Detalhe da pesquisa
1.
Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine.
Bioorg Med Chem Lett
; 26(13): 3202-3206, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27080178
2.
Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine.
Bioorg Med Chem Lett
; 26(13): 3207-3211, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27038498
3.
Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors.
Bioorg Med Chem Lett
; 19(7): 2048-52, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19249203
4.
Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.
Bioorg Med Chem Lett
; 19(15): 4070-4, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19577469
5.
Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.
Bioorg Med Chem Lett
; 19(11): 3050-3, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19394219
6.
Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.
Bioorg Med Chem
; 16(3): 1345-58, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17998165
7.
Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.
Br J Pharmacol
; 175(12): 2470-2482, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29582428
8.
A rat pharmacokinetic/pharmacodynamic model for assessment of lipopolysaccharide-induced tumor necrosis factor-alpha production.
J Pharmacol Toxicol Methods
; 56(1): 67-71, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17391989
9.
The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations.
Br J Pharmacol
; 173(21): 3088-3098, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27449698
10.
Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties.
J Med Chem
; 59(19): 9005-9017, 2016 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27690427
11.
"Blue heart": characterization of a mifepristone-dependent system for conditional gene expression in genetically modified animals.
Biochim Biophys Acta
; 1627(1): 15-25, 2003 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12759188
12.
The cPLA2α inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid.
Neuropharmacology
; 60(4): 633-41, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21146550
13.
Sensitive and cost-effective LC-MS/MS method for quantitation of CVT-6883 in human urine using sodium dodecylbenzenesulfonate additive to eliminate adsorptive losses.
J Chromatogr B Analyt Technol Biomed Life Sci
; 877(10): 943-7, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19282253
14.
In vitro-in vivo correlation on delivery of drug candidates to articular cartilage.
Pharm Res
; 25(7): 1641-6, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18324355
15.
In vitro interactions between a potential muscle relaxant E2101 and human cytochromes P450.
Drug Metab Dispos
; 30(7): 805-13, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12065439