Detalhe da pesquisa
1.
SMN protein is required throughout life to prevent spinal muscular atrophy disease progression.
Hum Mol Genet
; 31(1): 82-96, 2021 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34368854
2.
Pharmacologically induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.
Hum Mol Genet
; 25(5): 964-75, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26758873
3.
Corrigendum to: Pharmacologically-induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.
Hum Mol Genet
; 30(9): 843, 2021 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33201218
4.
Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy.
Hum Mol Genet
; 25(10): 1885-1899, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26931466
5.
Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function.
Hum Mol Genet
; 22(13): 2626-33, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23462290
6.
Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1.
Brain
; 137(Pt 5): 1374-93, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24681663
7.
Molecular, physiological, and motor performance defects in DMSXL mice carrying >1,000 CTG repeats from the human DM1 locus.
PLoS Genet
; 8(11): e1003043, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23209425
8.
PEGylation of lysine residues reduces the pro-migratory activity of IGF-I.
Biochim Biophys Acta
; 1830(10): 4734-42, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23800578
9.
Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.
Brain
; 136(Pt 3): 957-70, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23404338
10.
Brain expression profiles of two SCN1A antisense RNAs in children and adolescents with epilepsy.
Transl Neurosci
; 15(1): 20220330, 2024 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38283997
11.
Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo.
Mol Ther Nucleic Acids
; 34: 102055, 2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37928443
12.
Separation of fast from slow anabolism by site-specific PEGylation of insulin-like growth factor I (IGF-I).
J Biol Chem
; 286(22): 19501-10, 2011 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21460230
13.
Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy.
Neurobiol Dis
; 47(1): 1-12, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22426397
14.
Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity.
Amyotroph Lateral Scler
; 13(5): 418-29, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22871074
15.
Enhanced dentate gyrus synaptic plasticity but reduced neurogenesis in a mouse model of amyloidosis.
Neurobiol Dis
; 40(2): 386-93, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20615468
16.
Overlap of Peak Growth Activity and Peak IGF-1 to IGFBP Ratio: Delayed Increase of IGFBPs versus IGF-1 in Serum as a Mechanism to Speed up and down Postnatal Weight Gain in Mice.
Cells
; 9(6)2020 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32580353
17.
Cortical hypoperfusion in the B6.PS2APP mouse model for Alzheimer's disease: comprehensive phenotyping of vascular and tissular parameters by MRI.
Magn Reson Med
; 62(1): 35-45, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19449370
18.
Nerve sprouting capacity in a pharmacologically induced mouse model of spinal muscular atrophy.
Sci Rep
; 9(1): 7799, 2019 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31127156
19.
Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease.
J Neurosci
; 27(4): 824-31, 2007 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-17251422
20.
ProNGF inhibits NGF-mediated TrkA activation in PC12 cells.
J Neurochem
; 107(5): 1294-303, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18796003