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Nat Methods ; 19(2): 242-254, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-35145319

RESUMO

Despite advances in imaging, image-based vascular systems biology has remained challenging because blood vessel data are often available only from a single modality or at a given spatial scale, and cross-modality data are difficult to integrate. Therefore, there is an exigent need for a multimodality pipeline that enables ex vivo vascular imaging with magnetic resonance imaging, computed tomography and optical microscopy of the same sample, while permitting imaging with complementary contrast mechanisms from the whole-organ to endothelial cell spatial scales. To achieve this, we developed 'VascuViz'-an easy-to-use method for simultaneous three-dimensional imaging and visualization of the vascular microenvironment using magnetic resonance imaging, computed tomography and optical microscopy in the same intact, unsectioned tissue. The VascuViz workflow permits multimodal imaging with a single labeling step using commercial reagents and is compatible with diverse tissue types and protocols. VascuViz's interdisciplinary utility in conjunction with new data visualization approaches opens up new vistas in image-based vascular systems biology.


Assuntos
Encéfalo/irrigação sanguínea , Imagem Multimodal/métodos , Biologia de Sistemas/métodos , Animais , Encéfalo/diagnóstico por imagem , Neoplasias da Mama/diagnóstico por imagem , Circulação Cerebrovascular , Meios de Contraste , Visualização de Dados , Feminino , Hemodinâmica , Humanos , Imageamento Tridimensional/métodos , Imageamento por Ressonância Magnética , Masculino , Camundongos Endogâmicos , Tomografia Computadorizada por Raios X , Fluxo de Trabalho
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