Detalhe da pesquisa
1.
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.
Cell
; 141(7): 1146-58, 2010 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20541250
2.
Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-ßCTF (C99).
J Neurosci
; 39(27): 5255-5268, 2019 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31043483
3.
Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice.
Hum Mol Genet
; 26(5): 843-859, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28062666
4.
Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome.
Neurobiol Dis
; 120: 165-173, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30176349
5.
G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain.
Neurobiol Dis
; 54: 475-85, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23396011
6.
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.
Brain
; 134(Pt 1): 258-77, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21186265
7.
Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons.
Cell Rep
; 35(4): 109034, 2021 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33910020
8.
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
J Cell Biol
; 171(1): 87-98, 2005 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16203860
9.
ß2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7.
J Mol Biol
; 432(8): 2633-2650, 2020 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32105735
10.
Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.
J Neurosci
; 28(47): 12241-54, 2008 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19020018
11.
Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density.
J Cell Biol
; 159(2): 279-90, 2002 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-12403814
12.
Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy.
Autophagy
; 12(12): 2467-2483, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27813694
13.
The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons.
PLoS One
; 6(2): e17087, 2011 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21359212
14.
Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.
Autophagy
; 7(7): 788-9, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21464620