Detalhe da pesquisa
1.
CRISPR-Cas9n-mediated ELANE promoter editing for gene therapy of severe congenital neutropenia.
Mol Ther
; 2024 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38556793
2.
Design of novel granulopoietic proteins by topological rescaffolding.
PLoS Biol
; 18(12): e3000919, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33351791
3.
CRISPR/Cas9-mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients.
Haematologica
; 105(3): 598-609, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31248972
4.
GM-CSF treatment is not effective in congenital neutropenia patients due to its inability to activate NAMPT signaling.
Ann Hematol
; 96(3): 345-353, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27966038
5.
A topological refactoring design strategy yields highly stable granulopoietic proteins.
Nat Commun
; 13(1): 2948, 2022 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35618709
6.
NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells.
Stem Cell Res Ther
; 12(1): 112, 2021 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33546767
7.
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia.
Cell Stem Cell
; 28(5): 906-922.e6, 2021 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33894142
8.
Gene Knockout in Hematopoietic Stem and Progenitor Cells Followed by Granulocytic Differentiation.
Methods Mol Biol
; 2115: 455-469, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32006417
9.
New insights into the pathomechanism of cyclic neutropenia.
Ann N Y Acad Sci
; 1466(1): 83-92, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32083314
10.
Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response.
Blood Adv
; 3(1): 63-71, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30622144
11.
Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34+ cells preceding leukemic transformation.
Exp Hematol
; 71: 51-60, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30615903
12.
Correction: NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells.
Stem Cell Res Ther
; 14(1): 299, 2023 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37858174
13.
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia.
Cell Stem Cell
; 30(9): 1282, 2023 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37683606
14.
Corrigendum to 'Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34+ cells preceding leukemic transformation' <[Experimental Hematology, Volume 71, 2019;71:51-60]>.
Exp Hematol
; 114: 61, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35952718
15.
Molecular and functional interactions between AKT and SOX2 in breast carcinoma.
Oncotarget
; 6(41): 43540-56, 2015 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26498353