RESUMO
This paper reports a case of carcinoma arising in a benign mixed tumor of lacrimal gland following multiple recurrences. The patient had eight recurrences of the benign lesion and after 32 years developed an adenocarcinoma associated with recurrent nodules of still recognizable benign mixed tumor. The literature on malignant mixed tumors of the lacrimal gland is reviewed noting the confusion in diagnostic terminology in early reports. Our patient illustrates the resemblance between malignant mixed tumor (carcinoma arising in pleomorphic adenoma) of lacrimal and salivary gland both clinically and pathologically.
Assuntos
Doenças do Aparelho Lacrimal/patologia , Neoplasias Embrionárias de Células Germinativas/patologia , Adolescente , Adulto , Feminino , Humanos , Doenças do Aparelho Lacrimal/cirurgia , Recidiva Local de Neoplasia , Neoplasias Embrionárias de Células Germinativas/cirurgiaRESUMO
The radioactive phosphorus uptake of 30 samples fron nine uveal melanomas was determined by liquid scintillation counting. These in vitro measurements correlated positively with clinical (in vivo) 32P values and with the number of mitotic figures and percentage of epithelioid cells (PEC) within the specimens. Three possible explanations were found for the failure of previous workers to demonstrate a correlation between cell type and clinical 32P. (1) Cell type, using Callender's classification, provides only a crude estimate of the PEC within a tumor; in particular, tumors of mixed cell type can vary widely in epithelioid cell content. (2) The rate of 32P absorption is not su-ficiently sensitive to distinguish spindle cell tumors from mixed cell tumors with a low PEC. (3) Clinical 32P measurements may be affected by extraneous factors that cause large deviations from the expected values.
Assuntos
Corpo Ciliar , Neoplasias Oculares/diagnóstico , Melanoma/diagnóstico , Radioisótopos de Fósforo , Neoplasias da Coroide/diagnóstico , Humanos , Técnicas In Vitro , Contagem de CintilaçãoRESUMO
This article presents the sixth recorded example of phakomatous choristoma of the eyelid. The tumor occurred in a 4-month-old boy and was located in the lower lid near the inner canthus. The findings from light microscopy included epithelial, tubular structures with associated patches of thick, irregular basement membrane. The results of electron microscopy (ie, epithelial cells with a scarcity of organelles, homogeneous type of basement membrane, cytoplasmic microfilaments, segments of fascia occludens, and degenerated cells with peculiar interdigitations of their plasmalemmas) are all consistent with lenticular derivation, as originally proposed by Zimmerman.
Assuntos
Coristoma/patologia , Neoplasias Palpebrais/patologia , Cristalino/patologia , Membrana Basal/patologia , Coristoma/congênito , Tecido Conjuntivo/patologia , Células Epiteliais , Epitélio/ultraestrutura , Neoplasias Palpebrais/congênito , Pálpebras/patologia , Humanos , Lactente , MasculinoRESUMO
We diagnosed sebaceous gland carcinoma of the right lower eyelid in an 82-year-old man. Computed tomography showed the lesion extending from the eyelids anteriorly to the optic foramen posteriorly. With this orbital neoplasm, was an occlusion of the central retinal artery in his right eye. The right orbit was removed surgically and biopsy of the optic foramen region indicated malignant cells. Localized radiation to the right orbit was then initiated postoperatively.
Assuntos
Carcinoma/patologia , Neoplasias Palpebrais/patologia , Neoplasias Orbitárias/patologia , Neoplasias das Glândulas Sebáceas/patologia , Idoso , Carcinoma/diagnóstico , Carcinoma/cirurgia , Neoplasias Palpebrais/diagnóstico , Neoplasias Palpebrais/cirurgia , Humanos , Masculino , Neoplasias Orbitárias/diagnóstico , Neoplasias Orbitárias/cirurgia , Artéria Retiniana/patologia , Neoplasias das Glândulas Sebáceas/diagnóstico , Neoplasias das Glândulas Sebáceas/cirurgia , Tomografia Computadorizada por Raios XRESUMO
We studied the distribution pattern of sodium fluorescein in human eyes microscopically. The ciliary body showed early and diffuse leakage, with staining of the basement membrane of the nonpigmented ciliary epithelium, indicating movement of fluorescein from the ciliary body into the aqueous humor. After five minutes the iris stroma stained with fluorescein, probably from the aqueous humor. The retinal vessels and retinal pigment epithelium were impermeable to fluorescein. Corresponding to the background fluorescence seen in fluorescein angiography, fluorescence was present in Bruch's membrane and in the stroma of the inner one third of the choroid. Drusen stained most intensely in areas of greatest PAS positively. Early fluorescence of the optic disk was the result of intravascular perfusion of the dye. Minimal diffusion of fluorescein from the fenestrated choroidal vessels across the border tissue of Elschnig into the peripheral optic nerve bundles was observed. Late fluorescene of the optic disk was due mainly to fluorescein staining of the lamina scleralis and glial columns.