Dietary intervention and health in patients with systemic lupus erythematosus: A systematic review of the evidence.

Objective: The aim of this study was to evaluate the scientific evidence of dietary intervention, either through diet or supplementation, and its effects on the health of patients with systemic lupus erythematosus. Methods: Literature searches were conducted using Scopus, PubMed, BioMed Central and Science Direct databases. The terms used for the search were diet, nutritional support, nutrition therapy and systemic lupus erythematosus. Results: Eleven studies with interventions related to supplementation of omega-3 fatty acids, vitamin D and turmeric, as well as changes in diet composition, such as low glycaemic index diet were identified. Conclusions: The studies evidenced that omega-3 supplementation reduced inflammation, disease activity, endothelial dysfunction and oxidative stress; vitamin D supplementation increased serum levels, reduced inflammatory and hemostatic markers; turmeric supplementation reduced proteinuria, hematuria and systolic blood pressure; and low glycaemic index diet caused weight loss and reduced fatigue.

Fasting glucose: a cardiometabolic indicator for subclinical atherosclerosis on excess weight adolescents.

OBJECTIVE: To build a model based on cardiometabolic indicators that allow the identification of overweight adolescents at higher risk of subclinical atherosclerotic disease (SAD). METHODS: Cross-sectional study involving 161 adolescents with a body mass index ≥ +1 z-Score, aged 10 to 19 years. Carotid intima-media complex thickness (IMT) was evaluated using ultrasound to assess subclinical atherosclerotic disease. Cardiometabolic indicators evaluated included nutritional status, central adiposity, blood pressure, lipidic profile, glycemic profile, as well as age and sex. Data was presented using measures of central tendency and dispersion, as well as absolute and relative frequency. The relationship between IMT measurement (outcome variable) and other variables (independent variables) was assessed using Pearson or Spearman correlation, followed by multiple regression modeling with Gamma distribution to analyze predictors of IMT. Statistical analysis was performed using SPSS and R software, considering a significance level of 5 %. RESULTS: It was observed that 23.7 % had Carotid thickening, and the prevalence of abnormal fasting glucose was the lowest. Age and fasting glucose were identified as predictors of IMT increase, with IMT decreasing with age by approximately 1 % per year and increasing with glucose by around 0.24 % per mg/dL. CONCLUSION: The adolescent at higher risk is younger with higher fasting glycemia levels.

Effect of maternal diet on the frequency of micronuclei in pregnant women and newborns: A protocol for systematic review and meta-analysis.

BACKGROUND: The effects of diet on maternal and child genetic levels have been previously reported. Diet-associated DNA damage, such as the presence of micronuclei (MN), may be related to an increased risk of developing chronic diseases, such as cancer. Such damage is particularly concerning during pregnancy as it can affect the newborn. AIM: This review will aim to summarize the primary evidence of the impact of diet during pregnancy on micronucleus frequency in the maternal-newborn population. METHODS: This protocol was developed based on the Preferred Reporting Items guidelines for Systematic Reviews and Meta-analyses Protocol. The review was registered with the International Register of Prospective Systematic Reviews on February 17, 2022 (registration number: CRD42022302401). We will use PubMed, Embase, Web of Science, Scopus, Science direct, and Google databases to search for observational studies. This review will include studies that investigate the diet consumed by pregnant women and its effect on the frequency of MN in mothers and newborns without any time or language limitations. For data extraction, researchers will independently review the full text and collect information that characterizes the study and its findings. We will analyze the results by calculating the odds ratio for each type of diet evaluated, accompanied by a 95% confidence interval. We will perform a quantitative synthesis of homogeneous studies to perform a meta-analysis. Micronucleus frequency quantifies the effect and will be presented as the mean and standard deviation or median and interquartile range. EXPECTED RESULTS: This review will aim to identify which dietary patterns during pregnancy may be associated with an increase in the frequency of MN in mothers and their newborns. Understanding the impact of diet on the frequency of MN is essential to deepen studies and to propose strategies that aim to protect the health of the public through food.

Impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus: A systematic review and meta-analysis protocol.

BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune and inflammatory disease that requires treatment with hydroxychloroquine and glucocorticoids. Glucocorticoids are responsible for adverse effects such as increased weight, which can modify the severity and chronicity of autoimmune pathologies. AIM: To summarize scientific evidence regarding the impact of overweight and obesity on disease activity and remission in SLE. METHODS: The protocol was developed according to the Preferred Reporting Items for Systematic Review and Meta-analysis Protocol (PRISMA-P) and published in the International Prospective Register of Systematic Reviews database (PROSPERO-CRD42021268217). PubMed, Scopus, Embase, and Google Scholar will be searched for observational studies including adult patients with SLE who were overweight and obese or not, that included disease activity or remission as outcomes. The search is planned for May 2023. Three independent authors will select the eligible articles and extract their data. Subsequently, three authors will independently extract data from each included study using an extraction form created by the researchers. Methodological quality analyses will be performed using the modified Newcastle-Ottawa scale. The results will be presented as a narrative synthesis according to the synthesis without a meta-analysis reporting guideline (SWiM). Meta-analysis will be conducted where appropriate using random-effects models. EXPECTED RESULTS: This review will identify the impact of overweight and obesity on the clinical features of SLE, helping clinicians manage disease activity and remission, both important to optimize disease outcomes and patient quality of life.

Safety of hospitalized older adult patients: an analysis of the risk of falls. / Segurança do paciente idoso hospitalizado: uma análise do risco de quedas.

OBJECTIVE: To identify the risk of falls of older adults in a hospital in the Trairi region in Rio Grande do Norte, Brazil, and to describe the relationship between risk of falls and the sociodemographic characteristics of the participants. METHOD: A descriptive, transversal, and quantitative study conducted in a regional hospital, respecting the ethical principles in force. The Morse Scale was adopted for data collection, which took place in July and August 2018, and adapted with sociodemographic questions. A descriptive and inferential statistical analysis was performed. RESULTS: There were 46 participants in the study, most of whom were women with low education, and the most frequent reasons for hospitalization were surgical treatment and lung disease. More than half had a high risk of falling (54.35%), followed by moderate (32.61%) and low (13.04%). There was an association between high risk of falls, having lung disease as a reason for hospitalization and diabetes as a comorbidity. The high risk of falls was less frequent among older adult patients hospitalized for surgical treatment. CONCLUSION: The high risk of falls was found in more than half of the older adults, which varied according to the reason for hospitalization and comorbidities, being more frequent in those hospitalized for lung disease and in those who had Diabetes.

Biodegradable nanocarriers coated with polymyxin B: Evaluation of leishmanicidal and antibacterial potential.

Most treatments of leishmaniasis require hospitalization and present side effects or parasite resistance; innovations in drug formulation/reposition can overcome these barriers and must be pursued to increase therapeutic alternatives. Therefore, we tested polymyxin B (polB) potential to kill Leishmania amazonensis, adsorbed or not in PBCA nanoparticles (PBCAnp), which could augment polB internalization in infected macrophages. PBCAnps were fabricated by anionic polymerization and analyzed by Dynamic Light Scattering (size, ζ potential), Nanoparticle Tracking Analysis (size/concentration), vertical diffusion cell (release rate), drug incorporation (indirect method, protein determination) and in vitro cell viability. Nanoparticles coated with polB (PBCAnp-polB) presented an adequate size of 261.5 ± 25.9 nm, low PDI and ζ of 1.79 ± 0.17 mV (stable for 45 days, at least). The 50% drug release from PBCAnp-polB was 6-7 times slower than the free polB, which favors a prolonged and desired release profile. Concerning in vitro evaluations, polB alone reduced in vitro amastigote infection of macrophages (10 µg/mL) without complete parasite elimination, even at higher concentrations. This behavior limits its future application to adjuvant leishmanicidal therapy or antimicrobial coating of carriers. The nanocarrier PBCAnp also presented leishmanicidal effect and surpassed polB activity; however, no antimicrobial activity was detected. PolB maintained its activity against E. coli, Pseudomonas and Klebsiella, adding antimicrobial properties to the nanoparticles. Thus, this coated drug delivery system, described for the first time, demonstrated antileishmanial and antimicrobial properties. The bactericidal feature helps with concomitant prevention/treatment of secondary infections that worst ulcers induced by cutaneous L. amazonensis, ultimately ending in disfiguring or disabling lesions.

Fasting glucose: a cardiometabolic indicator for subclinical atherosclerosis on excess weight adolescents

Abstract Objective: To build a model based on cardiometabolic indicators that allow the identification of overweight adolescents at higher risk of subclinical atherosclerotic disease (SAD). Methods: Cross-sectional study involving 161 adolescents with a body mass index ≥ + 1 z-Score, aged 10 to 19 years. Carotid intima-media complex thickness (IMT) was evaluated using ultrasound to assess subclinical atherosclerotic disease. Cardiometabolic indicators evaluated included nutritional status, central adiposity, blood pressure, lipidic profile, glycemic profile, as well as age and sex. Data was presented using measures of central tendency and dispersion, as well as absolute and relative frequency. The relationship between IMT measurement (outcome variable) and other variables (independent variables) was assessed using Pearson or Spearman correlation, followed by multiple regression modeling with Gamma distribution to analyze predictors of IMT. Statistical analysis was performed using SPSS and R software, considering a significance level of 5 %. Results: It was observed that 23.7 % had Carotid thickening, and the prevalence of abnormal fasting glucose was the lowest. Age and fasting glucose were identified as predictors of IMT increase, with IMT decreasing with age by approximately 1 % per year and increasing with glucose by around 0.24 % per mg/dL. Conclusion: The adolescent at higher risk is younger with higher fasting glycemia levels.

O contexto vivido pelo familiar e pessoa em tratamento hemodialítico / The context experienced by family members and people under hemodialytic treatment / El contexto vivido por familiares y personas en tratamiento de hemodiálisis

Objetivo: compreender o contexto vivido pelo familiar e pessoa em tratamento hemodialítico. Método: estudo descritivo exploratório, qualitativo e transversal, aprovado pelo comitê de ética em pesquisa, realizado com pacientes com doença renal crônica e seus familiares, em um munícipio do interior do estado do Rio Grande do Norte, entre junho e julho de 2019. Utilizada entrevista semiestruturada, com perguntas norteadoras para a composição estrutural do genograma e ecomapa. Posteriormente à transcrição das falas, seguiu-se a leitura e construção das categorias a partir das informações encontradas. Resultados: Foram realizadas 18 entrevistas, compondo nove famílias participantes, obtendo-se as categorias: Apoio da família, Apoio externo à família, Renúncia e Enfrentamento da doença. Conclusão: a maneira com que cada paciente e família irão vivenciar o estar doente e interpretar esse significado fará essa adaptação particular e pessoal, assim como o seu enfrentamento, particularmente ao considerar que, no núcleo familiar, ocorre uma reestruturação em meio às demandas de cuidado(AU)

Objective: to understand the context experienced by the family member and person undergoing hemodialysis treatment. Method: exploratory, qualitative and cross-sectional descriptive study, approved by the research ethics committee, carried out with patients with chronic kidney disease and their families, in a municipality in the interior of the state of Rio Grande do Norte, between June and July 2019. Used semi-structured interview, with guiding questions for the structural composition of the genogram and ecomap. After transcribing the speeches, the categories were read and constructed based on the information found. Results: comprising nine participating families, 18 interviews were carried out, obtaining the categories: Family support, External support to the family, Resignation and Coping with the disease. Conclusion: the way in which each patient and family will experience being sick and interpret this meaning will make this particular and personal adaptation, as well as coping, particularly when considering that, within the family nucleus, a restructuring occurs amid the demands of care(AU)

Objetivo: comprender el contexto vivido por el familiar y la persona en tratamiento de hemodiálisis. Método: estudio descriptivo exploratorio, cualitativo y transversal, aprobado por el comité de ética en investigación, realizado con pacientes con enfermedad renal crónica y sus familiares, en un municipio del interior del estado de Rio Grande do Norte, entre junio y julio de 2019. Se utilizó una entrevista semiestructurada, con preguntas orientadoras para la composición estructural del genograma y del ecomapa. Luego de transcribir las declaraciones, se leyó la construcción de las categorías a partir de las informaciones encontradas. Resultados: Se realizaron 18 entrevistas, comprendiendo nueve familias participantes, obteniendo las categorías: Apoyo familiar, Apoyo externo a la familia, Rendimiento y Enfrentamiento de la enfermedad. Conclusión: la forma en que cada paciente y familia vivirá el estar enfermo e interpretará este significado, condicionará esa adaptación particular y personal, así como su enfrentamiento, particularmente si se considera que, dentro del núcleo familiar, se produce una reestructuración en medio de las demandas del cuidado(AU)

Segurança do paciente idoso hospitalizado: uma análise do risco de quedas / Seguridad de los pacientes ancianos hospitalizados: un análisis del riesgo de caídas / Safety of hospitalized older adult patients: an analysis of the risk of falls

RESUMO Objetivo Identificar o risco de quedas em idosos em um hospital da região do Trairi, no Rio Grande do Norte; descrever a relação entre risco de quedas e as características sociodemográficas dos participantes. Método Estudo descritivo, transversal, quantitativo, realizado em um hospital regional, respeitando os princípios éticos vigentes. Para a coleta, ocorrida em julho e agosto de 2018, foi adotada a Escala de Morse, adaptada com questões sociodemográficas. Realizada análise estatística descritiva e inferencial. Resultados O estudo teve 46 participantes, dos quais a maioria era formada por mulheres, com baixa escolaridade e os motivos de internação mais frequentes foram tratamento cirúrgico e doença pulmonar. Mais da metade apresentou risco alto de sofrer quedas (54,35%), seguido de moderado (32,61%) e baixo (13,04%). Houve associação entre risco alto de quedas, ter doença pulmonar como motivo de internação e diabetes como comorbidade. O risco alto de quedas foi menos frequente entre idosos internados para tratamento cirúrgico. Conclusão O risco alto para quedas foi encontrado em mais da metade dos idosos, o que variou de acordo com o motivo de internação e comorbidades, sendo mais frequentes naqueles internados por doença pulmonar e que apresentavam Diabetes.

RESUMEN Objetivo Identificar el riesgo de caídas en ancianos en un hospital de la región del Trairi, en Rio Grande do Norte; describir la relación entre riesgo de caídas y las características sociodemográficas de los participantes. Método Estudio descriptivo, transversal, cuantitativo, realizado en un hospital regional, respetando los principios éticos vigentes. Para la recolección de datos, ocurrida en julio y agosto de 2018, fue adoptada la Escala de Morse, adaptada con cuestiones sociodemográficas. Realizado análisis estadística descriptiva y inferencial. Resultados El estudio tuve 46 participantes, de los cuales la mayoría era formada por mujeres, con baja escolaridad y los motivos de internamiento más frecuentes fueran tratamiento quirúrgico y enfermedad pulmonar. Más de la mitad presento riesgo alto de sufrir caídas (54,35%), seguido de moderado (32,61%) y bajo (13,04%). Hubo asociación entre riesgo alto de caídas, tener enfermedad pulmonar como motivo de internamiento y diabetes como comorbilidad. El riesgo alto de caídas fue menos frecuente entre ancianos internados para tratamiento quirúrgico. Conclusión El riesgo alto para caídas fue encontrado en más de la mitad de los ancianos, lo que varió de acuerdo con el motivo de internamiento y comorbilidades, siendo más frecuentes en los internados por enfermedad pulmonar y que presentaban Diabetes.

ABSTRACT Objective To identify the risk of falls of older adults in a hospital in the Trairi region in Rio Grande do Norte, Brazil, and to describe the relationship between risk of falls and the sociodemographic characteristics of the participants. Method A descriptive, transversal, and quantitative study conducted in a regional hospital, respecting the ethical principles in force. The Morse Scale was adopted for data collection, which took place in July and August 2018, and adapted with sociodemographic questions. A descriptive and inferential statistical analysis was performed. Results There were 46 participants in the study, most of whom were women with low education, and the most frequent reasons for hospitalization were surgical treatment and lung disease. More than half had a high risk of falling (54.35%), followed by moderate (32.61%) and low (13.04%). There was an association between high risk of falls, having lung disease as a reason for hospitalization and diabetes as a comorbidity. The high risk of falls was less frequent among older adult patients hospitalized for surgical treatment. Conclusion The high risk of falls was found in more than half of the older adults, which varied according to the reason for hospitalization and comorbidities, being more frequent in those hospitalized for lung disease and in those who had Diabetes.

Transtorno mental comum em idosos com doenças crônicas não transmissíveisna atenção primária à saúde / Trastorno mental común en los ancianos con enfermedades crónicas no transmisiblesen la atención primaria de salud / Common mental disorder in elderly people with chronic non-communicable diseases in primary health care

RESUMO Objetivo: Identificar o risco de Transtorno Mental Comum em idosos com Doenças Crônicas Não Transmissíveis e identificar sua relação com características sociodemográficas. Métodos: Estudo transversal, exploratório-descritivo, de abordagem quantitativa, desenvolvido na Estratégia Saúde da Família do Município de São Vicente/RN, com amostra de 99 idosos. A coleta ocorreu em setembro e outubro de 2018 mediante entrevista estruturada com aplicação do Self-Reporting Questionnaire-20,no domicílio. Foi realizada análise estatística descritiva e inferencial. Resultados: Foi identificado que 28,28% dos idosos apresentaram alto risco para Transtorno Mental Comum e a maioria (71,72%) tinha risco baixo. Não houve associação significativa deste risco com as Doenças Crônicas Não Transmissíveis e com características sociodemográficas. Conclusão: Apesar de não ter sido identificada associação estatística, é preocupante a presença de sofrimento psíquico em idosos com doenças crônicas, tendo em vista o possível comprometimento de sua qualidade de vida. Tal fato reafirma a importância de desenvolvimento de estratégias para detecção e acompanhamento de idosos com Transtorno Mental Comum nesse contexto de atenção à saúde.

RESUMEN Objetivo: identificar el riesgo de Trastorno Mental Común en personas mayores con Enfermedades Crónicas No Transmisibles e identificar su relación con características sociodemográficas. Métodos: estudio transversal, exploratorio-descriptivo, de abordaje cuantitativo, desarrollado en la Estrategia Salud de la Familia del Municipio de São Vicente/RN, con muestra de 99 ancianos. La recolección ocurrió en septiembre y octubre de 2018 mediante entrevista estructurada con aplicación del Self-Reporting Questionnaire-20, en el domicilio. Fue realizado análisis estadístico descriptivo e inferencial. Resultados: fue identificado que el 28,28% de los ancianos presentó alto riesgo para Trastorno Mental Común y la mayoría (71,72%) tenía riesgo bajo. No hubo asociación significativa de este riesgo con las Enfermedades Crónicas No Transmisibles y con características sociodemográficas. Conclusión: a pesar de no haber sido identificada asociación estadística, es preocupante la presencia de sufrimiento psíquico en personas mayores con enfermedades crónicas, considerando el posible comprometimiento de su calidad de vida. Tal hecho reafirma la importancia del desarrollo de estrategias para detección y acompañamiento de ancianos con Trastorno Mental Común en este contexto de la atención primaria de salud.

abstract Objective: To identify the risk of Common Mental Disorder in elderly people with Chronic Non-communicable Diseases and identify its relationship with sociodemographic characteristics. Methods: Cross-sectional, exploratory and descriptive study with quantitative approach, developed in the Family Health Strategy of the Municipality of São Vicente/RN, with a sample of 99 elderly people. The collection took place in September and October 2018 through a structured interview at the participants' homes using the Self-Reporting Questionnaire-20. Descriptive and inferential statistical analyses were performed. Results: It was found that 28.28% of the elderly had high risk for Common Mental Disorder and most (71.72%) had low risk. There was no significant association of this risk with Chronic Non-communicable Diseases and sociodemographic characteristics. Conclusion: Although no statistical association was identified, the presence of psychological distress in elderly people with chronic diseases is a source of concern, considering the possible impairment of their quality of life. Thus, the study stresses the importance of developing strategies for detection and monitoring of elderly people with Common Mental Disorder in this context of health care.

Transtorno mental comum em idosos com doenças crônicas não transmissíveis na atenção primária à saúde / Common mental disorder in elderly people with chronic non-communicable diseases in primary health care

Objective:To identify the risk of Common Mental Disorder in elderly people with Chronic Non-communicable Diseases and identify its relationship with sociodemographic characteristics. Methods:Cross-sectional, exploratory and descriptive study with quantitative approach, developed in the Family Health Strategy of the Municipality of São Vicente/RN, with a sample of 99 elderly people. The collection took place in September and October 2018 through a structured interview at the participants' homes using the Self-Reporting Questionnaire-20. Descriptive and inferential statistical analyses were performed. Results:It was found that 28.28% of the elderly had high risk for Common Mental Disorder and most (71.72%) had low risk. There was no significant association of this risk with Chronic Non-communicable Diseases and sociodemographic characteristics. Conclusion: Although no statistical association was identified, the presence of psychological distress in elderly people with chronic diseases is a source of concern, considering the possible impairment of their quality of life. Thus, the study stresses the importance of developing strategies for detection and monitoring of elderly people with Common Mental Disorder in this context of health care.

Objetivo: Identificar o risco de Transtorno Mental Comum em idosos com Doenças Crônicas Não Transmissíveis e identificar sua relação com características sociodemográficas. Métodos: Estudo transversal, exploratório-descritivo, de abordagem quantitativa, desenvolvido na Estratégia Saúde da Família do Município de São Vicente/RN, com amostra de 99 idosos. A coleta ocorreu em setembro e outubro de 2018 mediante entrevista estruturada com aplicação do Self-Reporting Questionnaire-20,no domicílio. Foi realizada análise estatística descritiva e inferencial. Resultados: Foi identificado que 28,28% dos idosos apresentaram alto risco para Transtorno Mental Comum e a maioria (71,72%) tinha risco baixo. Não houve associação significativa deste risco com as Doenças Crônicas Não Transmissíveis e com características sociodemográficas. Conclusão:Apesar de não ter sido identificada associação estatística, é preocupante a presença de sofrimento psíquico em idosos com doenças crônicas, tendo em vista o possível comprometimento de sua qualidade de vida. Tal fato reafirma a importância de desenvolvimento de estratégias para detecção e acompanhamento de idosos com Transtorno Mental Comum nesse contexto de atenção à saúde.

Intoxicação aguda por agrotóxicos anticolinesterásicos na cidade do Recife, Pernambuco, 2007-2010 / Acute anticholinesterase pesticide poisoning in Recife, Pernambuco State, Brazil, 2007-2010 / Intoxicación aguda por agrotóxicos anticolinesterásicos en la ciudad de Recife, Pernambuco, 2007-2010

Objetivo: descrever as características epidemiológicas e a distribuição espacial dos casos de intoxicações agudas por agrotóxicos anticolinesterásicos na cidade do Recife, estado de Pernambuco, Brasil, no período 2007-2010. Métodos: estudo descritivo das notificações registradas no Sistema de Informação de Agravos de Notificação (Sinan), para levantamento do perfil epidemiológico e geoprocessamento. Resultados: foram identificados 549 casos de intoxicações agudas por agrotóxicos anticolinesterásicos, sendo as maiores frequências observadas no sexo feminino (60,3 por cento), na faixa etária de 15 a 29 anos (42,3 por cento) e naqueles de cor ou raça parda (95,3 por cento); o "chumbinho" representou o principal agente tóxico envolvido (92,2 por cento) e o principal motivo das intoxicações foi a tentativa de suicídio (79,4 por cento). Conclusão: a intoxicação por agrotóxicos anticolinesterásicos acometeu principalmente mulheres, jovens e pardos; o achado de que a grande maioria dos casos estava relacionada a tentativa de suicídio indica a necessidade de ações de prevenção focadas na população detectada como vulnerável.

Objective: to describe the epidemiological characteristics and spatial distribution of acute anticholinesterase pesticide poisoning cases in the city of Recife Pernambuco State, Brazil, 2007-2010. Methods: this was a descriptive study of cases reported on the Notifiable Diseases Database (Sinan) to obtain their epidemiologic profile and perform geoprocessing. Results: 549 cases were identified. The highest frequencies occurred among females (60.3 percent), the 15-29 age group (42.3 percent) and brown-skinned individuals (95.3 percent). "Rat poison" was the main poisoning agent found (92.2 percent) and attempted suicide was the main reason for poisoning (79.4 percent). Conclusion: anticholinesterase pesticide poisoning is a serious public health problem with a high proportion of cases concentrated in youth, women and brown-skinned people. The finding that the vast majority of cases were related to attempted suicide indicates the need for prevention actions focusing vulnerable populations.

Objetivo: describir las características epidemiológicas y la distribución espacial de los casos de intoxicaciones agudas por agrotóxicos anticolinesterásicos en la ciudad de Recife, estado de Pernambuco, Brasil, en el período 2007-2010.Métodos: estudio descriptivo de las notificaciones registradas en el Sistema de Información de Agravamientos de Notificación (Sinan), para analizar el perfil epidemiológico y el geoprocesamiento.Resultados: se identificaron 549 casos de intoxicaciones agudas por agrotóxicos anticolinesterásicos, siendo observadas las mayores frecuencias en el sexo femenino (60,3%), en la franja de edad de 15 a 29 años (42,3%) y en las personas de color o raza parda (95,3%); el rodenticida ("chumbinho") fue el principal agente tóxico involucrado (92,2%) y el principal motivo de las intoxicaciones fue el intento de suicidio (79,4%). Conclusion: la intoxicación por agrotóxicos anticolinesterásicos acometió principalmente a mujeres, jóvenes y a pardos; el hallazgo de que en la gran mayoría de los casos estaba relacionada al intento de suicidio indica la necesidad de acciones de prevención dirigidas a la población detectada como vulnerable.

Retinocoroidite toxoplásmica reativada provavelmente por cirurgia refrativa: laser in situ keratomileusis - LASIK / Probable reactivation of toxoplasmic retinochoroiditis by refractive surgery: laser in situ keratomileusis - LASIK

O presente trabalho objetiva demonstrar provável relaço entre recorrência de toxoplasmose ocular e cirurgia refrativa (LASIK). Trata-se de relato de caso de um paciente de 33 anos de idade com recorrência de retinocoroidite toxoplásmica após cirurgia de LASIK. O exame fundoscópico do olho esquerdo revelou foco de retinocoroidite em atividade, satélite a cicatriz antiga de toxoplasmose ocular, 17 dias após cirurgia de LASIK. Os autores apresentam subsídios para o estabelecimento de relação causal entre LASIK e a reativação de retinocoroidite toxoplasmática.

The aim of this article is to demonstrate the probable relationship between the recurrence of toxoplasmic retinochoroiditis and refractive surgery (LASIK). The case consists in a toxoplasmic retinochoroditis recurrence observed in a 33-year-old patient after a LASIK surgery. Fundoscopy revealed a retinochoroiditis focus in activity in the left eye seventeen days after the surgery, adjacent to an old scar of ocular toxoplasmosis. The authors present findings that reinforce possible causal links between LASIK and the recurrence of toxoplasmic retinochoroiditis.