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Environ Toxicol Pharmacol ; 93: 103887, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35598755

RESUMO

Microcystin-LR (MC-LR) is a potent cyanotoxin that can reach several organs. However subacute exposure to sublethal doses of MC-LR has not yet well been studied. Herein, we evaluated the outcomes of subacute and sublethal MC-LR exposure on lungs. Male BALB/c mice were exposed to MC-LR by gavage (30 µg/kg) for 20 consecutive days, whereas CTRL mice received filtered water. Respiratory mechanics was not altered in MC-LR group, but histopathology disclosed increased collagen deposition, immunological cell infiltration, and higher percentage of collapsed alveoli. Mitochondrial function was extensively affected in MC-LR animals. Additionally, a direct in vitro titration of MC-LR revealed impaired mitochondrial function. In conclusion, MC-LR presented an intense deleterious effect on lung mitochondrial function and histology. Furthermore, MC-LR seems to exert an oligomycin-like effect in lung mitochondria. This study opens new perspectives for the understanding of the putative pulmonary initial mechanisms of damage resulting from oral MC-LR intoxication.


Assuntos
Microcistinas , Mitocôndrias , Animais , Ingestão de Alimentos , Pulmão , Masculino , Toxinas Marinhas , Camundongos , Microcistinas/metabolismo , Microcistinas/toxicidade , Oligomicinas/metabolismo , Oligomicinas/farmacologia
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