Detalhe da pesquisa
1.
Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis.
Molecules
; 27(14)2022 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35889319
2.
First-Time-in-Human Study and Prediction of Early Bactericidal Activity for GSK3036656, a Potent Leucyl-tRNA Synthetase Inhibitor for Tuberculosis Treatment.
Antimicrob Agents Chemother
; 63(8)2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31182528
3.
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
Proc Natl Acad Sci U S A
; 113(31): E4523-30, 2016 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27432954
4.
Development of an Intracellular Screen for New Compounds Able To Inhibit Mycobacterium tuberculosis Growth in Human Macrophages.
Antimicrob Agents Chemother
; 60(1): 640-5, 2016 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26503663
5.
New molecular settings to support in vivo anti-malarial assays.
Malar J
; 15: 147, 2016 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26955872
6.
Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes.
Science
; 381(6657): 533-540, 2023 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37535741
7.
Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis.
Antimicrob Agents Chemother
; 56(11): 5782-9, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22926567
8.
Comparison of 8 weeks standard treatment (rifampicin plus clarithromycin) vs. 4 weeks standard plus amoxicillin/clavulanate treatment [RC8 vs. RCA4] to shorten Buruli ulcer disease therapy (the BLMs4BU trial): study protocol for a randomized controlled multi-centre trial in Benin.
Trials
; 23(1): 559, 2022 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35804454
9.
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis.
Sci Transl Med
; 14(643): eaaz6280, 2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35507672
10.
Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis.
ACS Infect Dis
; 7(1): 141-152, 2021 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33319550
11.
Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening.
PLoS Negl Trop Dis
; 13(1): e0007126, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30689630
12.
Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence.
Sci Adv
; 5(3): eaav2104, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30906866
13.
Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis.
ACS Infect Dis
; 5(8): 1433-1445, 2019 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31184461
14.
Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach.
Sci Rep
; 8(1): 12664, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30140040
15.
Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.
Sci Rep
; 8(1): 13473, 2018 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30194385
16.
Functional screening of selective mitochondrial inhibitors of Plasmodium.
Int J Parasitol Drugs Drug Resist
; 8(2): 295-303, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29775797
17.
Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.
ChemMedChem
; 13(7): 672-677, 2018 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29399991
18.
Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.
Nat Commun
; 9: 16227, 2018 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30004092
19.
Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).
J Med Chem
; 60(19): 8011-8026, 2017 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28953378
20.
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.
Nat Commun
; 8: 16081, 2017 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28714473