Detalhe da pesquisa
1.
Modulation of Ligand-Gated Glycine Receptors Via Functional Monoclonal Antibodies.
J Pharmacol Exp Ther
; 383(1): 56-69, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35926871
2.
Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Nat Chem Biol
; 16(4): 391-399, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32042197
3.
Crystal structure of human glycine receptor-α3 bound to antagonist strychnine.
Nature
; 526(7572): 277-80, 2015 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416729
4.
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
Nature
; 504(7480): 437-40, 2013 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24226772
5.
Characterization of the direct interaction between KcsA-Kv1.3 and its inhibitors.
Biochim Biophys Acta
; 1848(10 Pt A): 1974-80, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26074010
6.
Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase.
Anal Biochem
; 511: 17-23, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27485270
7.
AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer.
J Pharmacol Exp Ther
; 352(2): 327-37, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25502803
8.
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Cancer Discov
; 14(2): 240-257, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37916956
9.
Deuterium kinetic isotope effects on the dissociation of a protein-fatty acid complex in the gas phase.
J Am Chem Soc
; 134(13): 5931-7, 2012 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22409493
10.
Energetics of lipid binding in a hydrophobic protein cavity.
J Am Chem Soc
; 134(6): 3054-60, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22280480
11.
Ordering of the N-terminus of human MDM2 by small molecule inhibitors.
J Am Chem Soc
; 134(41): 17059-67, 2012 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22991965
12.
NSAID-based γ-secretase modulators do not bind to the amyloid-ß polypeptide.
Biochemistry
; 50(47): 10328-42, 2011 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21995415
13.
Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells.
Clin Transl Immunology
; 10(6): e1295, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141433
14.
Evidence that water can reduce the kinetic stability of protein-hydrophobic ligand interactions.
J Am Chem Soc
; 132(50): 17658-60, 2010 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21121620
15.
Quality of alcohol-based hand disinfectants and their regulatory status. Production, sales and post-marketing surveillance.
J Hosp Infect
; 70 Suppl 1: 55-7, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18994683
16.
Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators.
Nat Struct Mol Biol
; 24(2): 108-113, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27991902
17.
The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors.
J Med Chem
; 60(3): 1105-1125, 2017 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28001399
18.
The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance.
PLoS One
; 11(9): e0163366, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27658254
19.
Discovery of Phosphodiesterase 10A (PDE10A) PET Tracer AMG 580 to Support Clinical Studies.
ACS Med Chem Lett
; 7(7): 719-23, 2016 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27437084
20.
ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis.
PLoS One
; 11(11): e0165983, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27832137