A tale of 141 municipalities: the spatial distribution of dengue in Mato Grosso, Brazil.

BACKGROUND: In recent years, the state of Mato Grosso has presented one of the highest dengue incidence rates in Brazil. The meeting of the Amazon, Cerrado and Pantanal biomes results in a large variation of rainfall and temperature across different regions of the state. In addition, Mato Grosso has been undergoing intense urban growth since the 1970s, mainly due to the colonization of the Mid-North and North regions. We analyzed factors involved in dengue incidence in Mato Grosso from 2008 to 2019. METHODS: The Moran Global Index was used to assess spatial autocorrelation of dengue incidence using explanatory variables such as temperature, precipitation, deforestation, population density and municipal development index. Areas at risk of dengue were grouped by the Local Moran Indicator. RESULTS: We noticed that areas at risk of dengue expanded from the Mid-North region to the North; the same pattern occurred from the Southeast to the Northeast; the South region remained at low-risk levels. The increase in incidence was influenced by precipitation, deforestation and the municipal development index. CONCLUSIONS: The identification of risk areas for dengue in space and time enables public health authorities to focus their control and prevention efforts, reducing infestation and the potential impact of dengue in the human population.

Microbiome and oral squamous cell carcinoma: a possible interplay on iron metabolism and its impact on tumor microenvironment.

There is increasing evidence showing positive association between changes in oral microbiome and the occurrence of oral squamous cell carcinoma (OSCC). Alcohol- and nicotine-related products can induce microbial changes but are still unknown if these changes are related to cancerous lesion sites. In an attempt to understand how these changes can influence the OSCC development and maintenance, the aim of this study was to investigate the oral microbiome linked with OSCC as well as to identify functional signatures and associate them with healthy or precancerous and cancerous sites. Our group used data of oral microbiomes available in public repositories. The analysis included data of oral microbiomes from electronic cigarette users, alcohol consumers, and precancerous and OSCC samples. An R-based pipeline was used for taxonomic and functional prediction analysis. The Streptococcus spp. genus was the main class identified in the healthy group. Haemophilus spp. predominated in precancerous lesions. OSCC samples revealed a higher relative abundance compared with the other groups, represented by an increased proportion of Fusobacterium spp., Prevotella spp., Haemophilus spp., and Campylobacter spp. Venn diagram analysis showed 52 genera exclusive of OSCC samples. Both precancerous and OSCC samples seemed to present a specific associated functional pattern. They were menaquinone-dependent protoporphyrinogen oxidase pattern enhanced in the former and both 3',5'-cyclic-nucleotide phosphodiesterase (purine metabolism) and iron(III) transport system ATP-binding protein enhanced in the latter. We conclude that although precancerous and OSCC samples present some differences on microbial profile, both microbiomes act as "iron chelators-like" potentially contributing to tumor growth.

Efeito de polímeros naturais na conservação de banana CV Caturra / Effect of natural polymers in banana CV caturra conservation

Este trabalho teve como objetivo avaliar o efeito de filmes formados por pectina, albúmen de ovo, carragena, gelatina, fécula de batata, xantana e amido de milho na conservação de banana cv. Caturra. As bananas foram sanitizadas e imersas em soluções filmogênicas de pectina (2%), albúmen de ovo (100%), carragena (2%), gelatina (5%), fécula de batata (2%) com glicerol (0,7%), xantana (1%), amido de milho (2%) com glicerol (0,7%) e o controle (0%), sendo armazenadas a 18ºC a 80% de UR por 8 dias. As bananas revestidas foram avaliados de acordo com a perda de massa, taxa de perda de massa, sólidos solúveis totais, cor (luminosidade e croma b*) e firmeza, nos tempos de zero hora, 2, 6, 7 e 8 dias. Ao final do período de armazenamento as bananas cv Caturra revestidas com filmes de pectina promoveram menor perda de massa e se mantiveram dentro do limite permitido (7%) até os 4,9 dias. O revestimento com carragena mostrou menor aumento dos sólidos solúveis totais, já os filmes de albúmen proporcionaram menores reduções da firmeza e variações da coloração amarela e o revestimento com fécula de batata melhorou a luminosidade nos frutos. Este aspecto mostra uma contribuição dos filmes na manutenção da qualidade da banana cv. Caturra. No entanto, outros parâmetros de qualidade devem ser avaliados, buscando conhecer outros efeitos desses filmes sobre a banana.