Detalhe da pesquisa
1.
Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site.
Bioorg Med Chem
; 82: 117217, 2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36889150
2.
Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents.
Molecules
; 27(1)2022 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35011550
3.
Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA.
Mol Pharmacol
; 100(4): 309-318, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34312217
4.
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Bioorg Med Chem
; 35: 116061, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33647840
5.
The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity.
Bioorg Med Chem
; 29: 115887, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33310545
6.
An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures.
J Nat Prod
; 84(3): 750-761, 2021 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33226219
7.
Leucinostatins from Ophiocordyceps spp. and Purpureocillium spp. Demonstrate Selective Antiproliferative Effects in Cells Representing the Luminal Androgen Receptor Subtype of Triple Negative Breast Cancer.
J Nat Prod
; 83(6): 2010-2024, 2020 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32510949
8.
Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea.
J Nat Prod
; 83(7): 2269-2280, 2020 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32649211
9.
Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of Choerospondias axillaris.
J Nat Prod
; 83(3): 584-592, 2020 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32105068
10.
CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells.
J Nat Prod
; 83(10): 3080-3092, 2020 10 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33021790
11.
Eribulin rapidly inhibits TGF-ß-induced Snail expression and can induce Slug expression in a Smad4-dependent manner.
Br J Cancer
; 121(7): 611-621, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31481735
12.
Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype.
Breast Cancer Res Treat
; 177(2): 345-355, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31230251
13.
Microtubule-Targeting Drugs: More than Antimitotics.
J Nat Prod
; 82(3): 680-685, 2019 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30835122
14.
In Situ Ring Contraction and Transformation of the Rhizoxin Macrocycle through an Abiotic Pathway.
J Nat Prod
; 82(4): 886-894, 2019 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30865445
15.
Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines.
J Nat Prod
; 82(4): 928-936, 2019 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30830773
16.
Identification of C-6 as a New Site for Linker Conjugation to the Taccalonolide Microtubule Stabilizers.
J Nat Prod
; 82(3): 583-588, 2019 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30799622
17.
Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.
Int J Mol Sci
; 20(6)2019 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30897704
18.
Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential.
Bioorg Med Chem Lett
; 28(18): 3085-3093, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30098869
19.
Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent.
Bioorg Med Chem
; 26(9): 2437-2451, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29655610
20.
Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents.
Bioorg Med Chem
; 26(20): 5470-5478, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30297118