1.
Chem Pharm Bull (Tokyo)
; 58(12): 1617-21, 2010 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21139265
RESUMO
The methanolic extract and its 1-butanol-soluble fraction from the flower buds of Camellia sasanqua THUNB. were found to show inhibitory activities on the release of ß-hexosaminidase from rat basophile leukemia (RBL-2H3) cells. From the 1-butanol-soluble fraction, five new acylated oleanane-type triterpene saponins, sasanquasaponins I-V, were isolated together with a known saponin and their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The principal saponin constituents, sasanquasaponins I-III, with an acyl group at the 22-position of the aglycon part showed the inhibitory effects on the release of ß-hexosaminidase and some structure-activity relationships were reported.