Detalhe da pesquisa
1.
Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.
Brain
; 145(12): 4349-4367, 2022 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36074904
2.
Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
Bioorg Med Chem Lett
; 30(3): 126751, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31862412
3.
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.
Pharmacol Rev
; 65(3): 967-86, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23686350
4.
Development of a High-Throughput Screening Assay for Small-Molecule Inhibitors of Androgen Receptor Splice Variants.
Assay Drug Dev Technol
; 20(3): 111-124, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35333596
5.
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.
J Med Chem
; 65(1): 562-578, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34939789
6.
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
J Med Chem
; 65(10): 7212-7230, 2022 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35536179
7.
Structural Insights into Notum Covalent Inhibition.
J Med Chem
; 64(15): 11354-11363, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34292747
8.
Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila.
Elife
; 102021 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33739284
9.
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.
J Med Chem
; 63(21): 12942-12956, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33124429
10.
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
J Med Chem
; 63(17): 9464-9483, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787107
11.
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
Medchemcomm
; 10(8): 1361-1369, 2019 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31534655
12.
A sting in the tail: the N-terminal domain of the androgen receptor as a drug target.
Asian J Androl
; 18(5): 687-94, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27212126