1.
Org Lett
; 3(16): 2461-4, 2001 Aug 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11483035
RESUMO
[reaction: see text] This work describes the synthesis of two novel macrocyclic taxoid constructs by ring-closing olefin metathesis (RCM) and their biological evaluation. Computational studies examine conformational profiles of 1 and 2 for their fit to the beta-tubulin binding site determined by electron crystallography. The results support the hypothesis that paclitaxel binds to microtubules in a "T" conformation.