Detalhe da pesquisa
1.
Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression.
Acta Pharmacol Sin
; 45(5): 890-899, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38177693
2.
Targeting PI3Kα overcomes resistance to KRasG12C inhibitors mediated by activation of EGFR and/or IGF1R.
Acta Pharmacol Sin
; 44(5): 1083-1094, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36411339
3.
The double faced role of xanthine oxidoreductase in cancer.
Acta Pharmacol Sin
; 43(7): 1623-1632, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34811515
4.
SAF-248, a novel PI3Kδ-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma.
Acta Pharmacol Sin
; 43(1): 209-219, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33782541
5.
Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo[2,1-f][1,2,4]triazine derivatives.
Bioorg Med Chem Lett
; 30(12): 127194, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32317209
6.
Emerging roles of class I PI3K inhibitors in modulating tumor microenvironment and immunity.
Acta Pharmacol Sin
; 41(11): 1395-1402, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32939035
7.
CRISPR-cas9: a powerful tool towards precision medicine in cancer treatment.
Acta Pharmacol Sin
; 41(5): 583-587, 2020 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-31792341
8.
Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening.
Acta Pharmacol Sin
; 41(3): 423-431, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31197246
9.
Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CAH1047R accompanied with pro-tumorigenic secretome.
Int J Cancer
; 145(3): 817-829, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30671946
10.
Design, synthesis, and biological activity evaluation of (-)-6-O-desmethylantofine analogues as potent anti-cancer agents.
Bioorg Med Chem
; 27(14): 3070-3081, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31171403
11.
Oncogene-induced senescence: a double edged sword in cancer.
Acta Pharmacol Sin
; 39(10): 1553-1558, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-29620049
12.
The mTOR inhibitor AZD8055 overcomes tamoxifen resistance in breast cancer cells by down-regulating HSPB8.
Acta Pharmacol Sin
; 39(8): 1338-1346, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-29345254
13.
Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-RafV600E inhibitors.
Acta Pharmacol Sin
; 38(7): 1059-1068, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28414204
14.
Dipotassium N-stearoyltyrosinate ameliorated pathological injuries in triple-transgenic mouse model of Alzheimer's disease.
J Pharmacol Sci
; 132(1): 92-99, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27671351
15.
Targeting PI3Kδ: emerging therapy for chronic lymphocytic leukemia and beyond.
Med Res Rev
; 35(4): 720-52, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25763934
16.
Toward rapamycin analog (rapalog)-based precision cancer therapy.
Acta Pharmacol Sin
; 36(10): 1163-9, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26299952
17.
PI3K isoform-selective inhibitors: next-generation targeted cancer therapies.
Acta Pharmacol Sin
; 36(10): 1170-6, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26364801
18.
HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer.
Int J Cancer
; 135(10): 2462-74, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24706460
19.
DW09849, a selective phosphatidylinositol 3-kinase (PI3K) inhibitor, prevents PI3K signaling and preferentially inhibits proliferation of cells containing the oncogenic mutation p110α (H1047R).
J Pharmacol Exp Ther
; 348(3): 432-41, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24361696
20.
Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells.
J Biol Chem
; 287(15): 12132-41, 2012 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22337890