Photoinduced Dynamic Ligation in Metal-Organic Frameworks.

Metal organic frameworks (MOFs), a class of porous crystalline materials consisting of metal-based nodes and organic linkers, have emerged as a promising platform for photocatalysis due to their ultrahigh functional surface area, customizable topologies, and tunable energetics. While interesting photochemistry has been reported, the related photoinduced structural dynamics of MOFs remains unclear. The consensus is that the coordination bonds between MOF nodes and linkers are considered static during photoexcitation, while the open-metal sites on the nodes are taken as the key active sites for catalysis. In this work, through a complementary time-resolved visible and infrared (IR) spectroscopic investigation, along with computational studies, we report for the first time light-induced structural bond dissociation (COO-M) and reformation in an iron-oxo framework, MIL-101(Fe). The probed excited state displayed ligand-to-metal charge transfer (LMCT) characteristics and exhibited a ca. 30 µs lifetime. The incredibly long excited-state lifetime led us to probe potential structural rearrangements that facilitated charge separation in MIL-101(Fe). By probing the vibrational fingerprints of the carboxylate linker upon LMCT photoexcitation, we observed the reversible transition of the carboxylate-Fe bond from a bidentate bridging mode to a monodentate mode, indicating the partial dissociation of the carboxylate ligand. Importantly, the bidentate configuration is recovered on the same time scale of the excited state lifetimes as probed via visible transient absorption spectroscopy. The elucidated photoinduced configurational dynamics provides a foundation for an in-depth understanding of MOF-based photocatalytic mechanisms.

Rapid Exciton Transport and Structural Defects in Individual Porphyrinic Metal Organic Framework Microcrystals.

To date, spectroscopic characterization of porphyrin-based metal organic frameworks (MOFs) has relied almost exclusively on ensemble techniques, which provide only structurally averaged insight into the functional properties of these promising photochemical platforms. This work employs time-resolved pump-probe microscopy to probe ultrafast dynamics in PCN-222 MOF single crystals. The simultaneous high spatial and temporal resolution of the technique enables the correlation of spectroscopic observables to both inter- and intracrystal structural heterogeneity. The pump-probe measurements show that significant differences in the excited state lifetime exist between individual PCN-222 crystals of an ensemble. On a single PCN-222 crystal, differences in excited state lifetime and photoluminescence quantum yield are found to correlate to microscale structural defects introduced at crystallization. Pump probe microscopy also enables the direct measurement of excited state transport. Imaging of exciton transport on individual MOF crystals reveals rapid, but subdiffusive exciton transport which slows on the 10s of ps time scale. Time-averaged exciton diffusion coefficients over the first 200 ps span a range of 0.27 to 1.0 cm2/s, indicating that excited states are rapidly transported through the porphyrin network of PCN-222 before being trapped. Together, these single-particle-resolved measurements provide important new insight into the role played by structural defects on the photochemical functionality of porphyrin-based MOFs.

Supramolecular Metal Halide Complexes for High-Temperature Nonlinear Optical Switches.

Nonlinear optical (NLO) switching materials, which exhibit reversible intensity modulation in response to thermal stimuli, have found extensive applications across diverse fields including sensing, photoelectronics, and photonic applications. While significant progress has been made in solid-state NLO switching materials, these materials typically showcase their highest NLO performance near room temperature. However, this performance drastically deteriorates upon heating, primarily due to the phase transition undergone by the materials from noncentrosymmetric to centrosymmetric phase. Here, we introduce a new class of NLO switching materials, solid-state supramolecular compounds 18-Crown-6 ether@Cu2Cl4·4H2O (1·4H2O), exhibiting reversible and stable NLO switching when subjected to near-infrared (NIR) photoexcitation and/or thermal stimuli. The reversible crystal structure in response to external stimuli is attributed to the presence of a weakly coordinated bridging water molecule facilitated by hydrogen bonding/chelation interactions between the metal halide and crown-ether supramolecules. We observed an exceptionally high second-harmonic generation (SHG) signal under continuous photoexcitation, even at temperatures exceeding 110 °C. In addition, the bridging water molecules within the complex can be released and recaptured in a fully reversible manner, all without requiring excessive energy input. This feature allows for precise control of SHG signal activation and deactivation through structural transformations, resulting in a high-contrast off/on ratio, reaching values in the million-fold range.

Synergistic Steric and Electronic Effects on the Photoredox Catalysis by a Multivariate Library of Titania Metal-Organic Frameworks.

Metal-organic frameworks (MOFs) that display photoredox activity are attractive materials for sustainable photocatalysis. The ability to tune both their pore sizes and electronic structures based solely on the choice of the building blocks makes them amenable for systematic studies based on physical organic and reticular chemistry principles with high degrees of synthetic control. Here, we present a library of eleven isoreticular and multivariate (MTV) photoredox-active MOFs, UCFMOF-n, and UCFMTV-n-x% with a formula Ti6O9[links]3, where the links are linear oligo-p-arylene dicarboxylates with n number of p-arylene rings and x mol% of multivariate links containing electron-donating groups (EDGs). The average and local structures of UCFMOFs were elucidated from advanced powder X-ray diffraction (XRD) and total scattering tools, consisting of parallel arrangements of one-dimensional (1D) [Ti6O9(CO2)6]∞ nanowires connected through the oligo-arylene links with the topology of the edge-2-transitive rod-packed hex net. Preparation of an MTV library of UCFMOFs with varying link sizes and amine EDG functionalization enabled us to study both their steric (pore size) and electronic (highest occupied molecular orbital-lowest unoccupied molecular orbital, HOMO-LUMO, gap) effects on the substrate adsorption and photoredox transformation of benzyl alcohol. The observed relationship between the substrate uptake and reaction kinetics with the molecular traits of the links indicates that longer links, as well as increased EDG functionalization, exhibit impressive photocatalytic rates, outperforming MIL-125 by almost 20-fold. Our studies relating photocatalytic activity with pore size and electronic functionalization demonstrate how these are important parameters to consider when designing new MOF photocatalysts.

How Three Self-Secreted Biofilm Exopolysaccharides of Pseudomonas aeruginosa, Psl, Pel, and Alginate, Can Each Be Exploited for Antibiotic Adjuvant Effects in Cystic Fibrosis Lung Infection.

In cystic fibrosis (CF), pulmonary infection with Pseudomonas aeruginosa is a cause of increased morbidity and mortality, especially in patients for whom infection becomes chronic and there is reliance on long-term suppressive therapies. Current antimicrobials, though varied mechanistically and by mode of delivery, are inadequate not only due to their failure to eradicate infection but also because they do not halt the progression of lung function decline over time. One of the reasons for this failure is thought to be the biofilm mode of growth of P. aeruginosa, wherein self-secreted exopolysaccharides (EPSs) provide physical protection against antibiotics and an array of niches with resulting metabolic and phenotypic heterogeneity. The three biofilm-associated EPSs secreted by P. aeruginosa (alginate, Psl, and Pel) are each under investigation and are being exploited in ways that potentiate antibiotics. In this review, we describe the development and structure of P. aeruginosa biofilms before examining each EPS as a potential therapeutic target for combating pulmonary infection with P. aeruginosa in CF, with a particular focus on the current evidence for these emerging therapies and barriers to bringing these therapies into clinic.

Buckwheat (Fagopyrum esculentum) Hulls Are a Rich Source of Fermentable Dietary Fibre and Bioactive Phytochemicals.

Pseudo-cereals such as buckwheat (Fagopyrum esculentum) are valid candidates to promote diet biodiversity and nutrition security in an era of global climate change. Buckwheat hulls (BHs) are currently an unexplored source of dietary fibre and bioactive phytochemicals. This study assessed the effects of several bioprocessing treatments (using enzymes, yeast, and combinations of both) on BHs' nutrient and phytochemical content, their digestion and metabolism in vitro (using a gastrointestinal digestion model and mixed microbiota from human faeces). The metabolites were measured using targeted LC-MS/MS and GC analysis and 16S rRNA gene sequencing was used to detect the impact on microbiota composition. BHs are rich in insoluble fibre (31.09 ± 0.22% as non-starch polysaccharides), protocatechuic acid (390.71 ± 31.72 mg/kg), and syringaresinol (125.60 ± 6.76 mg/kg). The bioprocessing treatments significantly increased the extractability of gallic acid, vanillic acid, p-hydroxybenzoic acid, syringic acid, vanillin, syringaldehyde, p-coumaric acid, ferulic acid, caffeic acid, and syringaresinol in the alkaline-labile bound form, suggesting the bioaccessibility of these phytochemicals to the colon. Furthermore, one of the treatments, EC_2 treatment, increased significantly the in vitro upper gastrointestinal release of bioactive phytochemicals, especially for protocatechuic acid (p < 0.01). The BH fibre was fermentable, promoting the formation mainly of propionate and, to a lesser extent, butyrate formation. The EM_1 and EC_2 treatments effectively increased the content of insoluble fibre but had no effect on dietary fibre fermentation (p > 0.05). These findings promote the use of buckwheat hulls as a source of dietary fibre and phytochemicals to help meet dietary recommendations and needs.

A Potential Roadmap to Integrated Metal Organic Framework Artificial Photosynthetic Arrays.

Metal organic frameworks (MOFs), a class of coordination polymers, gained popularity in the late 1990s with the efforts of Omar Yaghi, Richard Robson, Susumu Kitagawa, and others. The intrinsic porosity of MOFs made them a clear platform for gas storage and separation. Indeed, these applications have dominated the vast literature in MOF synthesis, characterization, and applications. However, even in those early years, there were hints to more advanced applications in light-MOF interactions and catalysis. This perspective focuses on the combination of both light-MOF interactions and catalysis: MOF artificial photosynthetic assemblies. Light absorption, charge transport, H2O oxidation, and CO2 reduction have all been previously observed in MOFs; however, work toward a fully MOF-based approach to artificial photosynthesis remains out of reach. Discussed here are the current limitations with MOF-based approaches: diffusion through the framework, selectivity toward high value products, lack of integrated studies, and stability. These topics provide a roadmap for the future development of fully integrated MOF-based assemblies for artificial photosynthesis.

Aqueous-Phase Destruction of Nerve-Agent Simulants at Copper Single Atoms in UiO-66.

Metal-organic frameworks (MOFs) have shown great success in aqueous-phase hydrolysis of nerve agents, with some even showing promise in the gas phase. However, both aqueous-phase reactivity and gas-phase reactivity are hindered because of the binding of the hydrolyzed products to the MOF nodes in a stable, bridging configuration, which limits turnover. Single transition-metal atoms in MOFs have been a growing field of interest for catalytic applications, and single atoms have been proposed to prevent the unwanted bridged conformation and increase catalytic turnover. To date, there has been little experimental evidence to support the hypothesis. Herein, we report two copper single atom-modified UiO-66 MOFs for nerve-agent simulant degradation. Despite the capping of highly active Zr4+ nodes with fewer Lewis acidic Cun+ atoms, the reactivity of both CuMOFs approaches that of native UiO-66 under aqueous conditions. Computational studies reveal that the Cu coordination environment impairs product inhibition with respect to the native MOF.

An Aluminum-Based Metal-Organic Cage for Cesium Capture.

Metal-organic cages are a class of supramolecular structures that often require the careful selection of organic linkers and metal nodes. Of this class, few examples of metal-organic cages exist where the nodes are composed of main group metals. Herein, we have prepared an aluminum-based metal-organic cage, H8[Al8(pdc)8(OAc)8O4] (Al-pdc-AA), using inexpensive and commercially available materials. The cage formation was achieved via solvothermal self-assembly of solvated aluminum and pyridine-dicarboxylic linkers in the presence of a capping agent, acetic acid. The obtained supramolecular structure was characterized by single-crystal X-ray diffraction (SCXRD), thermogravimetric analysis, and NMR spectroscopy. Based on crystal structure and computational analyses, the cage has a 3.7 Å diameter electron-rich cavity suitable for the binding of cations such as cesium (ionic radius of 1.69 Å). The host-guest interactions were probed with 1H and 133Cs NMR spectroscopy in DMSO, where at low concentrations, Cs+ binds to Al-pdc-AA in a 1:1 ratio. The binding site was identified from the crystal structure of CsH7[Al8(pdc)8(OAc)8O4] (Cs+⊂Al-pdc-AA), and a binding affinity of ∼106-107 M-1 was determined from NMR titration experiments. The Al-pdc-AA showed improved selectivity for cesium binding over alkali metal cations (Cs+ > Rb+ > K+ ≫ Na+ ∼ Li+). Collectively, the study reports a novel aluminum cage that can serve as a promising host for efficient and selective cesium removal.

Reactive Balance Responses After Mild Traumatic Brain Injury: A Scoping Review.

OBJECTIVE: Balance testing after concussion or mild traumatic brain injury (mTBI) can be useful in determining acute and chronic neuromuscular deficits that are unapparent from symptom scores or cognitive testing alone. Current assessments of balance do not comprehensively evaluate all 3 classes of balance: maintaining a posture; voluntary movement; and reactive postural response. Despite the utility of reactive postural responses in predicting fall risk in other balance-impaired populations, the effect of mTBI on reactive postural responses remains unclear. This review sought to (1) examine the extent and range of available research on reactive postural responses in people post-mTBI and (2) determine whether reactive postural responses (balance recovery) are affected by mTBI. DESIGN: Scoping review. METHODS: Studies were identified using MEDLINE, EMBASE, CINAHL, Cochrane Library, Dissertations and Theses Global, PsycINFO, SportDiscus, and Web of Science. Inclusion criteria were injury classified as mTBI with no confounding central or peripheral nervous system dysfunction beyond those stemming from the mTBI, quantitative measure of reactive postural response, and a discrete, externally driven perturbation was used to test reactive postural response. RESULTS: A total of 4747 publications were identified, and a total of 3 studies (5 publications) were included in the review. CONCLUSION: The limited number of studies available on this topic highlights the lack of investigation on reactive postural responses after mTBI. This review provides a new direction for balance assessments after mTBI and recommends incorporating all 3 classes of postural control in future research.

Pre Versus Post Implementation of a Pharmacologic Antishivering Protocol During Targeted Temperature Management Following Cardiac Arrest.

BACKGROUND: Targeted temperature management (TTM) is endorsed by various guidelines to improve neurologic outcomes following cardiac arrest. Shivering, a consequence of hypothermia, can counteract the benefits of TTM. Despite its frequent occurrence, consensus guidelines provide minimal guidance on the management of shivering. The purpose of this study was to evaluate the impact of a pharmacologic antishivering protocol in patients undergoing TTM following cardiac arrest on the incidence of shivering. METHODS: A retrospective observational cohort study at a large academic medical center of adult patients who underwent TTM targeting 33 °C following out-of-hospital (OHCA) or in-hospital cardiac arrest (IHCA) was conducted between January 2013 and January 2019. Patients were included in the preprotocol group if they received TTM prior to the initiation of a pharmacologic antishivering protocol in 2015. The primary outcome was incidence of shivering between pre- and postprotocol patients. Secondary outcomes included time from arrest (IHCA) or admission to the hospital (OHCA) to goal body temperature, total time spent at goal body temperature, and percentage of patients alive at discharge. All pharmacologic agents listed as part of the antishivering protocol were recorded. RESULTS: Fifty-one patients were included in the preprotocol group, and 80 patients were included in the postprotocol group. There were no significant differences in baseline characteristics between the groups, including percentage of patients experiencing OHCA (75% vs. 63%, p = 0.15) and time from arrest to return of spontaneous circulation (17.5 vs. 17.9 min, p = 0.96). Incidence of patients with shivering was significantly reduced in the postprotocol group (57% vs. 39%, p = 0.03). Time from arrest (IHCA) or admission to the hospital (OHCA) to goal body temperature was similar in both groups (5.1 vs. 5.3 h, p = 0.57), in addition to total time spent at goal body temperature (17.7 vs. 18 h, p = 0.93). The percentage of patients alive at discharge was significantly improved in the postprotocol group (35% vs. 55%, p = 0.02). Patients in the postprotocol group received significantly more buspirone (4% vs. 73%, p < 0.01), meperidine (8% vs. 34%, p < 0.01), and acetaminophen (12% vs. 65%, p < 0.01) as part of the pharmacologic antishivering protocol. Use of neuromuscular blockade significantly decreased post protocol (19% vs. 6%, p = 0.02). CONCLUSIONS: In patients undergoing TTM following cardiac arrest, the implementation of a pharmacologic antishivering protocol reduced the incidence of shivering and the use neuromuscular blocking agents. Prospective data are needed to validate the results and further evaluate the safety and efficacy of an antishivering protocol on clinical outcomes.

Dismantling systems of racism and oppression during adolescence: An agenda for anti-racist research.

In reflecting on the collection of work in the recent Journal of Research on Adolescence special series and what it means for research to dismantle systems of racism and oppression, we call for adolescent development researchers to embrace anti-racist research. We describe a set of strategies for conceptualizing, conducting, and disseminating research with adolescents using an anti-racist lens. These strategies flow from tenets of anti-racist research that include recognizing racism as systemic and being critically self-reflective on power and privilege, committed to doing no harm to adolescents, action-oriented, and community-centered. Despite obstacles to anti-racist research in academic and public ecosystems, anti-racist research is essential if we are interested in equity in adolescent' development and the well-being of all adolescents.

Nanoconfinement and mass transport in metal-organic frameworks.

The ubiquity of metal-organic frameworks in recent scientific literature underscores their highly versatile nature. MOFs have been developed for use in a wide array of applications, including: sensors, catalysis, separations, drug delivery, and electrochemical processes. Often overlooked in the discussion of MOF-based materials is the mass transport of guest molecules within the pores and channels. Given the wide distribution of pore sizes, linker functionalization, and crystal sizes, molecular diffusion within MOFs can be highly dependent on the MOF-guest system. In this review, we discuss the major factors that govern the mass transport of molecules through MOFs at both the intracrystalline and intercrystalline scale; provide an overview of the experimental and computational methods used to measure guest diffusivity within MOFs; and highlight the relevance of mass transfer in the applications of MOFs in electrochemical systems, separations, and heterogeneous catalysis.

Interadministrator Reliability of a Modified Instrumented Push and Release Test of Reactive Balance.

CONTEXT: Traditional assessments of reactive balance require sophisticated instrumentation to ensure objective, highly repeatable paradigms. This instrumentation is clinically impractical. The Push and Release test (P&R) is a well-validated clinical test that examines reactive balance, and the application of wearable inertial measurement units (IMU) enables sensitive and objective assessment of this clinically feasible test. The P&R relies on administrator experience and may be susceptible to interadministration reliability concerns. The purpose of this study was to evaluate the interadministrator reliability of objective outcomes from an instrumented, modified version of the P&R test. DESIGN: Crossover interadministrator design. METHODS: Twenty healthy adults (20-35 y) completed the P&R in 4 directions with 2 different administrators. Measures quantified using IMUs included step latency, step length, and time to stability. Lean angle (LA) at release was used as a measure of administration consistency. The intraclass correlation coefficient (ICC) estimate was used to assess interadministrator reliability in each direction. To determine consistency of LA within and across administrators, we calculated the SDs for each rater by direction and the interadministrator reliability of LA using ICC. RESULTS: Across individual directions, the ICC for agreement between raters ranged from .16 to .39 for step latency, from .52 to .62 for time to stability, and from .48 to .84 for step length. Summary metrics across all 4 directions produced higher ICC values. There was poor to moderate consistency in administration based on LA, but LA did not significantly affect any of the outcomes. CONCLUSION: The modified P&R yields moderate interadministrator reliability and high validity. Summary metrics over all 4 directions (the maximum step latency, the median time to stability, and the median step length) are likely more reliable than direction-specific scores. Variations in body size should also be considered when comparing populations.

Photoelectrochemical alcohol oxidation by mixed-linker metal-organic frameworks.

Metal-organic frameworks (MOFs) provide a suitable platform for stable and efficient heterogeneous photoelectrochemical oxidation catalysis due to their highly ordered structure, large surface area, and synthetic tunability. Herein, a mixed-linker MOF comprising of a photosensitizer [Ru(dcbpy)(bpy)2]2+ (bpy = 2,2'-bipyridine, dcbpy = 5,5'-dicarboxy-2,2'-bipyridine) and catalyst [Ru(tpy)(dcbpy)Cl]+ (tpy = 2,2':6',2''-terpyridine) that were incorporated into the UiO-67 framework and grown as thin films on a TiO2-coated, fluorine-doped tin oxide (FTO) electrode (RuB-RuTB-UiO-67/TiO2/FTO). When used as an electrode for the photoelectrochemical oxidation of benzyl alcohol, the mixed-linker MOF film showed a faradaic efficiency of 34%, corresponding to a 3-fold increase in efficiency relative to the RuB-UiO-67/TiO2/FTO control. This increase in catalytic efficiency is ascribed to the activation of RuTB moieties via oxidation by photogenerated RuIIIB. Transient absorption spectroscopy revealed the delayed appearance of RuIIITB* or RuIIITB formation, occurring with a lifetime of 21 ns, due to energy and/or electron transfer. The recovery kinetics of the charge separated state was increased (283 µs) in comparison to single-component control experiments (105 µs for RuB-UiO-67/TiO2/FTO and 7 µs for RuTB-UiO-67/TiO2/FTO) indicating a cooperative effect that could be exploited in chromophore/catalyst MOF motifs.

Defect Level and Particle Size Effects on the Hydrolysis of a Chemical Warfare Agent Simulant by UiO-66.

Defect engineering in metal-organic frameworks (MOFs) has recently become an area of significant research due to the possibility of enhancing material properties such as internal surface area and catalytic activity while maintaining stable 3D structures. Through a modulator screening study, the model Zr4+ MOF, UiO-66, has been synthesized with control of particle sizes (100-1900 nm) and defect levels (2-24%). By relating these properties, two series were identified where one property remained constant, allowing for independent analysis of the defect level or particle size, which frequently change coincident with the modulator choice. The series were used to compare UiO-66 reactivity for the hydrolysis of a chemical warfare agent simulant, dimethyl 4-nitrophenylphosphate (DMNP). The rate of DMNP hydrolysis displayed high dependence on the external surface area, supporting a reaction dominated by surface interactions. Moderate to high concentrations of defects (14-24%) allow for the accessibility of some interior MOF nodes but do not substantially promote diffusion into the framework. Individual control of defect levels and particle sizes through modulator selection may provide useful materials for small molecular catalysis and provide a roadmap for similar engineering of other zirconium frameworks.

Mechanistic Investigations into and Control of Anisotropic Metal-Organic Framework Growth.

The porphyrinic metal-organic framework, PCN-222, exhibits anisotropic growth behavior to form nanorods and microrods with aspect ratios 3 < x < 94. Control of microrod aspect ratios has been demonstrated through the identification of several factors that dictate crystal growth, particularly the concentrations of a ligand, a modulator, and an exogenous base. An increase in the local concentration of a deprotonated ligand, which is proportional to the nucleation rate, is associated with smaller crystals, while increased modulator concentration leads to longer microrods. Addition of a deprotonating agent not only contributes to higher aspect ratios but also results in an improvement to particle dispersity. Here, we report acid-base co-modulation methods with difluoroacetic acid and triethylamine to effectively tune PCN-222 aspect ratios. A series of mechanisms is identified for the growth of PCN-222: (1) ligand deprotonation, (2) nucleation, (3) oriented attachment, (4) Ostwald ripening, and (5) dissolution-recrystallization. Time trials of co-modulated samples revealed three separate ripening growth events, with each resulting in larger and more monodisperse crystals. With an understanding of these crystal growth factors and mechanisms, the highest aspect ratio, non-templated metal-organic frameworks were synthesized (94 ± 9).

Gastric symptoms and low perceived maternal warmth are associated with eating disorder symptoms in young adolescent girls.

OBJECTIVE: This study sought to determine whether gastric symptoms are associated with later eating disorder (ED) symptoms during early adolescence, and whether this relationship is moderated by parental warmth/acceptance and/or the child's sex. METHOD: Longitudinal data from the Adolescent Brain Cognitive DevelopmentSM Study were utilized. Participants ages 9-10 years old (N = 4,950; 2,370 female) completed measures at baseline and 1 year later (Y1). At baseline, gastric symptoms were measured by parent-reported items from the Child Behavior Checklist (CBCL), and perceived parental acceptance was measured by youth report on the Children's Report of Parent Behavior Inventory (CRPBI) Acceptance subscale separately for mothers and fathers. ED symptoms at Y1 were assessed by parent report on a computerized version of the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS). Linear mixed-effects models were conducted separately for maternal and paternal acceptance to test relationships among variables. RESULTS: A three-way interaction between baseline gastric symptoms, sex, and maternal acceptance predicted Y1 ED symptoms (𝛽 = 0.08; p < .01). Post-hoc analyses revealed that the interaction between gastric symptoms and maternal acceptance was significant for girls only (𝛽 = -0.06, p < .01), such that low maternal acceptance was associated with a stronger relationship between baseline gastric symptoms and Y1 ED symptoms. No statistically significant main effects or interactions were found in the model for paternal acceptance. DISCUSSION: Gastric symptoms and low perceived maternal acceptance may interact to result in heightened risk for EDs in young adolescent girls.

Extracurricular Activities, Screen Media Activity, and Sleep May Be Modifiable Factors Related to Children's Cognitive Functioning: Evidence From the ABCD Study®.

This study used a machine learning framework in conjunction with a large battery of measures from 9,718 school-age children (ages 9-11) from the Adolescent Brain Cognitive DevelopmentSM (ABCD) Study to identify factors associated with fluid cognitive functioning (FCF), or the capacity to learn, solve problems, and adapt to novel situations. The identified algorithm explained 14.74% of the variance in FCF, replicating previously reported socioeconomic and mental health contributors to FCF, and adding novel and potentially modifiable contributors, including extracurricular involvement, screen media activity, and sleep duration. Pragmatic interventions targeting these contributors may enhance cognitive performance and protect against their negative impact on FCF in children.

Into the Unknown: Examining Neural Representations of Parent-Adolescent Interactions.

The parent-adolescent relationship is important for adolescents' emotion regulation (ER), yet little is known regarding the neural patterns of dyadic ER that occur during parent-adolescent interactions. A novel measure that can be used to examine such patterns is cross-brain connectivity (CBC)-concurrent and time-lagged connectivity between two individuals' brain regions. This study sought to provide evidence of CBC and explore associations between CBC, parenting, and adolescent internalizing symptoms. Thirty-five adolescents (mean age = 15 years, 69% female, 72% Non-Hispanic White, 17% Black, 11% Hispanic or Latino) and one biological parent (94% female) completed an fMRI hyperscanning conflict discussion task. Results revealed CBC between emotion-related brain regions. Exploratory analyses indicated CBC is associated with parenting and adolescent depressive symptoms.