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Neuroimage ; 243: 118498, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34428572

RESUMO

Despite significant interest in the neural underpinnings of behavioral variability, little light has been shed on the cortical mechanism underlying the failure to respond to perceptual-level stimuli. We hypothesized that cortical activity resulting from perceptual-level stimuli is sensitive to the moment-to-moment fluctuations in cortical excitability, and thus may not suffice to produce a behavioral response. We tested this hypothesis using electrocorticographic recordings to follow the propagation of cortical activity in six human subjects that responded to perceptual-level auditory stimuli. Here we show that for presentations that did not result in a behavioral response, the likelihood of cortical activity decreased from auditory cortex to motor cortex, and was related to reduced local cortical excitability. Cortical excitability was quantified using instantaneous voltage during a short window prior to cortical activity onset. Therefore, when humans are presented with an auditory stimulus close to perceptual-level threshold, moment-by-moment fluctuations in cortical excitability determine whether cortical responses to sensory stimulation successfully connect auditory input to a resultant behavioral response.


Assuntos
Excitabilidade Cortical/fisiologia , Estimulação Acústica , Adulto , Idoso , Ritmo alfa/fisiologia , Córtex Auditivo/fisiologia , Mapeamento Encefálico/métodos , Eletrocorticografia/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
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