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1.
Science ; 215(4533): 690-1, 1982 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-17842404

RESUMO

A single heat transfer measurement technique was used to determine the thermal insulating capabilities of four materials used in outdoor clothing-goose down, wool, polyester, and polyolefin. It was found that all provide very similar degrees of insulation.

2.
J Anim Sci ; 71(5): 1081-7, 1993 May.
Artigo em Inglês | MEDLINE | ID: mdl-8505237

RESUMO

Effects of different doses of zeranol on ADG, hemoglobin (Hb), feed efficiency (FE), and carcass traits were evaluated in special-fed veal calves in two trials. On d 0, calves were implanted subcutaneously in the middle third of the ear with either 0 (control, placebo pellet), 12, 24, 36, or 48 mg of zeranol. Trial 1 was conducted from February through May 1990 with 120 Holstein bull calves (17 to 21 d of age on d 0) and Trial 2 was conducted from May through August 1991 with 100 Holstein bull calves (24 to 28 d of age d 0). Calves were fed on an individual calf basis. Calves in Trial 1 that were implanted with 48 mg of zeranol had improved FE (P < .05) and ADG (P < .05) during Period 1 (0 to 43 d). No significant differences in ADG or FE were observed among treatments in Trial 2. Hemoglobin levels at slaughter averaged 7.88 +/- .096 and 8.19 +/- .149 g/dL over all treatments for Trials 1 and 2, respectively. The only postslaughter trait affected by zeranol dose was testicular weight. In both trials, testicular weight at slaughter decreased (P < .05) with increasing doses of zeranol. Dressing percentage tended to be higher for 48-mg implants than for controls but the difference was not significant. There were no significant zeranol dose effects on longissimus muscle area, flank color, carcass conformation, or percentage of fore- vs hind-quarter weight. These results indicated that higher doses of zeranol improved ADG and FE during the first 6 wk after the trial period (to 8 wk of age), decreased testicular weight, and increased hide-on carcass dressing percentage for calves implanted with 48 mg of zeranol compared with those that received 0 mg of zeranol.


Assuntos
Bovinos/crescimento & desenvolvimento , Hemoglobinas/efeitos dos fármacos , Carne/normas , Zeranol/farmacologia , Animais , Bovinos/sangue , Implantes de Medicamento , Ingestão de Alimentos/efeitos dos fármacos , Masculino , Tamanho do Órgão/efeitos dos fármacos , Distribuição Aleatória , Testículo/efeitos dos fármacos , Testículo/crescimento & desenvolvimento , Aumento de Peso/efeitos dos fármacos , Zeranol/administração & dosagem
4.
Kidney Int ; 48(2): 344-53, 1995 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-7564101

RESUMO

Sorbitol plus myo-inositol, betaine and glycerophosphorylcholine (GPC) are cellular osmolytes in the mammalian renal medulla. Galactosemia and hyperglycemia can cause excessive levels of galactitol or sorbitol in several organs via aldose reductase (AR) catalysis. AR inhibitors can reduce these polyols. To examine osmolyte responses to polyol perturbations, male Wistar rats were fed normal diet, the AR inhibitor sorbinil (at 40 mg/kg/d), 25% galactose, or a combination, for 10, 21 and 42 days. All animals at 21 days had higher apparent renal AR activity than at 10 or 42 days, possibly providing resistance to sorbinil. Sorbinil feeding alone tended to increase urinary, plasma and renal urea levels. It reduced AR activity and sorbitol contents in renal inner medulla, though less so at 21 days; other renal osmolytes, especially betaine, were elevated. Galactose feeding caused little change in renal AR activity, and resulted in high galactose and galactitol contents in renal medulla, urine, blood and lens (and higher renal Na+ contents at 10 days). Renal sorbitol, inositol and GPC decreased, while betaine contents trended higher at all times. Sorbinilgalactose feeding reduced renal AR activities and galactitol contents (again less so at 21 days), urine, blood and lens galactitol, and further reduced renal sorbitol contents. At 10 and 21 days it tended to raise renal betaine more, and restore inositol (but not GPC) contents to control levels. At 42 days it reduced renal and urinary Na+ and galactose, and decreased renal betaine to control levels. Under most conditions, total renal (non-urea) organic osmolyte contents (presumed to be mostly intracellular) and Na+ plus galactose contents (presumed mostly extracellular) changed together such that cell volumes may have been maintained. The exception was 10 days on galactose, where total osmolytes appeared too low. In galactose-fed animals, urine/plasma ratios suggest some renal galactitol efflux, and cellular galactitol probably helps maintain osmotic balance rather than cause swelling.


Assuntos
Sangue/metabolismo , Galactose/farmacologia , Imidazóis/farmacologia , Imidazolidinas , Rim/metabolismo , Cristalino/metabolismo , Urina/química , Aldeído Redutase/antagonistas & inibidores , Aldeído Redutase/metabolismo , Ração Animal , Animais , Combinação de Medicamentos , Galactose/administração & dosagem , Imidazóis/administração & dosagem , Rim/citologia , Masculino , Ratos , Ratos Wistar , Fatores de Tempo
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