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1.
Nano Lett ; 11(7): 2875-80, 2011 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-21627099

RESUMO

For advanced electronic, optoelectronic, or mechanical nanoscale devices a detailed understanding of their structural properties and in particular the strain state within their active region is of utmost importance. We demonstrate that X-ray nanodiffraction represents an excellent tool to investigate the internal structure of such devices in a nondestructive way by using a focused synchotron X-ray beam with a diameter of 400 nm. We show results on the strain fields in and around a single SiGe island, which serves as stressor for the Si-channel in a fully functioning Si-metal-oxide semiconductor field-effect transistor.


Assuntos
Germânio/química , Nanotecnologia , Pontos Quânticos , Silício/química , Transistores Eletrônicos , Tamanho da Partícula , Semicondutores , Propriedades de Superfície , Raios X
2.
Biosens Bioelectron ; 21(7): 1037-44, 2006 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-16029948

RESUMO

A field-effect transistor (FET) for recording extracellular signals from electrogenic cells is presented. The so-called floating gate architecture combines a complementary metal oxide semiconductor (CMOS)-type n-channel transistor with an independent sensing area. This concept allows the transistor and sensing area to be optimised separately. The devices are robust and can be reused several times. The noise level of the devices was smaller than of comparable non-metallised gate FETs. In addition to the usual drift of FET devices, we observed a long-term drift that has to be controlled for future long-term measurements. The device performance for extracellular signal recording was tested using embryonic rat cardiac myocytes cultured on fibronectin-coated chips. The extracellular cell signals were recorded before and after the addition of the cardioactive isoproterenol. The signal shapes of the measured action potentials were comparable to the non-metallised gate FETs previously used in similar experiments. The fabrication of the devices involved the process steps of standard CMOS that were necessary to create n-channel transistors. The implementation of a complete CMOS process would facilitate the integration of the logical circuits necessary for signal pre-processing on a chip, which is a prerequisite for a greater number of sensor spots in future layouts.


Assuntos
Potenciais de Ação/fisiologia , Amplificadores Eletrônicos , Técnicas Biossensoriais/instrumentação , Potenciais da Membrana/fisiologia , Microeletrodos , Miócitos Cardíacos/fisiologia , Transistores Eletrônicos , Animais , Células Cultivadas , Desenho de Equipamento , Análise de Falha de Equipamento , Ratos , Ratos Wistar , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
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