Detalhe da pesquisa
1.
Application of blood microsampling in cynomolgus monkey and demonstration of equivalent monoclonal antibody PK parameters compared to conventional sampling.
Pharm Res
; 38(5): 819-830, 2021 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-33982224
2.
Modeling the clinical phenotype of BTK inhibition in the mature murine immune system.
J Immunol
; 193(1): 185-97, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24899507
3.
Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis.
J Immunol
; 191(9): 4540-50, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24068666
4.
Mechanistic investigations of test article-induced pancreatic toxicity at the endocrine-exocrine interface in the rat.
Toxicol Pathol
; 42(1): 229-42, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24226507
5.
Anti-Drug Antibody Incidence Comparison of Therapeutic Proteins Administered Via Subcutaneous vs. Intravenous Route.
AAPS J
; 26(3): 60, 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38730115
6.
Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.
PLoS One
; 18(1): e0280590, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36662882
7.
Substituted N-aryl-6-pyrimidinones: a new class of potent, selective, and orally active p38 MAP kinase inhibitors.
Bioorg Med Chem Lett
; 21(13): 3856-60, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21620699
8.
Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase.
Bioorg Med Chem Lett
; 21(13): 4066-71, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21641211
9.
Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase.
Bioorg Med Chem Lett
; 21(13): 4059-65, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21640588
10.
Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation peptides parallels pathologic changes.
Arthritis Rheum
; 62(10): 3006-15, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20533541
11.
Safety, Tolerability, and Pharmacokinetics of PF-06823859, an Anti-Interferon ß Monoclonal Antibody: A Randomized, Phase I, Single- and Multiple-Ascending-Dose Study.
Clin Pharmacol Drug Dev
; 10(3): 307-316, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33352008
12.
Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase.
Bioorg Med Chem Lett
; 20(8): 2634-8, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20227876
13.
Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.
Toxicol Pathol
; 38(4): 606-18, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20448081
14.
A Physiologically-Based Pharmacokinetic Model for the Prediction of "Half-Life Extension" and "Catch and Release" Monoclonal Antibody Pharmacokinetics.
CPT Pharmacometrics Syst Pharmacol
; 9(9): 534-541, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32697437
15.
Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation.
J Pharmacol Exp Ther
; 331(3): 882-95, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19720877
16.
Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
ACS Med Chem Lett
; 10(1): 80-85, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655951
17.
Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
J Med Chem
; 61(23): 10415-10439, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30130103
18.
Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis.
J Med Chem
; 59(1): 313-27, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26653735
19.
Predicting drug-drug interactions in drug discovery: where are we now and where are we going?
Curr Opin Drug Discov Devel
; 8(1): 51-8, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15679172
20.
Discovery and characterization of atropisomer PH-797804, a p38 MAP kinase inhibitor, as a clinical drug candidate.
ChemMedChem
; 7(2): 273-80, 2012 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22174080