Controlled ovarian stimulation in cancer patients under 18 years old; a case series.

BACKGROUND: Fertility preservation for adolescent pubescent girls is a concern of the healthcare system and parents. Oocyte cryopreservation is regarded as a standard medical intervention for patients with a minimum age of 18 years. Evidence suggests that mature oocyte cryopreservation is possible for adolescent pubescent girls, although, ovarian stimulation for these patients remains a challenge. CASES PRESENTATION: This case series is the first report regarding ovarian stimulation with oocyte cryopreservation in younger than 18 years cancerous girls, who refer to ROYAN institute, Tehran, Iran, prior to the start of the treatment of cancer (November 2015 to February 2021). The oocyte cryopreservation was carried out in the 7 patients (five patients with Hodgkin lymphoma, one patient with Ewing sarcoma, and one patient with osteogenic tumor), the embryo cryopreservation in one patient with dysgerminoma, and the oocyte and embryo cryopreservation in one patient with germ cell tumor. No oocytes were retrieved after ovarian stimulation in the patient with medulloblastoma. For one of the patients with Hodgkin lymphoma, half of the tissues of one ovary were cryopreserved prior to ovarian stimulation. CONCLUSIONS: Oocyte cryopreservation is a feasible option of fertility preservation in the adolescent's patients with cancer. However, only if reported acceptable fertilization rates, as well as the successful cases of live birth from oocyte cryopreservation at the ages under 18, this option of preserving fertility can be applied to this age range.

Obtention of 74:26 polyester/cellulose fabric blend with super-hydrophobic and super-hydrophilic properties by air corona discharge treatment and their characterization.

A facile method was used to create both of the super-hydrophilic and super-hydrophobic properties on polyester/cellulose fabric blend. The fabric was exposed to air corona discharge treatment without any extra chemical modification. The static contact angle of 0° and 167° was indicated for super-hydrophilic and super-hydrophobic samples, respectively. The decrease of intensity of active functional groups and the increase of roughness with a nano-scale pattern presented a super-hydrophobic surface that confirmed by ATR-FTIR, AFM and FESEM analysis. This is while the increase of intensity of the active functional groups and the surface roughness with a micro-scale pattern was shown for the super-hydrophilic sample. The wettability tests show the enhancement of hydrophobic and hydrophilic properties for 300 W-10 min and 800 W-10 min corona discharge treated samples, respectively. Therefore, there is a critical point of the corona discharge process that enables it to create hydrophobic and/or hydrophilic properties on the substrates.