Detalhe da pesquisa
1.
Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.
Chembiochem
; 23(1): e202100441, 2022 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34726826
2.
A two-pronged attack on antibiotic-resistant microbes.
Nature
; 589(7843): 517-518, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33432214
3.
SPAK and OSR1 kinases bind and phosphorylate the ß2-Adrenergic receptor.
Biochem Biophys Res Commun
; 532(1): 88-93, 2020 10 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32828531
4.
The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.
Chembiochem
; 21(5): 638-643, 2020 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31614064
5.
Sequence specific assignment and determination of OSR1 C-terminal domain structure by NMR.
Biochem Biophys Res Commun
; 512(2): 338-343, 2019 04 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30894278
6.
C-terminal phosphorylation of SPAK and OSR1 kinases promotes their binding and activation by the scaffolding protein MO25.
Biochem Biophys Res Commun
; 503(3): 1868-1873, 2018 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30060950
7.
Chemical Strategies for Activating PINK1, a Protein Kinase Mutated in Parkinson's Disease.
Chembiochem
; 19(23): 2433-2437, 2018 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30248222
8.
The Photosensitising Clinical Agent Verteporfin Is an Inhibitor of SPAK and OSR1 Kinases.
Chembiochem
; 19(19): 2072-2080, 2018 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29999233
9.
The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.
Chembiochem
; 19(5): 425-429, 2018 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29226533
10.
Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors.
Chembiochem
; 18(5): 460-465, 2017 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28004876
11.
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.
EMBO J
; 30(9): 1730-41, 2011 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21423148
12.
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.
Biochem J
; 451(1): 111-22, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23387299
13.
Structural insights into the activation of MST3 by MO25.
Biochem Biophys Res Commun
; 431(3): 604-9, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23296203
14.
SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.
Biochem J
; 441(1): 325-37, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22032326
15.
Parkinson's Disease: Are PINK1 Activators Inching Closer to the Clinic?
ACS Med Chem Lett
; 14(7): 870-874, 2023 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37465300
16.
PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage.
J Med Chem
; 66(11): 7645-7656, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37248632
17.
Synthesis of pdCpAs and transfer RNAs activated with thiothreonine and derivatives.
Bioorg Med Chem
; 20(8): 2679-89, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22405920
18.
Aryloxy Pivaloyloxymethyl Prodrugs as Nucleoside Monophosphate Prodrugs.
J Med Chem
; 64(22): 16703-16710, 2021 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34734726
19.
Generation of Stable Isopentenyl Monophosphate Aryloxy Triester Phosphoramidates as Activators of Vγ9Vδ2 T Cells.
ChemMedChem
; 16(15): 2375-2380, 2021 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33899332
20.
Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism.
Bioorg Med Chem
; 18(7): 2439-46, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20299228