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Strain analysis of complex three-dimensional nanobridges conducted via Raman spectroscopy requires careful experimentation and data analysis supported by simulations. A method combining micro-Raman spectroscopy with finite element analysis is presented, enabling a detailed understanding of strain-sensitive Raman data measured on Si nanobridges. Power-dependent measurements are required to account for the a priori unknown scattering efficiency related to size and geometry. The experimental data is used to assess the validity of previously published phonon deformation potentials.
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PURPOSE: Several attempts to determine the transit time of a high dose rate (HDR) brachytherapy unit have been reported in the literature with controversial results. The determination of the source speed is necessary to accurately calculate the transient dose in brachytherapy treatments. In these studies, only the average speed of the source was measured as a parameter for transit dose calculation, which does not account for the realistic movement of the source, and is therefore inaccurate for numerical simulations. The purpose of this work is to report the implementation and technical design of an optical fiber based detector to directly measure the instantaneous speed profile of a 192Ir source in a Nucletron HDR brachytherapy unit. METHODS: To accomplish this task, we have developed a setup that uses the Cerenkov light induced in optical fibers as a detection signal for the radiation source moving inside the HDR catheter. As the 192Ir source travels between two optical fibers with known distance, the threshold of the induced signals are used to extract the transit time and thus the velocity. The high resolution of the detector enables the measurement of the transit time at short separation distance of the fibers, providing the instantaneous speed. RESULTS: Accurate and high resolution speed profiles of the 192Ir radiation source traveling from the safe to the end of the catheter and between dwell positions are presented. The maximum and minimum velocities of the source were found to be 52.0 +/- 1.0 and 17.3 +/- 1.2 cm/s. The authors demonstrate that the radiation source follows a uniformly accelerated linear motion with acceleration of [a] = 113 cm/s2. In addition, the authors compare the average speed measured using the optical fiber detector to those obtained in the literature, showing deviation up to 265%. CONCLUSIONS: To the best of the authors' knowledge, the authors directly measured for the first time the instantaneous speed profile of a radiation source in a HDR brachytherapy unit traveling from the unit safe to the end of the catheter and between interdwell distances. The method is feasible and accurate to implement on quality assurance tests and provides a unique database for efficient computational simulations of the transient dose.
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Braquiterapia/instrumentação , Fibras Ópticas , Radiometria/instrumentação , Fenômenos Biofísicos , Braquiterapia/estatística & dados numéricos , Humanos , Radioisótopos de Irídio/uso terapêutico , Neoplasias/radioterapia , Garantia da Qualidade dos Cuidados de SaúdeRESUMO
PURPOSE: Several studies have reported methodologies to calculate and correct the transit dose component of the moving radiation source for high dose rate (HDR) brachytherapy planning systems. However, most of these works employ the average source speed, which varies significantly with the measurement technique used, and does not represent a realistic speed profile, therefore, providing an inaccurate dose determination. In this work, the authors quantified the transit dose component of a HDR unit based on the measurement of the instantaneous source speed to produce more accurate dose values. METHODS: The Nucletron microSelectron-HDR Ir-192 source was characterized considering the Task Group 43 (TG-43U1) specifications. The transit dose component was considered through the calculation of the dose distribution using a Monte Carlo particle transport code, MCNP5, for each source position and correcting it by the source speed. The instantaneous source speed measurements were performed in a previous work using two optical fibers connected to a photomultiplier and an oscilloscope. Calculated doses were validated by comparing relative dose profiles with those obtained experimentally using radiochromic films. RESULTS: TG-43U1 source parameters were calculated to validate the Monte Carlo simulations. These agreed with the literature, with differences below 1% for the majority of the points. Calculated dose profiles without transit dose were also validated by comparison with ONCENTRA(®) Brachy v. 3.3 dose values, yielding differences within 1.5%. Dose profiles obtained with MCNP5 corrected using the instantaneous source speed profile showed differences near dwell positions of up to 800% in comparison to values corrected using the average source speed, but they are in good agreement with the experimental data, showing a maximum discrepancy of approximately 3% of the maximum dose. Near a dwell position the transit dose is about 22% of the dwell dose delivered by the source dwelling 1 s and reached 104.0 cGy per irradiation in a hypothetical clinical case studied in this work. CONCLUSIONS: The present work demonstrated that the transit dose correction based on average source speed fails to accurately correct the dose, indicating that the correct speed profile should be considered. The impact on total dose due to the transit dose correction near the dwell positions is significant and should be considered more carefully in treatments with high dose rate, several catheters, multiple dwell positions, small dwell times, and several fractions.
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Braquiterapia/métodos , Radioisótopos de Irídio/uso terapêutico , Doses de Radiação , Planejamento da Radioterapia Assistida por Computador/métodos , Dosimetria Fotográfica , Método de Monte Carlo , Dosagem Radioterapêutica , Reprodutibilidade dos TestesRESUMO
Strained Si nanowires are among the most promising transistor structures for implementation in very large-scale integration due to of their superior electrostatic control and enhanced transport properties. Realizing even higher strain levels within such nanowires are thus one of the current challenges in microelectronics. Here we achieve 4.5% of elastic strain (7.6 GPa uniaxial tensile stress) in 30 nm wide Si nanowires, which considerably exceeds the limit that can be obtained using SiGe-based virtual substrates. Our approach is based on strain accumulation mechanisms in suspended dumbbell-shaped bridges patterned on strained Si-on-insulator, and is compatible with complementary metal oxide semiconductor fabrication. Potentially, this method can be applied to any tensile prestrained layer, provided the layer can be released from the substrate, enabling the fabrication of a variety of strained semiconductors with unique properties for applications in nanoelectronics, photonics and photovoltaics. This method also opens up opportunities for research on strained materials.
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Nanotecnologia/métodos , Nanofios/química , Silício/química , Técnicas In Vitro , Resistência à TraçãoRESUMO
To assess the role of music on pain management, we examined effects of music to relieve a pain associated with a compulsory posture. Classical musics, which are recognized to make persons feel well, were chosen in this study. Five healthy adult females kept a supine position for 2 hours without music. Complains, and variations of heart beat and respiration were observed in each individual during the 2 hour experiment. After 5 days or more, these subjects had the same experience with music. Frequency and intensity of complains were significantly diminished by music. Heart rate was not changed by music. Respiration rate was increased in 3 subjects with music. Frequency of irregular respiration was significantly decreased by music. There was a positive correlation between frequency of irregular respiration and number of complaints in subjects kept without music. The present study demonstrated that music is effective to relieve a pain associated with a compulsory posture. Our results suggest that music plays a significant role on pain management in palliative therapy.