Pesquisa | Portal de Pesquisa da BVS

1.

PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.

Chen, Hongxia; Bai, Yunpeng; Kobayashi, Michihiro; Xiao, Shiyu; Cai, Wenjie; Barajas, Sergio; Chen, Sisi; Miao, Jinmin; Meke, Frederick Nguele; Vemula, Sasidhar; Ropa, James P; Croop, James M; Boswell, H Scott; Wan, Jun; Jia, Yuzhi; Liu, Huiping; Li, Loretta S; Altman, Jessica K; Eklund, Elizabeth A; Ji, Peng; Tong, Wei; Band, Hamid; Huang, Danny T; Platanias, Leonidas C; Zhang, Zhong-Yin; Liu, Yan.

Blood ; 141(3): 244-259, 2023 01 19.

Artigo em Inglês | MEDLINE | ID: mdl-36206490

2.

Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity.

Miao, Jinmin; Bai, Yunpeng; Miao, Yiming; Qu, Zihan; Dong, Jiajun; Zhang, Ruo-Yu; Aggarwal, Devesh; Jassim, Brenson A; Nguyen, Quyen; Zhang, Zhong-Yin.

Molecules ; 28(19)2023 Oct 06.

Artigo em Inglês | MEDLINE | ID: mdl-37836790

3.

Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy.

Dong, Jiajun; Miao, Jinmin; Miao, Yiming; Qu, Zihan; Zhang, Sheng; Zhu, Peipei; Wiede, Florian; Jassim, Brenson A; Bai, Yunpeng; Nguyen, Quyen; Lin, Jianping; Chen, Lan; Tiganis, Tony; Tao, W Andy; Zhang, Zhong-Yin.

Angew Chem Int Ed Engl ; 62(22): e202303818, 2023 05 22.

Artigo em Inglês | MEDLINE | ID: mdl-36973833

4.

Drugging Protein Tyrosine Phosphatases through Targeted Protein Degradation.

Miao, Jinmin; Zhang, Zhong-Yin.

ChemMedChem ; 19(7): e202300669, 2024 Apr 02.

Artigo em Inglês | MEDLINE | ID: mdl-38233347

5.

Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in Tp53-deficient Sarcoma and Lymphoma Mouse Models.

Nguele Meke, Frederick; Bai, Yunpeng; Ruiz-Avila, Diego; Carlock, Colin; Ayub, Jinan; Miao, Jinmin; Hu, Yanyang; Li, Qinglin; Zhang, Zhong-Yin.

Cancer Res Commun ; 4(1): 5-17, 2024 01 02.

Artigo em Inglês | MEDLINE | ID: mdl-38047587

6.

Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases.

Dong, Jiajun; Jassim, Brenson A; Milholland, Kedric L; Qu, Zihan; Bai, Yunpeng; Miao, Yiming; Miao, Jinmin; Ma, Yuan; Lin, Jianping; Hall, Mark C; Zhang, Zhong-Yin.

J Med Chem ; 2024 May 20.

Artigo em Inglês | MEDLINE | ID: mdl-38768084

7.

PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation.

Chen, Hongxia; Bai, Yunpeng; Kobayashi, Michihiro; Xiao, Shiyu; Barajas, Sergio; Cai, Wenjie; Chen, Sisi; Miao, Jinmin; Nguele Meke, Frederick; Yao, Chonghua; Yang, Yuxia; Strube, Katherine; Satchivi, Odelia; Sun, Jianmin; Rönnstrand, Lars; Croop, James M; Boswell, H Scott; Jia, Yuzhi; Liu, Huiping; Li, Loretta S; Altman, Jessica K; Eklund, Elizabeth A; Sukhanova, Madina; Ji, Peng; Tong, Wei; Band, Hamid; Huang, Danny T; Platanias, Leonidas C; Zhang, Zhong-Yin; Liu, Yan.

Mol Cancer Res ; 22(1): 94-103, 2024 Jan 02.

Artigo em Inglês | MEDLINE | ID: mdl-37756563

8.

Discovery of a selective TC-PTP degrader for cancer immunotherapy.

Miao, Jinmin; Dong, Jiajun; Miao, Yiming; Bai, Yunpeng; Qu, Zihan; Jassim, Brenson A; Huang, Bo; Nguyen, Quyen; Ma, Yuan; Murray, Allison A; Li, Jinyue; Low, Philip S; Zhang, Zhong-Yin.

Chem Sci ; 14(44): 12606-12614, 2023 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-38020389

9.

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNÎ³-cGAS-STING axis.

Wang, Xu; Yang, Chao; Wang, Xuejie; Miao, Jinmin; Chen, Weitao; Zhou, Yiren; Xu, Ying; An, Yongyan; Cheng, Aifang; Ye, Wenkang; Chen, Mengxian; Song, Dong; Yuan, Xue; Wang, Jiguang; Qian, Peiyuan; Wu, Angela Ruohao; Zhang, Zhong-Yin; Liu, Kai.

Neuron ; 111(2): 236-255.e7, 2023 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-36370710

10.

Tumor Cell-Autonomous SHP2 Contributes to Immune Suppression in Metastatic Breast Cancer.

Chen, Hao; Cresswell, Gregory M; Libring, Sarah; Ayers, Mitchell G; Miao, Jinmin; Zhang, Zhong-Yin; Solorio, Luis; Ratliff, Timothy L; Wendt, Michael K.

Cancer Res Commun ; 2(10): 1104-1118, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-36969745

11.

The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.

Gebregiworgis, Teklab; Kano, Yoshihito; St-Germain, Jonathan; Radulovich, Nikolina; Udaskin, Molly L; Mentes, Ahmet; Huang, Richard; Poon, Betty P K; He, Wenguang; Valencia-Sama, Ivette; Robinson, Claire M; Huestis, Melissa; Miao, Jinmin; Yeh, Jen Jen; Zhang, Zhong-Yin; Irwin, Meredith S; Lee, Jeffrey E; Tsao, Ming-Sound; Raught, Brian; Marshall, Christopher B; Ohh, Michael; Ikura, Mitsuhiko.

Nat Commun ; 12(1): 6274, 2021 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-34725361

12.

SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer.

Chen, Hao; Libring, Sarah; Ruddraraju, Kasi Viswanatharaju; Miao, Jinmin; Solorio, Luis; Zhang, Zhong-Yin; Wendt, Michael K.

Oncogene ; 39(49): 7166-7180, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33033382

13.

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.

Kano, Yoshihito; Gebregiworgis, Teklab; Marshall, Christopher B; Radulovich, Nikolina; Poon, Betty P K; St-Germain, Jonathan; Cook, Jonathan D; Valencia-Sama, Ivette; Grant, Benjamin M M; Herrera, Silvia Gabriela; Miao, Jinmin; Raught, Brian; Irwin, Meredith S; Lee, Jeffrey E; Yeh, Jen Jen; Zhang, Zhong-Yin; Tsao, Ming-Sound; Ikura, Mitsuhiko; Ohh, Michael.

Nat Commun ; 10(1): 224, 2019 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-30644389

14.

Copper-catalyzed aerobic dehydrogenative cyclization of N-methyl-N-phenylhydrazones: synthesis of cinnolines.

Zhang, Guangwu; Miao, Jinmin; Zhao, Yan; Ge, Haibo.

Angew Chem Int Ed Engl ; 51(33): 8318-21, 2012 Aug 13.

Artigo em Inglês | MEDLINE | ID: mdl-22782712

15.

Copper-promoted site-selective carbonylation of sp³ and sp² C-H bonds with nitromethane.

Wu, Xuesong; Miao, Jinmin; Li, Yanrong; Li, Guigen; Ge, Haibo.

Chem Sci ; 7(8): 5260-5264, 2016 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-30155175

16.

SHP2 phosphatase as a novel therapeutic target for melanoma treatment.

Zhang, Ruo-Yu; Yu, Zhi-Hong; Zeng, Lifan; Zhang, Sheng; Bai, Yunpeng; Miao, Jinmin; Chen, Lan; Xie, Jingwu; Zhang, Zhong-Yin.

Oncotarget ; 7(45): 73817-73829, 2016 Nov 08.

Artigo em Inglês | MEDLINE | ID: mdl-27650545

17.

Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp(3))-H Bonds.

Miao, Jinmin; Yang, Ke; Kurek, Martin; Ge, Haibo.

Org Lett ; 17(15): 3738-41, 2015 Aug 07.

Artigo em Inglês | MEDLINE | ID: mdl-26205696

18.

Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides.

Miao, Jinmin; Richards, Nigel G J; Ge, Haibo.

Chem Commun (Camb) ; 50(68): 9687-9, 2014 Sep 04.

Artigo em Inglês | MEDLINE | ID: mdl-25016917

19.

Palladium-catalyzed chemoselective decarboxylative ortho acylation of benzoic acids with α-oxocarboxylic acids.

Miao, Jinmin; Ge, Haibo.

Org Lett ; 15(12): 2930-3, 2013 Jun 21.

Artigo em Inglês | MEDLINE | ID: mdl-23721458

20.

Margareta Mikkelsen.

Miao, Jinmin.

Am J Med Genet A ; 120A(1): 144-54, 2003 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-12794709

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