Detalhe da pesquisa
1.
Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles.
Nat Chem Biol
; 16(5): 497-506, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32231343
2.
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Proc Natl Acad Sci U S A
; 116(7): 2551-2560, 2019 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30683722
3.
Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.
J Biol Chem
; 289(13): 9304-19, 2014 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24497639
4.
Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162.
Acta Crystallogr D Struct Biol
; 77(Pt 2): 237-248, 2021 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33559612
5.
BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies.
J Med Chem
; 64(17): 12723-12737, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34428039
6.
Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C.
ChemMedChem
; 15(10): 827-832, 2020 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32237114
7.
Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models.
J Med Chem
; 63(13): 7293-7325, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32502336
8.
The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models.
Mol Cancer Ther
; 19(1): 26-38, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31582533
9.
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia.
Nat Commun
; 11(1): 2992, 2020 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32532974
10.
Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
J Med Chem
; 62(2): 928-940, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30563338
11.
Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo.
J Med Chem
; 62(22): 10321-10341, 2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31670515
12.
Bispecific antibody pretargeting of tumor neovasculature for improved systemic radiotherapy of solid tumors.
Clin Cancer Res
; 12(18): 5587-95, 2006 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17000696
13.
Imaging of tumor angiogenesis using 99mTc-labeled human recombinant anti-ED-B fibronectin antibody fragments.
J Nucl Med
; 47(10): 1707-16, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17015908
14.
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
J Med Chem
; 59(3): 1176-83, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26824386
15.
TNF-Selectokine: a novel prodrug generated for tumor targeting and site-specific activation of tumor necrosis factor.
Oncogene
; 21(27): 4257-65, 2002 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12082613
16.
Cell-based protein stabilization assays for the detection of interactions between small-molecule inhibitors and BRD4.
J Biomol Screen
; 20(2): 180-9, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25266565
17.
Fab MOR03268 triggers absorption shift of a diagnostic dye via packaging in a solvent-shielded Fab dimer interface.
J Mol Biol
; 377(1): 206-19, 2008 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18241888