RESUMO
We report an efficient method for the preparation of unprecedented head-to-tail cyclic sulfono-γ-AApeptides. Following this method, a number of cyclic sequences bearing two to five subunits were efficiently synthesized. In addition, the X-ray crystal structure study of a three-membered cyclic sulfono-γ-AApeptide revealed a type II ß-turn-like character.
Assuntos
Aminoácidos Sulfúricos/química , Peptídeos Cíclicos/síntese química , Peptidomiméticos/síntese química , Cristalografia por Raios X , Ciclização , Estrutura Molecular , Peptídeos Cíclicos/química , Peptidomiméticos/químicaRESUMO
Personal interviews were conducted with biochemistry faculty during which they were presented with student performances on a content survey. From these interviews, four themes that reflect faculty responses to the surveys emerged: awareness of student understanding, self-reflection on teaching practice, planned collaboration with colleagues, and emotional reactions. Here, we discuss these themes and their implications for creating conversation designed to promote reflection on biochemistry teaching. © 2018 by The International Union of Biochemistry and Molecular Biology, 46:382-389, 2018.