Synthesis of Contorted Polycyclic Aromatic Compounds via Alkyne Benzannulation on Zigzag-Edged Dibenzochrysene Derivatives.

Organic dyes are interesting building blocks for the preparation of organic semiconductors as they possess synthetic handles that can be used to functionalize them and, consequently, change their electronic properties. However, reactions to extend their π-conjugated framework through ring annulation have only been scarcely tested. Herein, we report the use of alkyne benzannulation on 2,8-dibromo-dibenzo[def,mno]chrysene (vat orange 3) and 2,9-dibromo-dibenzo[b,def]chrysene (vat orange 1) to extend the conjugation and reduce their bandgap. Unexpectedly, the ring closure reaction takes place at the most sterically hindered positions (peri to the substituent) to yield contorted polycyclic compounds. More surprisingly, both TIPS-acetylene-functionalized derivatives underwent a tandem dearomative spirocyclization to form bent polycyclic compounds. Absorption spectroscopy reveals that ring annulation on both 2,9-dibromo-dibenzo[b,def]chrysene and 2,8-dibromo-dibenzo[def,mno]chrysene resulted in a decrease of 0.38 and 0.12 eV in bandgap values, respectively, despite inducing a contorted conformation.

Mechanical and metabolic power in accelerated running-Part II: team sports.

PURPOSE: This manuscript is devoted to discuss the interplay between velocity and acceleration in setting metabolic and mechanical power in team sports. METHODS: To this aim, an essential step is to assess the individual Acceleration-Speed Profile (ASP) by appropriately analysing training sessions or matches. This allows one to estimate maximal mechanical and metabolic power, including that for running at constant speed, and hence to determine individual thresholds thereof. RESULTS: Several approaches are described and the results, as obtained from 38 official matches of one team (Italian Serie B, season 2020-2021), are reported and discussed. The number of events in which the external mechanical power exceeded 80% of that estimated from the subject's ASP ([Formula: see text]) was 1.61 times larger than the number of accelerations above 2.5 m s-2 ([Formula: see text]). The difference was largest for midfielders and smallest for attackers (2.30 and 1.36 times, respectively) due to (i) a higher starting velocity for midfielders and (ii) a higher external peak power for attackers in performing [Formula: see text]. From the energetic perspective, the duration and the corresponding metabolic power of high-demanding phases ([Formula: see text]) were essentially constant (6 s and 22 W  kg-1, respectively) from the beginning to the end of the match, even if their number decreased from 28 in the first to 21 in the last 15-min period, as a consequence of the increased recovery time between [Formula: see text] from 26 s in the first to 37 s in the last 15-min period. CONCLUSION: These data underline the flaws of acceleration counting above fixed thresholds.

Human foot muscle strength and its association with sprint acceleration, cutting and jumping performance, and kinetics in high-level athletes.

The primary objective of this study was to investigate the relationship between metatarsophalangeal joint (MTPj) flexion torque and sprint acceleration, cutting and jumping performance, and kinetics. A secondary aim was to explore this relationship when MTP flexion strength was associated with other foot and lower limb neuromuscular outputs. After an initial MTPj flexion torque assessment using a custom-built dynamometer, 52 high-level athletes performed the following tasks on a force platform system: maximal sprint acceleration, 90-degree cutting, vertical and horizontal jumps, and foot-ankle hops. Their foot posture, foot passive stiffness and foot-ankle reactive strength were assessed using the Foot Posture Index, the Arch Height Index Measurement System and the Foot-Ankle Rebound Jump Test. Ankle plantarflexion and knee extension isometric torque were assessed using an isokinetic dynamometer. During maximal speed sprinting, multiple linear regressions suggested a major contribution of MTPj flexion torque, foot passive stiffness and foot-ankle reactive strength to explain 28% and 35% of the total variance in the effective vertical impulse and contact time. Ankle plantarflexor and quadriceps isometric torques were aggregately contributors of acceleration performance and separate contributors of cutting and jumping performance. In conclusion, MTPj flexion torque was more strongly associated with sprinting performance kinetics especially at high-speed.

Submaximal force-velocity relationships during mountain ultramarathon: Data from the field.

This study presents a novel method for evaluating the submaximal velocity-force (V(F)) relationship in mountain ultramarathon races using crowdsourced data from Strava.com. The dataset includes positional data from 408 participants of the 171-km UTMB® 2023 race (9,850-m D+). The race was divided into 100-m segments. The mean net propulsive force and velocity were computed for each segment to describe the submaximal V(F) relationship as a rational function of three parameters. F1: propulsive force at 1 m · s-1; V0: theoretical maximum velocity on flat terrain; C: curvature parameter (the lower C, the more linear the V(F) relationship). The V(F) profile parameters were found to be F1 = 1.80 ± 0.33 N · kg-1, V0 = 2.36 ± 0.42 m · s-1, and C = 0.66 ± 1.81, with good independence between the parameters within a group of homogeneous performance. The best athletes had the highest F1, V0, and C values. V(F) parameters were affected by fatigue during the race, with decreases of 20.9%, 32.0%, and 59.8% between the first and second parts of the race respectively. These findings suggest that the V(F) relationship is an interesting original approach for studying performance and fatigability during mountain ultra-endurance races.

π-Extended 4,5-Fused Bis-Fluorene: Highly Open-Shell Compounds and their Cationic Tetrathiafulvalene Derivatives.

The synthesis of diradical organic compounds has garnered significant attention due to their thermally accessible spin inversion and optoelectronic properties. Yet, preparing such stable structures with high open-shell behavior remains challenging. Herein, we report the synthesis and properties of four π-extended, fused fluorene derivatives with high diradical character, taking advantage of a molecular design where the closed-shell does not include any Clar sextet, comparatively to a maximum of 5 in the corresponding open-shell state. This led to an unusual open-shell triplet ground state with an outstanding singlet-triplet energy difference (ΔEST) of ca. 19 kcal/mol, one of the highest values reported to date for an all-carbon conjugated scaffold. Incorporation of dithiafulvene units at each end of the molecule (at the five-membered rings) furnishes extended tetrathiafulvalenes (TTFs) undergoing reversible oxidations to the radical cation and diradical dication. The various pro-aromatic structures presented herein show highly localized spin density and a limited conjugation due to the confined π-electrons in the aromatic cycles, as supported by 1H NMR, UV/Visible, EPR spectroscopy and DFT calculations.

Circadian modulation of microglial physiological processes and immune responses.

Microglia is considered the central nervous system (CNS) resident macrophages that establish an innate immune response against pathogens and toxins. However, the recent studies have shown that microglial gene and protein expression follows a circadian pattern; several immune activation markers and clock genes are expressed rhythmically without the need for an immune stimulus. Furthermore, microglia responds to an immune challenge with different magnitudes depending on the time of the day. This review examines the circadian control of microglia function and the possible physiological implications. For example, we discuss that synaptic prune is performed in the cortex at a certain moment of the day. We also consider the implications of daily microglial function for maintaining biological rhythms like general activity, body temperature, and food intake. We conclude that the developmental stage, brain region, and pathological state are not the only factors to consider for the evaluation of microglial functions; instead, emerging evidence indicates that circadian time as an essential aspect for a better understanding of the role of microglia in CNS physiology.

Anticoagulation strategy and safety in critically ill COVID-19 patients: a French retrospective multicentre study.

BACKGROUND: Patients with critical illness due to COVID-19 exhibit increased coagulability associated with a high risk of venous thrombo-embolism (VTE). Data on prophylactic anticoagulation for these patients are limited and conflicting. The purpose of this study was to evaluate whether intermediate-dose prophylactic anticoagulation in patients with COVID-19 requiring ICU admission was associated with better outcomes compared to standard-dose prophylactic anticoagulation. METHODS: We retrospectively included adults admitted with severe COVID-19 to any of 15 ICUs, in 2020 or 2021. We compared the groups given intermediate-dose vs. standard-dose prophylactic anticoagulation. The primary outcome was all-cause day-90 mortality. Secondary outcomes were VTE (pulmonary embolism or deep vein thrombosis), ICU stay length, and adverse effects of anticoagulation. RESULTS: Of 1174 included patients (mean age, 63 years), 399 received standard-dose and 775 intermediate-dose prophylactic anticoagulation. Of the 211 patients who died within 90 days, 86 (21%) received intermediate and 125 (16%) standard doses. After adjustment on early corticosteroid therapy and critical illness severity, there were no significant between-group differences in day-90 mortality (hazard ratio [HR], 0.73; 95%CI, 0.52-1.04; p = 0.09) or ICU stay length (HR, 0.93; 95%CI, 0.79-1.10; p = 0.38). Intermediate-dose anticoagulation was significantly associated with fewer VTE events (HR, 0.55; 95%CI, 0.38-0.80; p < 0.001). Bleeding events occurred in similar proportions of patients in the two groups (odds ratio, 0.86; 95%CI, 0.50-1.47; p = 0.57). CONCLUSIONS: Mortality on day 90 did not differ between the groups given standard-dose and intermediate-dose prophylactic anticoagulation, despite a higher incidence of VTE in the standard-dose group.

Mechanical and Metabolic Power in Accelerated Running-PART I: the 100-m dash.

PURPOSE: Acceleration phases require additional mechanical and metabolic power, over and above that for running at constant velocity. The present study is devoted to a paradigmatic example: the 100-m dash, in which case the forward acceleration is very high initially and decreases progressively to become negligible during the central and final phases. METHODS: The mechanical ([Formula: see text]) and metabolic ([Formula: see text]) power were analysed for both Bolt's extant world record and for medium level sprinters. RESULTS: In the case of Bolt, [Formula: see text] and [Formula: see text] attain peaks of ≈ 35 and ≈ 140 W kg-1 after ≈ 1 s, when the velocity is ≈ 5.5 m s-1; they decrease substantially thereafter, to attain constant values equal to those required for running at constant speed (≈ 18 and ≈ 65 W kg-1) after ≈ 6 s, when the velocity has reached its maximum (≈ 12 m s-1) and the acceleration is nil. At variance with [Formula: see text], the power required to move the limbs in respect to the centre of mass (internal power, [Formula: see text]) increases gradually to reach, after ≈ 6 s a constant value of ≈ 33 W kg-1. As a consequence, [Formula: see text] ([Formula: see text]) increases throughout the run to a constant value of ≈ 50 W kg-1. In the case of the medium level sprinters, the general patterns of speed, mechanical and metabolic power, neglecting the corresponding absolute values, follow an essentially equal trend. CONCLUSION: Hence, whereas in the last part of the run the velocity is about twice that observed after ≈ 1 s, [Formula: see text] and [Formula: see text] are reduced to 45-50% of the peak values.

Concurrent Validity and Reliability of the Sprint Force-Velocity Profile Assessed with K-AI Wearable Tech.

Establishing a sprint acceleration force-velocity profile is a way to assess an athlete's sprint-specific strength and speed production capacities. It can be determined in field condition using GNSS-based (global navigation satellite system) devices. The aims of this study were to (1) assess the inter-unit and the inter-trial reliability of the force-velocity profile variables obtained with K-AI Wearable Tech devices (50 Hz), (2) assess the concurrent validity of the input variables (maximal sprint speed and acceleration time constant), and (3) assess the validity of the output variables (maximal force output, running velocity and power). Twelve subjects, including one girl, performed forty-one 30 m sprints in total, during which the running speed was measured using two GPS (global positioning system) devices placed on the upper back and a radar (Stalker® Pro II Sports Radar Gun). Concurrent validity, inter-device and inter-trial reliability analyses were carried out for the input and output variables. Very strong to poor correlation (0.99 to 0.38) was observed for the different variables between the GPS and radar devices, with typical errors ranging from small to large (all < 7.6%). Inter-unit reliability was excellent to moderate depending on the variable (ICC values between 0.65 and 0.99). Finally, for the inter-trial reliability, the coefficients of variation were low to very low (all < 5.6%) for the radar and the GPS. The K-AI Wearable Tech used in this study is a concurrently valid and reliable alternative to radar for assessing a sprint acceleration force-velocity profile.

Annulated Azuleno[2,1,8-ija]azulenes: Synthesis and Properties.

Non-alternant non-benzenoid hydrocarbons exhibit very different optical and electronic properties than their well-studied benzenoid analogues. However, preparing such structures with extended conjugation length, remains challenging. Herein, we report the synthesis and properties of azuleno[2,1,8-ija]azulene derivatives using a two-step sequence involving a four-fold aldol condensation between aromatic dialdehydes and readily available tetrahydropentalene-2,5-(1H,3H)-dione. Molecules with band gap values ranging from 1.69 to 2.14 eV and molar extinction coefficients (ϵ) of nearly 3×105  M-1 cm-1 have been prepared. These annulene-like structures exhibit significant diatropic ring currents (aromatic), as supported by 1 H NMR spectroscopy and DFT calculations. Field-effect transistors (OFETs) using azuleno[2,1,8-ija]azulene derivatives as semiconductors exhibit charge mobility values of up to 0.05 cm2  V-1 s-1 .

Early steroids and ventilator-associated pneumonia in COVID-19-related ARDS.

RATIONALE: Early corticosteroid treatment is used to treat COVID-19-related acute respiratory distress syndrome (ARDS). Infection is a well-documented adverse effect of corticosteroid therapy. OBJECTIVES: To determine whether early corticosteroid therapy to treat COVID-19 ARDS was associated with ventilator-associated pneumonia (VAP). METHODS: We retrospectively included adults with COVID-19-ARDS requiring invasive mechanical ventilation (MV) for ≥ 48 h at any of 15 intensive care units in 2020. We divided the patients into two groups based on whether they did or did not receive corticosteroids within 24 h. The primary outcome was VAP incidence, with death and extubation as competing events. Secondary outcomes were day 90-mortality, MV duration, other organ dysfunctions, and VAP characteristics. MEASUREMENTS AND MAIN RESULTS: Of 670 patients (mean age, 65 years), 369 did and 301 did not receive early corticosteroids. The cumulative VAP incidence was higher with early corticosteroids (adjusted hazard ratio [aHR] 1.29; 95% confidence interval [95% CI] 1.05-1.58; P = 0.016). Antibiotic resistance of VAP bacteria was not different between the two groups (odds ratio 0.94, 95% CI 0.58-1.53; P = 0.81). 90-day mortality was 30.9% with and 24.3% without early corticosteroids, a nonsignificant difference after adjustment on age, SOFA score, and VAP occurrence (aHR 1.15; 95% CI 0.83-1.60; P = 0.411). VAP was associated with higher 90-day mortality (aHR 1.86; 95% CI 1.33-2.61; P = 0.0003). CONCLUSIONS: Early corticosteroid treatment was associated with VAP in patients with COVID-19-ARDS. Although VAP was associated with higher 90-day mortality, early corticosteroid treatment was not. Longitudinal randomized controlled trials of early corticosteroids in COVID-19-ARDS requiring MV are warranted.

Optimal mechanical force-velocity profile for sprint acceleration performance.

The aim was to determine the respective influences of sprinting maximal power output ( P H max ) and mechanical Force-velocity (F-v) profile (ie, ratio between horizontal force production capacities at low and high velocities) on sprint acceleration performance. A macroscopic biomechanical model using an inverse dynamics approach applied to the athlete's center of mass during running acceleration was developed to express the time to cover a given distance as a mathematical function of P H max and F-v profile. Simulations showed that sprint acceleration performance depends mainly on P H max , but also on the F-v profile, with the existence of an individual optimal F-v profile corresponding, for a given P H max , to the best balance between force production capacities at low and high velocities. This individual optimal profile depends on P H max and sprint distance: the lower the sprint distance, the more the optimal F-v profile is oriented to force capabilities and vice versa. When applying this model to the data of 231 athletes from very different sports, differences between optimal and actual F-v profile were observed and depend more on the variability in the optimal F-v profile between sprint distances than on the interindividual variability in F-v profiles. For a given sprint distance, acceleration performance (<30 m) mainly depends on P H max and slightly on the difference between optimal and actual F-v profile, the weight of each variable changing with sprint distance. Sprint acceleration performance is determined by both maximization of the horizontal power output capabilities and the optimization of the mechanical F-v profile of sprint propulsion.

Uphill sprinting load- and force-velocity profiling: Assessment and potential applications.

This study aimed to quantify the validity and reliability of load-velocity (LV) relationship of hill sprinting using a range of different hill gradients and to describe the effect of hill gradient on sprint performance. Twenty-four collegiate-level athletes performed a series of maximal sprints on either flat terrain or hills of gradients 5.2, 8.8 and 17.6%. Velocity-time curves were recorded using a radar device. LV relationships were established using the maximal velocity achieved in each sprinting condition, whilst force-velocity-power (FVP) profiles were established using only the flat terrain sprint. LV profiles were shown to be valid (R2 = 0.99) and reliable (TE < 4.4%). For every 1-degree increase in slope, subjects' velocity decreased by 1.7 ± 0.1% on average. All the slopes used represented low resistance relative to the entire LV spectrum (<25% velocity loss). Subjects who exhibited greater horizontal force output at higher velocities on flat terrain were most affected by the gradient of the hill. Hills of gradients up to 17.6% do not provide sufficient resistance to optimize power development. However, such hills could be used to develop late-stage technical ability, due to the prolonged horizontally oriented body position that occurs as subjects attempt to overcome the acceleration due to gravity.

Influence of prehospital management on the outcome of spinal cord decompression sickness in scuba divers.

BACKGROUND: Decompression sickness (DCS) with spinal cord involvement has an unfortunately high rate of long-term sequelae. The objective of this study was to determine the association of prehospital variables on the outcome of spinal cord DCS, especially the influence of the initial clinical presentation and the time to recompression. METHODS: This was a retrospective study using prospectively collected data which included divers with spinal cord DCS seen at a single hyperbaric centre study from 2010 to 2018. Information regarding dive, latency of onset of symptoms, time to recompression and prehospital management, that is, use of oxygen, treatment and means of evacuation, were analysed as predictor variables. The initial clinical severity was estimated by the score of the French society of diving and hyperbaric medicine (MEDSUBHYP). The primary end point was the presence or absence of sequelae at discharge assessed by the modified score of the Japanese Orthopedic Association. RESULTS: 195 divers (48±12 years, 42 women) were included. 34% had neurological sequelae at discharge. In multivariate analysis, a MEDSUBHYP score ≥6 and a time to recompression >194 min were significantly associated with incomplete neurological recovery (OR 9.5 (95% CI 4.6 to 19.8), p<0.0001 and OR 2.1 (95% CI 1.03 to 4.5), p=0.04, respectively). Time to recompression only appeared to be significant for patients with high initial clinical severity. As time to recompression increased, the level of sequelae also increased (p=0.014). CONCLUSION: Determining the initial clinical severity is critical in identifying patients who need to be evacuated for recompression as quickly as possible.

Sprint Acceleration Mechanical Outputs Derived from Position- or Velocity-Time Data: A Multi-System Comparison Study.

To directly compare five commonly used on-field systems (motorized linear encoder, laser, radar, global positioning system, and timing gates) during sprint acceleration to (i) measure velocity−time data, (ii) compute the main associated force−velocity variables, and (iii) assess their respective inter-trial reliability. Eighteen participants performed three 40 m sprints, during which five systems were used to simultaneously and separately record the body center of the mass horizontal position or velocity over time. Horizontal force−velocity mechanical outputs for the two best trials were computed following an inverse dynamic model and based on an exponential fitting of the position- or velocity-time data. Between the five systems, the maximal running velocity was close (7.99 to 8.04 m.s−1), while the time constant showed larger differences (1.18 to 1.29 s). Concurrent validity results overall showed a relative systematic error of 0.86 to 2.28% for maximum and theoretically maximal velocity variables and 4.78 to 12.9% for early acceleration variables. The inter-trial reliability showed low coefficients of variation (all <5.74%), and was very close between all of the systems. All of the systems tested here can be considered relevant to measure the maximal velocity and compute the force−velocity mechanical outputs. Practitioners are advised to interpret the data obtained with either of these systems in light of these results.

Effects of Repeated Sprint Training With Progressive Elastic Resistance on Sprint Performance and Anterior-Posterior Force Production in Elite Young Soccer Players.

ABSTRACT: Le Scouarnec, J, Samozino, P, Andrieu, B, Thubin, T, Morin, JB, and Favier, FB. Effects of repeated sprint training with progressive elastic resistance on sprint performance and anterior-posterior force production in elite young soccer players. J Strength Cond Res 36(6): 1675-1681, 2022-This study aimed to determine whether repeated sprint training with progressive high elastic resistance could improve sprint performance and anterior-posterior (AP) force production capacities of elite young soccer players. Seven elite U19 soccer players underwent 10 sessions of elastic-resisted repeated sprints on 8 weeks, whereas 8 U17 players from the same academy (control group) followed the same protocol without elastic bands. Sprint performance and mechanical parameters were recorded on a 30-m sprint before and after training. The control group did not show change for any of the measured variables. In contrast, the elastic-resisted training resulted in a significant improvement of the sprint time (-2.1 ± 1.3%; p = 0.026; Hedges' g = -0.49) and maximal velocity (Vmax; +3.9 ± 2%; p = 0.029; Hedges' g = 0.61) reached during the 30-m sprint. These enhancements were concurrent with an increase in the maximal power output related to AP force (Pmax; +4.9 ± 5.1%%; p = 0.026; Hedges' g = 0.42). Although the theoretical maximal AP force (F0) remained unchanged in both groups, there was a medium but nonsignificant increase in theoretical maximal velocity (V0; +3.7 ± 2.5%; p = 0.13; Hedges' g = 0.5) only in the elastic group. Therefore, the present results show that sprint capacity of elite young soccer players can be further improved by adding incremental resistance against runner displacement to raise the ability to produce AP force, rather at high velocity in the final phase of the acceleration.

Individual Adaptation Kinetics Following Heavy Resisted Sprint Training.

ABSTRACT: Morin, JB, Capelo-Ramirez, F, Rodriguez-Pérez, MA, Cross, MR, and Jimenez-Reyes, P. Individual adaptation kinetics following heavy resisted sprint training. J Strength Cond Res 36(4): 1158-1161, 2022-The aim of this study was to test individual adaptation kinetics to a high-resistance sprint training program designed to improve maximal horizontal power (Pmax), and compare the group and individual results of a classical "pre-post" analysis, and a "pre-peak" approach. Thirteen male and 9 female trained sprinters had their 30-m sprint performance and mechanical outputs assessed 1 week before (PRE), and one (POST, W1), 2 (W2), 3 (W3) and 4 (W4) weeks after a 10-week training block (10 repetitions of 20-m resisted sprints at the load associated to the apex of their velocity-power relationship: i.e., 90 ± 10% body mass on average (range: 75-112%). We observed clearly different outcomes on all variables for the PRE-POST vs. PRE-PEAK analyses. The PRE-PEAK analysis showed a larger (almost double) increase in Pmax (9.98 ± 5.27% on average, p < 0.01) than the PRE-POST (5.39 ± 5.87%, p < 0.01). Individual kinetics of post-training adaptations show that peak values were not captured in the POST (W1) assessment (generally observed at W3 and W4). Finally, the week of greatest Pmax output differed strongly among subjects, with most subjects (7/22) peaking at W4. In conclusion, after a 10-week high-resistance sprint training block, a classical 1-week-PRE to 1-week-POST assessment could not capture peak adaptation, which differed among athletes. Adopting a similar approach in practice or research should improve insight into the true effects of training stimuli on athletic capabilities.

Seasonal Changes in the Sprint Acceleration Force-Velocity Profile of Elite Male Soccer Players.

ABSTRACT: Jiménez-Reyes, P, Garcia-Ramos, A, Párraga-Montilla, JA, Morcillo-Losa, JA, Cuadrado-Peñafiel, V, Castaño-Zambudio, A, Samozino, P, and Morin, J-B. Seasonal changes in the sprint acceleration force-velocity profile of elite male soccer players. J Strength Cond Res 36(1): 70-74, 2022-This study aimed to describe the seasonal changes in the sprint force-velocity (Fv) profile of professional soccer players. The sprint Fv profile of 21 male soccer players competing in the first division of the Spanish soccer league was evaluated 6 times: preseason 1 (September 2015), in-season 1 (November 2015), in-season 2 (January 2016), in-season 3 (March 2016), in-season 4 (May 2016), and preseason 2 (August 2016). No specific sprint capabilities stimuli other than those induced by soccer training were applied. The following variables were calculated from the velocity-time data recorded with a radar device during an unloaded sprint: maximal force (F0), maximal velocity (v0), Fv slope, maximal power (Pmax), decrease in the ratio of horizontal-to-resultant force (DRF), and maximal ratio of horizontal-to-resultant force (RFpeak). F0 (effect size [ES] range = 0.83-0.93), Pmax (ES range = 0.97-1.05), and RFpeak (ES range = 0.56-1.13) were higher at the in-seasons 2 and 3 compared with both preseasons (p ≤ 0.006). No significant differences were observed for v0, Fv slope, and DRF (p ≥ 0.287). These results suggest that relevant Fv profile variables may be compromised (F0 more compromised than v0) toward the end of the competitive season when specific sprint stimuli are not systematically applied.

Short-term memory reactivation of a weak CS-US association promotes long-term memory persistence in conditioned odor aversion.

In conditioned odor aversion (COA), the association of a tasteless odorized solution (the conditioned stimulus [CS]) with an intraperitoneal injection of LiCl (the unconditioned stimulus [US[), which produces visceral malaise, results in its future avoidance. The strength of this associative memory is mainly dependent on two parameters, that is, the strength of the US and the interstimuli interval (ISI). In rats, COA has been observed only with ISIs of ≤15 min and LiCl (0.15 M) doses of 2.0% of bodyweight, when tested 48 h after acquisition (long-term memory [LTM]). However, we previously reported a robust aversion in rats trained with ISIs up to 60 min when tested 4 h after acquisition (short-term memory [STM]). Since memories get reactivated during retrieval, in the current study we hypothesized that testing for STM would reactivate this COA trace, strengthening its LTM. For this, we compared the LTM of rats trained with long ISIs or low doses of LiCl initially tested for STM with that of rats tested for LTM only. Interestingly, rats conditioned under parameters sufficient to produce STM, but not LTM, showed a reliable LTM when first tested for STM. These observations suggest that under suboptimal training conditions, such as long ISIs or low US intensities, a CS-US association is established but requires reactivation in the short-term in order to persist in the long-term.

A novel multifactorial hamstring screening protocol: association with hamstring muscle injuries in professional football (soccer) - a prospective cohort study.

The aim of this pilot study was to analyze the potential association of a novel multifactorial hamstring screening protocol with the occurrence of hamstring muscle injuries (HMI) in professional football. 161 professional male football players participated in this study (age: 24.6 ± 5.36 years; body-height: 180 ± 7.07 cm; body-mass: 77.2 ± 7.70 kg). During the pre- and mid-season, players performed a screening protocol consisting of 11 tests aimed to evaluate their performance in regards to four main musculoskeletal categories: posterior chain strength, sprint mechanical output, lumbopelvic control and range of motion. Univariable cox regression analysis showed no significant association between the isolated test results and new HMI occurrence during the season (n = 17) (p > 0.05). When including injuries that took place between the pre- and mid-season screenings (~90 days), maximal theoretical horizontal force (F0) was significantly associated with higher HMI risk between pre- and mid-season evaluations (n = 14, hazard ratio; 4.02 (CI95% 1.08 to 15.0, p = 0.04). This study identified that 1) no single screening test was sufficient to identify players at risk of HMI within the entire season, while 2) low F0 was associated with increased risk of HMI when occurring closer to the moment of screening. The present results support the potential relevance of additionally including frequent F0 testing for HMI risk reduction management. Replication studies are needed in larger cohorts for more accurate interpretations on "univariable and multivariable levels levels. Finally, future studies should explore whether improving F0 is relevant within a multifactorial HMI risk reduction approach.