
7.
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.
Bioorg Med Chem Lett
; 21(1): 383-6, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21087862
8.
Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066).
Bioorg Med Chem Lett
; 21(23): 7006-12, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22018461
9.
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
J Med Chem
; 64(1): 677-694, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33370104
10.
Bicyclic Ligand-Biased Agonists of S1P1: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles.
J Med Chem
; 64(3): 1454-1480, 2021 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33492963
11.
5-amino-pyrazoles as potent and selective p38α inhibitors.
Bioorg Med Chem Lett
; 20(23): 6886-9, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21035336
12.
Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles.
ACS Med Chem Lett
; 11(9): 1766-1772, 2020 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32944145
13.
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.
ACS Med Chem Lett
; 11(11): 2195-2203, 2020 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33214829
14.
Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.
J Pharmacol Exp Ther
; 331(2): 349-60, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19652024
15.
Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.
Bioorg Med Chem Lett
; 19(10): 2646-9, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19376699
16.
Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
J Med Chem
; 62(20): 8953-8972, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31314518
17.
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
J Med Chem
; 62(20): 8973-8995, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31318208
18.
Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis.
ACS Med Chem Lett
; 10(3): 306-311, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891131
19.
Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.
ACS Med Chem Lett
; 10(3): 383-388, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891145
20.
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.
Sci Transl Med
; 11(502)2019 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31341059