Detalhe da pesquisa
1.
Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver.
Drug Metab Dispos
; 48(10): 934-943, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32665417
2.
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.
Nat Chem Biol
; 9(2): 112-8, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23222885
3.
Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet-fed chimeric mice with hepatocyte-humanized livers.
Mol Ther Methods Clin Dev
; 31: 101165, 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38144682
4.
Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases.
Nat Biotechnol
; 41(4): 500-512, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36424489
5.
Simultaneous measurement of mouse and human albumin in chimeric mice with humanized livers.
Bioanalysis
; 14(5): 267-278, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35195037
6.
Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.
Biochemistry
; 50(33): 7146-56, 2011 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21755988
7.
Facilitating Akt clearance via manipulation of Hsp70 activity and levels.
J Biol Chem
; 285(4): 2498-505, 2010 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19889640
8.
Hsc70 rapidly engages tau after microtubule destabilization.
J Biol Chem
; 285(22): 16798-805, 2010 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20308058
9.
Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum.
Bioorg Med Chem
; 19(22): 6608-14, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21737286
10.
Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse Model.
Cell Mol Gastroenterol Hepatol
; 11(1): 185-198, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-32861832
11.
Chemical manipulation of hsp70 ATPase activity regulates tau stability.
J Neurosci
; 29(39): 12079-88, 2009 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-19793966
12.
Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.
J Med Chem
; 61(12): 5162-5186, 2018 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29727569
13.
Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease.
Spine J
; 14(6): 1017-28, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24291703
14.
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.
ACS Chem Neurosci
; 4(6): 930-9, 2013 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23472668
15.
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.
Biol Psychiatry
; 74(5): 367-74, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23607970
16.
Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70.
Chem Biol
; 19(11): 1391-9, 2012 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23177194
17.
A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication.
Antiviral Res
; 96(1): 70-81, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22898086
18.
Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance.
PLoS One
; 7(4): e35566, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22563386
19.
Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.
Future Med Chem
; 3(12): 1523-37, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21882945
20.
Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones.
J Mol Biol
; 411(3): 614-32, 2011 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21708173