Detalhe da pesquisa
1.
Indolylazine Derivative Induces Chaperone Expression in Aged Neural Cells and Prevents the Progression of Alzheimer's Disease.
Molecules
; 27(24)2022 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36558082
2.
GAPDH-targeted therapy - A new approach for secondary damage after traumatic brain injury on rats.
Biochem Biophys Res Commun
; 501(4): 1003-1008, 2018 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29777694
3.
Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3.
Int J Mol Sci
; 19(9)2018 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30149619
4.
A hydrocortisone derivative binds to GAPDH and reduces the toxicity of extracellular polyglutamine-containing aggregates.
Biochem Biophys Res Commun
; 487(3): 723-727, 2017 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28450110
5.
Glyceraldehyde 3-phosphate dehydrogenase augments the intercellular transmission and toxicity of polyglutamine aggregates in a cell model of Huntington disease.
J Neurochem
; 136(5): 1052-63, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26662373
6.
Hsp70 chaperone rescues C6 rat glioblastoma cells from oxidative stress by sequestration of aggregating GAPDH.
Biochem Biophys Res Commun
; 470(3): 766-771, 2016 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26713364
7.
Combination of a Chaperone Synthesis Inducer and an Inhibitor of GAPDH Aggregation for Rehabilitation after Traumatic Brain Injury: A Pilot Study.
Pharmaceutics
; 15(1)2022 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36678636
8.
Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-ß Aggregation and Cytotoxicity.
Aging Dis
; 12(5): 1223-1237, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34341704
9.
Pyrrolylquinoxaline-2-One Derivative as a Potent Therapeutic Factor for Brain Trauma Rehabilitation.
Pharmaceutics
; 12(5)2020 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32366047
10.
The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers further East.
Curr Biol
; 29(10): 1701-1711.e16, 2019 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31080083
11.
Discovery and optimization of cardenolides inhibiting HSF1 activation in human colon HCT-116 cancer cells.
Oncotarget
; 9(43): 27268-27279, 2018 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29930764
12.
Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models.
Cell Death Dis
; 9(2): 41, 2018 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29348557
13.
New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease.
Exp Neurol
; 306: 199-208, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29704482
14.
Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates.
Front Neurosci
; 11: 277, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28559794
15.
Small molecules preventing GAPDH aggregation are therapeutically applicable in cell and rat models of oxidative stress.
Free Radic Biol Med
; 92: 29-38, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26748070
16.
Properties of substances inhibiting aggregation of oxidized GAPDH: Data on the interaction with the enzyme and the impact on its intracellular content.
Data Brief
; 7: 524-8, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-27054152
17.
GAPDH binders as potential drugs for the therapy of polyglutamine diseases: design of a new screening assay.
FEBS Lett
; 589(5): 581-7, 2015 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25625921