Detalhe da pesquisa
1.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
2.
Targeting Plasmodium PI(4)K to eliminate malaria.
Nature
; 504(7479): 248-253, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24284631
3.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
4.
Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class.
J Am Chem Soc
; 138(23): 7268-71, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27244042
5.
The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.
PLoS Med
; 9(2): e1001169, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22363211
6.
Anopheles gambiae PGRPLC-mediated defense against bacteria modulates infections with malaria parasites.
PLoS Pathog
; 5(8): e1000542, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19662170
7.
Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.
Sci Rep
; 11(1): 2121, 2021 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33483532
8.
8-Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual-Stage Antiplasmodial Activity.
ChemMedChem
; 14(4): 501-511, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30605243
9.
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone.
Commun Biol
; 2: 166, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31069275
10.
Substituted Aminoacetamides as Novel Leads for Malaria Treatment.
ChemMedChem
; 14(14): 1329-1335, 2019 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31188540
11.
Developing Plasmodium vivax Resources for Liver Stage Study in the Peruvian Amazon Region.
ACS Infect Dis
; 4(4): 531-540, 2018 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29542317
12.
One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.
Eur J Med Chem
; 158: 801-813, 2018 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30245402
13.
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
Science
; 362(6419)2018 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30523084
14.
Design and Synthesis of Terephthalic Acid-Based Histone Deacetylase Inhibitors with Dual-Stage Anti-Plasmodium Activity.
ChemMedChem
; 12(19): 1627-1636, 2017 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28812327
15.
3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally.
J Med Chem
; 60(14): 6036-6044, 2017 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28653845
16.
Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.
ACS Infect Dis
; 2(11): 816-826, 2016 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27933786
17.
High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.
Cell Host Microbe
; 19(1): 114-26, 2016 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26749441
18.
High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria.
ACS Infect Dis
; 2(4): 281-293, 2016 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27275010
19.
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.
J Med Chem
; 59(21): 9672-9685, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27631715
20.
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.
J Med Chem
; 59(21): 9890-9905, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27748596