1.
J Org Chem
; 88(15): 11367-11371, 2023 Aug 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37466434
RESUMO
Solid-phase total synthesis of nannocystin Ax (1) was disclosed. A coupling reaction between a peptide and a polyketide moiety was conducted on a solid support, and macrocyclization was achieved by Mitsunobu cyclization. The established synthetic route was efficient to prepare its analogues, which contain different types of peptide moieties.