Detalhe da pesquisa
1.
Radiosynthesis and preclinical PET evaluation of 89Zr-nivolumab (BMS-936558) in healthy non-human primates.
Bioorg Med Chem
; 25(20): 5407-5414, 2017 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28803798
2.
Novel phenylalanine derived diamides as Factor XIa inhibitors.
Bioorg Med Chem Lett
; 26(2): 472-478, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26704266
3.
Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics.
Expert Rev Proteomics
; 12(2): 159-69, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25711416
4.
Pyridine and pyridinone-based factor XIa inhibitors.
Bioorg Med Chem Lett
; 25(4): 925-30, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25592713
5.
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
Bioorg Med Chem Lett
; 25(7): 1635-42, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728130
6.
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.
Bioorg Med Chem Lett
; 21(1): 537-41, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078556
7.
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11ß-hydroxydehydrogenase 1 (11ß-HSD1).
Bioorg Med Chem Lett
; 21(22): 6693-8, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21983444
8.
Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg Med Chem Lett
; 18(11): 3168-72, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18485702
9.
Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties.
Bioorg Med Chem Lett
; 18(9): 2845-9, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18424044
10.
Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).
ACS Med Chem Lett
; 9(12): 1170-1174, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613321
11.
Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
J Med Chem
; 60(12): 4932-4948, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28537398
12.
Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening.
J Med Chem
; 58(6): 2799-808, 2015 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25764119
13.
The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor.
J Am Soc Mass Spectrom
; 25(12): 2093-102, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25223306
14.
Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).
ACS Med Chem Lett
; 5(7): 803-8, 2014 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25050169
15.
Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors.
J Med Chem
; 57(3): 955-69, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24405333
16.
Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity.
J Med Chem
; 57(23): 9915-32, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25405503
17.
Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem
; 57(5): 1855-79, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24397558
18.
SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa.
Bioorg Med Chem Lett
; 17(16): 4419-27, 2007 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17588746
19.
Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme.
Arch Biochem Biophys
; 410(2): 307-16, 2003 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12573291