Detalhe da pesquisa
1.
Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core.
Bioorg Med Chem
; 52: 116528, 2021 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34839158
2.
Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.
Eur J Nucl Med Mol Imaging
; 46(10): 2178-2189, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31264169
3.
The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases.
Nat Commun
; 14(1): 6750, 2023 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37891183
4.
Acidic triazoles as soluble guanylate cyclase stimulators.
Bioorg Med Chem Lett
; 21(21): 6515-8, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21924901
5.
PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer's Disease and Other Tauopathies.
J Med Chem
; 64(17): 12808-12830, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34455780
6.
Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies.
Eur J Med Chem
; 204: 112615, 2020 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32771872
7.
Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.
ACS Med Chem Lett
; 4(11): 1037-41, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900603