Detalhe da pesquisa
1.
Design, synthesis, structure-activity relationship studies, and evaluation of novel GLS1 inhibitors.
Bioorg Med Chem Lett
; 87: 129266, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37011768
2.
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity.
Bioorg Med Chem Lett
; 93: 129438, 2023 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37549852
3.
Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis.
Bioorg Med Chem
; 90: 117370, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37311373
4.
Combinatorial screening for therapeutics in ATTRv amyloidosis identifies naphthoquinone analogues as TTR-selective amyloid disruptors.
J Pharmacol Sci
; 151(1): 54-62, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36522123
5.
The hydrophobic residue Leu73 is crucial for the high stability and low aggregation properties of murine transthyretin.
Biochem J
; 479(18): 1999-2011, 2022 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36098398
6.
Determination of Hardness of a Pharmaceutical Oral Jelly by Using T2 Relaxation Behavior Measured by Time-Domain NMR.
Chem Pharm Bull (Tokyo)
; 70(8): 558-565, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35908922
7.
A low amyloidogenic E61K transthyretin mutation may cause familial amyloid polyneuropathy.
J Neurochem
; 156(6): 957-966, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32852783
8.
Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin-related transcription factor-B, negatively regulates dendritic complexity in cortical neurons.
J Neurochem
; 159(4): 762-777, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32639614
9.
Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis.
Bioorg Med Chem
; 44: 116292, 2021 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34225167
10.
A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH.
J Biol Chem
; 294(29): 11259-11275, 2019 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31167790
11.
The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity.
Am J Pathol
; 189(2): 308-319, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30414409
12.
Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions from Juglans mandshurica Maxim. var. cordiformis (Makino) Kitam.
Molecules
; 24(3)2019 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30704121
13.
Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase.
Bioorg Med Chem Lett
; 28(3): 441-445, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29277459
14.
Inhibition of the Amyloidogenesis of Transthyretin by Natural Products and Synthetic Compounds.
Biol Pharm Bull
; 41(7): 979-984, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29962408
15.
A novel serine racemase inhibitor suppresses neuronal over-activation in vivo.
Bioorg Med Chem
; 25(14): 3736-3745, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28533113
16.
Rifampicin is a candidate preventive medicine against amyloid-ß and tau oligomers.
Brain
; 139(Pt 5): 1568-86, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27020329
17.
Exogenous amyloidogenic proteins function as seeds in amyloid ß-protein aggregation.
Biochim Biophys Acta
; 1842(4): 646-53, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24440525
18.
Interaction between tachyplesin I, an antimicrobial peptide derived from horseshoe crab, and lipopolysaccharide.
Biochim Biophys Acta
; 1844(3): 527-34, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24389234
19.
Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity.
J Neurochem
; 134(5): 943-55, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26016728
20.
Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione.
J Pharmacol Sci
; 129(4): 240-3, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26639444